Results 221 to 230 of about 118,802 (309)

A narrative review of motor control dual pathways: the corticospinal and reticulospinal tracts in synergy and differentiation. [PDF]

Front Neuroanat
Xing Y, Liu J, Wu L, Zhang K, Yang S.
europepmc   +1 more source

The Role of Meprins on the Brain Extracellular Matrix and Perineuronal Nets

The FASEB Journal, Volume 40, Issue 13, 15 July 2026.
Meprin β overexpression is implicated in Alzheimer's Disease. Recent studies identified brevican as a meprin β substrate, and this study demonstrates that meprin α co‐expression enhances meprin β‐mediated brevican cleavage. Further, neurocan and RPTPζ were identified as novel meprin β substrates in an N‐terminomics analysis of meprin β transgenic mice,
Simon Kreiselmaier, Maximilian Keller, Leonardo Nardi, Constantin Mueller, Nele von Wiegen, Kira Bickenbach, Lea Gröbner, Mohammad Abukhalaf, Andreas Tholey, Margareta M. Mueller, Hagen Körschgen, Michael J. Schmeisser, Christoph Becker‐Pauly, Claus U. Pietrzik   +13 more
wiley   +1 more source

Group I metabotropic glutamate receptors differentially modulate excitatory transmission across interneuron types in the human cortex. [PDF]

Front Synaptic Neurosci
Sandle JG, Molnár G, Tóth M, Kocsis KÁ, Csajbók ÉA, Barzó P, Lamsa K, Tamás G.   +7 more
europepmc   +1 more source

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, Volume 13, Issue 38, 9 July 2026.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

Advanced Science, Volume 13, Issue 37, 3 July 2026.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu, Zifei Chen, Bingmei Sun, Jiale Gao, Jiale Xu, Xiaochun Guo, Fenfei Gao, Zhongsi Wang, Jie Wu, Xiaoyu Ji, Peipei Liu, Bing Huang   +11 more
wiley   +1 more source

Spinal and supraspinal mechanisms of chronic itch: from neuronal circuits to the neuro-immune-microbial axis. [PDF]

Front Med (Lausanne)
Gao S, Liu M, Qi Z, Li Y, Xue Y, Gao C.
europepmc   +1 more source

Noninvasive Focal Gene Delivery into the Cerebellum of Non‐Human Primates using Focused Ultrasound

Advanced Science, Volume 13, Issue 37, 3 July 2026.
Focal and non‐invasive viral vector delivery in non‐human primates remains a major challenge in translational neuroscience. Low‐intensity focused ultrasound was used to transiently open the blood–brain barrier and enable targeted gene delivery to the cerebellum.
Noelia Esteban‐García, José A. Pineda‐Pardo, Inés Trigo‐Damas, Marta Gutiérrez, Marta Castillo‐Ortiz, Megan Carrillo, Alejandro Reinares‐Sebastian, Víctor Medina‐Chavarrías, Itay Rachmilevitch, Masahiko Takada, José A. Obeso, Javier Blesa   +11 more
wiley   +1 more source

The dysconnection hypothesis of schizophrenia: a 30-year update. [PDF]

World Psychiatry
Friston K.
europepmc   +1 more source

Pharmacokinetics and pharmacodynamics of intravenous and oral (S)‐ketamine: Investigating metabolite contribution to subjective effects

British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2260-2271, July 2026.
Aims Oral administration of (S)‐ketamine for treatment‐resistant depression (TRD), as alternative to the registered intranasal or off‐label intravenous administrations, has high potential. However, it is characterized by an extensive first‐pass metabolism, resulting in low (S)‐ketamine exposure and high levels of active metabolites, including (S ...
Marije E. Otto, Gabriël E. Jacobs, Joost C. van Mechelen, Laura G. J. M. Borghans, Johan G. C. van Hasselt, Linda B. S. Aulin   +5 more
wiley   +1 more source