Results 21 to 30 of about 297,533 (307)

The stress polarity signaling (SPS) pathway serves as a marker and a target in the leaky gut barrier: implications in aging and cancer. [PDF]

, 2020
The gut barrier separates trillions of microbes from the largest immune system in the body; when compromised, a "leaky" gut barrier fuels systemic inflammation, which hastens the progression of chronic diseases.
Das, Soumita, Foretz, Marc, Ghosh, Pradipta, Ibeawuchi, Stella-Rita, Lim, Blaze B, Mittal, Yash, Sahoo, Debashis, Sayed, Ibrahim M, Swanson, Lee, Viollet, Benoit   +9 more
core   +3 more sources

Deciphering the complex signalling systems that regulate intestinal epithelial cell death processes and shedding [PDF]

, 2017
Intestinal epithelial cells play a fundamental role in maintaining homeostasis. Shedding of intestinal cells in a controlled manner is critical to maintenance of barrier function.
Agace, Albert, Anon, Arnold, Assi, Barker, Begnaud, Boehm, Brand, Brugués, Capaldo, Chen, Cheung, Du, Dunn, Dürer, Edelblum, Eisenhoffer, Elmore, Ericsson, Farooqui, George, Gilbert, Gu, Guan, Gudipaty, Günther, Günther, Günther, Heller, Hodge, Hughes, Kaemmerer, Kiesslich, Kim, Kocgozlu, Koch, Kofoed, Kuipers, Kumar, Le, Lhocine, Lindemans, Marchiando, Melendez, Nava, Niculescu, Parker, Patnaik, Pentecost, Pentecost, Peterson, Pruteanu, Rankin, Rauch, Ravasio, Sagulenko, Sellin, Smith, Solaymani-Mohammadi, Taylor, Ubelmann, Van Itallie, VanDussen, Wang, Wang, Wang, Watson, Williams, Wong   +69 more
core   +7 more sources

Intestinal permeability measurements: general aspects and possible pitfalls

Nutrición Hospitalaria, 2014
Introduction: Disturbances of the gut barrier function have been related to a variety of diseases, including intestinal and extra-intestinal diseases. The intestinal permeability tests are considered useful tools for evaluating disease severity and to ...
Tatiana Fiche Salles Teixeira, Ana Paula Boroni Moreira, Nilian Carla Silva Souza, Rafael Frias, Maria do Carmo Gouveia Peluzio   +4 more
doaj   +1 more source

Celiac Disease Monocytes Induce a Barrier Defect in Intestinal Epithelial Cells [PDF]

, 2019
Intestinal epithelial barrier function in celiac disease (CeD) patients is altered. However, the mechanism underlying this effect is not fully understood.
Branchi, Federica, Cardoso-Silva, Danielle, Delbue, Deborah, Itzlinger, Alice, Letizia, Marilena, Schumann, Michael, Siegmund, Britta   +6 more
core   +1 more source

Intestinal Barrier Function in Chronic Kidney Disease [PDF]

Toxins, 2018
The kidneys are key contributors to body homeostasis, by virtue of controlled excretion of excessive fluid, electrolytes, and toxic waste products. The syndrome of uremia equals the altered physiology due to irreversible loss of kidney function that is left uncorrected for, despite therapeutic intervention(s).
Meijers, Bjorn, Farre, Ricard, Dejongh, Sander, Vicario, Maria, Evenepoel, Pieter   +4 more
openaire   +3 more sources

Propionic Acid Targets the TLR4/NF-κB Signaling Pathway and Inhibits LPS-Induced Intestinal Barrier Dysfunction: In Vitro and In Vivo Studies

Frontiers in Pharmacology, 2020
Intestinal barrier dysfunction contributes to the development of intestinal diseases. Propionic acid (PA), a metabolite generated by anaerobic fermentation of dietary fiber in the intestinal cavity, has been proved to exert anti-inflammatory effects in a
Randong Yang, Xiaoxiao Hu, Xianzheng Xie, Haiqiong Chen, Huangyi Fang, Libing Zhu, Zhongrong Li   +6 more
doaj   +1 more source

Biomarkers for monitoring intestinal health in poultry : present status and future perspectives [PDF]

, 2018
Intestinal health is determined by host (immunity, mucosal barrier), nutritional, microbial and environmental factors. Deficiencies in intestinal health are associated with shifts in the composition of the intestinal microbiome (dysbiosis), leakage of ...
Antonissen, Gunther, De Meyer, Fien, Ducatelle, Richard, Eeckhaut, Venessa, Goossens, Evy, Haesebrouck, Freddy, Van Immerseel, Filip   +6 more
core   +3 more sources

Gut microbiota-derived tryptophan metabolite indole-3-carboxaldehyde enhances intestinal barrier function via aryl hydrocarbon receptor/AMP-activated protein kinase signaling activation [PDF]

Animal Bioscience
Objective Intestinal inflammatory diseases significantly affect animal health, primarily by disrupting intestinal barrier function. Indole-3-carboxaldehyde (IAld), a key metabolite of tryptophan derived from gut microbiota, exhibits protective properties
Donglin Shi, Yong Cui, Haiping Liang, Qing Wei, Jianzhen Huang, Ji Cao   +5 more
doaj   +1 more source

Intestinal barrier function and metabolic/liver diseases

Liver Research, 2020
Dietary, environmental or genetic changes contribute to the development of several metabolic and neurological diseases. Extensive research efforts have been directed towards examining how these factors modulate gut bacterial composition.
Siddhartha S. Ghosh, Jing Wang, Paul J. Yannie, Shobha Ghosh   +3 more
doaj   +1 more source

Mechanisms and Functional Implications of Intestinal Barrier Defects [PDF]

Digestive Diseases, 2009
Intestinal epithelial barrier defects, or increased paracellular permeability, were first reported in patients with Crohn’s disease (CD) over 25 years ago. Although increased permeability may herald relapse to active disease, suggesting that impaired barrier function may contribute to progression, limited understanding of the mechanisms that create ...
Le, Shen, Liping, Su, Jerrold R, Turner
openaire   +2 more sources