Results 11 to 20 of about 803,683 (201)

Intracellular Cholesterol Transport [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2004
Intracellular cholesterol transport is essential for the maintenance of cholesterol homeostasis. Many aspects of cholesterol metabolism are well-known, including its synthesis in the endoplasmic reticulum, its extracellular transport in plasma lipoproteins, its uptake by the low-density lipoprotein receptor, and its regulation of SREBP and LXR ...
Raymond E, Soccio, Jan L, Breslow
openaire   +2 more sources

Intracellular Degradation of SARS-CoV-2 N-Protein Caused by Modular Nanotransporters Containing Anti-N-Protein Monobody and a Sequence That Recruits the Keap1 E3 Ligase

Pharmaceutics, 2023
The proper viral assembly relies on both nucleic acids and structural viral proteins. Thus a biologically active agent that provides the degradation of one of these key proteins and/or destroys the viral factory could suppress viral replication ...
Yuri V. Khramtsov, Alexey V. Ulasov, Tatiana N. Lupanova, Tatiana A. Slastnikova, Andrey A. Rosenkranz, Egor S. Bunin, Georgii P. Georgiev, Alexander S. Sobolev   +7 more
doaj   +1 more source

Resistance to H2O2-induced oxidative stress in human cells of different phenotypes

Redox Biology, 2022
Application of genetically encoded biosensors of redox-active compounds promotes the elaboration of new methods for investigation of intracellular redox activities.
Valeriy Zenin, Julia Ivanova, Natalia Pugovkina, Alla Shatrova, Nikolay Aksenov, Irina Tyuryaeva, Kseniya Kirpichnikova, Ivan Kuneev, Andrei Zhuravlev, Ekaterina Osyaeva, Ekaterina Lyublinskaya, Ilyuza Gazizova, Nikita Guriev, Olga Lyublinskaya   +13 more
doaj   +1 more source

An Approach to Evaluate the Effective Cytoplasmic Concentration of Bioactive Agents Interacting with a Selected Intracellular Target Protein

Pharmaceutics, 2023
To compare the effectiveness of various bioactive agents reversibly acting within a cell on a target intracellular macromolecule, it is necessary to assess effective cytoplasmic concentrations of the delivered bioactive agents.
Yuri V. Khramtsov, Alexey V. Ulasov, Andrey A. Rosenkranz, Tatiana A. Slastnikova, Tatiana N. Lupanova, Georgii P. Georgiev, Alexander S. Sobolev   +6 more
doaj   +1 more source

Managing intracellular transport [PDF]

Worm, 2013
Formation and normal function of neuronal synapses are intimately dependent on the delivery to and removal of biological materials from synapses by the intracellular transport machinery. Indeed, defects in intracellular transport contribute to the development and aggravation of neurodegenerative disorders.
Chua, J., Jahn, R., Klopfenstein, D.
openaire   +3 more sources

Intracellular cholesterol transport [PDF]

Journal of Clinical Investigation, 2002
Cholesterol is the single most abundant lipid species in mammalian cells. More than 2×109 years of evolution designed this molecule to perfectly fit into phospholipid bilayers regulating the fluidity, permeability and bending stiffness of biological membranes.
Frederick R, Maxfield, Daniel, Wüstner
openaire   +2 more sources

Intracellular transports and atherogenesis [PDF]

Frontiers in Bioscience, 2020
There is a great progress in understanding the cellular and molecular aspects of atherosclerosis, which is one of the leading causes of death. Yet, there are questions regarding the cellular and metabolic mechanisms that lead to atherogenesis. Among the many factors that influence this process, food plays a significant role.
Alexander A. Mirоnоv, Irina S. Sesorova, Ivan D. Dimov, Natalia R. Karelina, Galina V. Beznoussenko   +4 more
openaire   +3 more sources

Branched Actin Maintains Acetylated Microtubule Network in the Early Secretory Pathway

Cells, 2021
In the early secretory pathway, the delivery of anterograde cargoes from the endoplasmic reticulum (ER) exit sites (ERES) to the Golgi apparatus is a multi-step transport process occurring via the ER-Golgi intermediate compartment (IC, also called ERGIC).
Azumi Yoshimura, Stéphanie Miserey-Lenkei, Evelyne Coudrier, Bruno Goud   +3 more
doaj   +1 more source

Targeted Delivery of 111In Into the Nuclei of EGFR Overexpressing Cells via Modular Nanotransporters With Anti-EGFR Affibody

Frontiers in Pharmacology, 2020
Since cell nucleus is one of the most vulnerable compartments, the maximum therapeutic effect from a variety of locally acting agents, such as photosensitizers, alfa-emitters, Auger electron emitters, will be expected when they get there.
Tatiana S. Karyagina, Alexey V. Ulasov, Tatiana A. Slastnikova, Andrey A. Rosenkranz, Andrey A. Rosenkranz, Tatiana N. Lupanova, Yuri V. Khramtsov, Georgii P. Georgiev, Alexander S. Sobolev, Alexander S. Sobolev   +9 more
doaj   +1 more source

Chromothripsis—Explosion in Genetic Science

Cells, 2021
Chromothripsis has been defined as complex patterns of alternating genes copy number changes (normal, gain or loss) along the length of a chromosome or chromosome segment (International System for Human Cytogenomic Nomenclature 2020).
Mariia Shorokhova, Nikolay Nikolsky, Tatiana Grinchuk   +2 more
doaj   +1 more source