Results 1 to 10 of about 334,616 (250)

Intracellular cholesterol transport

Journal of Lipid Research, 1997
Recent data on the roles of vesicle- and ‘raft‘-mediated pathways in intracellular free cholesterol (FC) transport are reviewed. Cholesterol internalized from plasma lipoproteins is transferred via endocytic vesicles to the trans-Golgi network (TGN ...
C J Fielding, P E Fielding
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Intracellular Cholesterol Synthesis and Transport

Frontiers in Cell and Developmental Biology, 2022
Cholesterol homeostasis is related to multiple diseases in humans, including cardiovascular disease, cancer, and neurodegenerative and hepatic diseases.
Qingyang Shi, Jiahuan Chen, Xiaodong Zou, Xiaochun Tang, Xiaochun Tang   +4 more
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Intracellular cholesterol transport.

Journal of Lipid Research, 1992
The intracellular movement of cholesterol in mammalian cells may involve complex pathways by which the sterol moves to various cellular sites and mediates transcriptional regulation, enzyme activation, and protein degradation.
L Liscum, NK Dahl
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Mouse Syngeneic Melanoma Model with Human Epidermal Growth Factor Receptor Expression

Pharmaceutics, 2022
The development of epidermal growth factor receptor (EGFR)-targeting agents for the treatment of malignant melanoma requires cheap and easy animal tumor models for high-throughput in vivo screening.
Tatiana A. Slastnikova, Andrey A. Rosenkranz, Alexey V. Ulasov, Yuri V. Khramtsov, Tatiana N. Lupanova, Georgii P. Georgiev, Alexander S. Sobolev   +6 more
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Monovalent ions and stress-induced senescence in human mesenchymal endometrial stem/stromal cells

Scientific Reports, 2022
Monovalent ions are involved in growth, proliferation, differentiation of cells as well as in their death. This work concerns the ion homeostasis during senescence induction in human mesenchymal endometrium stem/stromal cells (hMESCs): hMESCs subjected ...
Alla Shatrova, Elena Burova, Natalja Pugovkina, Alisa Domnina, Nikolaj Nikolsky, Irina Marakhova   +5 more
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Modular Nanotransporters Delivering Biologically Active Molecules to the Surface of Mitochondria

Pharmaceutics, 2023
Treatment of various diseases, in particular cancer, usually requires the targeting of biologically active molecules at a selected subcellular compartment.
Yuri V. Khramtsov, Alexey V. Ulasov, Tatiana A. Slastnikova, Andrey A. Rosenkranz, Tatiana N. Lupanova, Georgii P. Georgiev, Alexander S. Sobolev   +6 more
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Intracellular Cholesterol Transport [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2004
Intracellular cholesterol transport is essential for the maintenance of cholesterol homeostasis. Many aspects of cholesterol metabolism are well-known, including its synthesis in the endoplasmic reticulum, its extracellular transport in plasma lipoproteins, its uptake by the low-density lipoprotein receptor, and its regulation of SREBP and LXR ...
Raymond E, Soccio, Jan L, Breslow
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Resistance to H2O2-induced oxidative stress in human cells of different phenotypes

Redox Biology, 2022
Application of genetically encoded biosensors of redox-active compounds promotes the elaboration of new methods for investigation of intracellular redox activities.
Valeriy Zenin, Julia Ivanova, Natalia Pugovkina, Alla Shatrova, Nikolay Aksenov, Irina Tyuryaeva, Kseniya Kirpichnikova, Ivan Kuneev, Andrei Zhuravlev, Ekaterina Osyaeva, Ekaterina Lyublinskaya, Ilyuza Gazizova, Nikita Guriev, Olga Lyublinskaya   +13 more
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Intracellular Degradation of SARS-CoV-2 N-Protein Caused by Modular Nanotransporters Containing Anti-N-Protein Monobody and a Sequence That Recruits the Keap1 E3 Ligase

Pharmaceutics, 2023
The proper viral assembly relies on both nucleic acids and structural viral proteins. Thus a biologically active agent that provides the degradation of one of these key proteins and/or destroys the viral factory could suppress viral replication ...
Yuri V. Khramtsov, Alexey V. Ulasov, Tatiana N. Lupanova, Tatiana A. Slastnikova, Andrey A. Rosenkranz, Egor S. Bunin, Georgii P. Georgiev, Alexander S. Sobolev   +7 more
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An Approach to Evaluate the Effective Cytoplasmic Concentration of Bioactive Agents Interacting with a Selected Intracellular Target Protein

Pharmaceutics, 2023
To compare the effectiveness of various bioactive agents reversibly acting within a cell on a target intracellular macromolecule, it is necessary to assess effective cytoplasmic concentrations of the delivered bioactive agents.
Yuri V. Khramtsov, Alexey V. Ulasov, Andrey A. Rosenkranz, Tatiana A. Slastnikova, Tatiana N. Lupanova, Georgii P. Georgiev, Alexander S. Sobolev   +6 more
doaj   +1 more source