Results 251 to 260 of about 22,711 (279)
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Intranasal Drug Delivery to the Brain
2013Drug delivery into the central nervous system (CNS) compartment is often restricted by the blood–brain barrier (BBB) and blood–cerebrospinal fluid barriers (BCSFB) that separate the blood from brain interstitial and cerebrospinal fluids, respectively.
Jeffrey J. Lochhead, Robert G. Thorne
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Formulation of Polymeric Nanoparticles of Antidepressant Drug for Intranasal Delivery
Therapeutic Delivery, 2019Aim: The manuscript describes the performance of nanoparticles loaded with antidepressant drug for nose-to-brain drug delivery. Materials & methods: Poly-lactic-co-glycolic acid-loaded nanoparticles of agomelatine were prepared by nanoprecipitation method using poloxamer 407 as stabilizer.
Parva, Jani +3 more
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Intranasal Delivery—Modification of Drug Metabolism and Brain Disposition
Pharmaceutical Research, 2010Intranasal route continues to be one of the main focuses of drug delivery research. Although it is generally perceived that the nasal route could avoid the first-pass metabolism in liver and gastrointestinal tract, the role of metabolic conversions in systemic and brain-targeted deliveries of the parent compounds and their metabolites should not be ...
Yin Cheong, Wong, Zhong, Zuo
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Navigating the challenges in pediatric intranasal drug delivery
Expert Opinion on Drug DeliveryPediatric intranasal (IN) drug delivery is a promising noninvasive way of administering medication, offering a significant improvement over parenteral and oral methods. However, its effectiveness is hindered by major technical challenges, primarily stemming from the wide anatomical variations among children and the difficulty in achieving consistent ...
Xiomara, Owen +2 more
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Vesicular Systems for Intranasal Drug Delivery
2009Recently, the nasal route for systemic drug delivery has gained great interest. It provides several advantages over other routes of drug administrations. These include rapid absorption, avoidance of the intestinal and hepatic AQ1 presystemic disposition, and high potential for drug transfer to the cerebrospinal fluid.
Ibrahim A. Alsarra +3 more
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Intranasal Drug Delivery System: A Review
Research Journal of Science and TechnologyIntranasal drug delivery is an innovative and non-invasive approach that has garnered increasing attention for its potential to enhance therapeutic efficacy in various disease conditions. This abstract provides a comprehensive overview of the advantages, challenges, and recent developments in intranasal drug delivery systems (INDDS).
Bharat Bava, Kruti Sharma, Vikas Yadav
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Intranasal drug delivery: reality and prospects
Russian RhinologyCurrently, intranasal administration of drugs is one of the promising directions in medicine. This method has a number of essential advantages, which make it attractive for treatment of various diseases. Superior bioavailability, rapid onset of pharmacological effect, absence of «first-pass effect» are among them.
G.V. Lavrenova, K.A. Oganyan
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Intranasal drug delivery for systemic medications.
Critical reviews in therapeutic drug carrier systems, 1988This article is designed to provide a critical literature review on the scientific advances in intra- and transnasal drug delivery for systemic medication. The article discusses the fundamentals, developmental concepts, and biomedical assessment of the transnasal administration of systemically effective drugs which are either easily inactivated when ...
Y W, Chien, S F, Chang
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