Results 1 to 10 of about 119,000 (243)

Comparative Efficacy of Addition of Fentanyl and Neostigmine to Isobaric 0.75% Ropivacaine in Elderly Patients undergoing Transurethral Resection of Prostate under Spinal Anaesthesia: A Double-blinded Randomised Clinical Study [PDF]

Journal of Clinical and Diagnostic Research, 2022
Introduction: Ropivacaine is a well-accepted local anaesthetic drug used in spinal and peripheral nerve blocks. It provides a better Central Nervous System (CNS) and cardiovascular stability in comparison to bupivacaine. Adjuvants are also added with
Pragya Shukla, Sandeep Loha, Ravi Kumar Verma   +2 more
doaj   +1 more source

Comparison of addition of fentanyl or clonidine to Intrathecal bupivacaine versus Intrathecal bupivacaine alone for lower limb surgeries in elderly patients: A prospective, randomised study: Intrathecal fentanyl/clonidine ± bupivacaine for surgery in elderly [PDF]

Serbian Journal of Anesthesia and Intensive Therapy, 2023
Orthopaedic long bone fracture surgeries in elderly patients have their own inherent risks during anaesthesia. We aimed to compare the effect of adding clonidine or fentanyl to low dose intrathecal bupivacaine as opposed to intrathecal bupivacaine alone.
Bhat Pai Rohini V., Kamat Gayatri, Pai Raikar Rukmi, Betkar Sancheeta, Danika Fernandes Bijal, Desai Siddhi   +5 more
doaj   +1 more source

Height-adjusted dose of intrathecal bupivacaine on surgical anesthesia for the cesarean section

Journal of Obstetric Anaesthesia and Critical Care, 2023
Background: In the spinal anesthetic technique, local anesthetic dose (concentration and volume) is the main determinant of its adequacy and success of block to be achieved.
Noyomi Saring, Tomar Basar, Ramapati Sanyal, Mihin Nania   +3 more
doaj   +1 more source

Intravenous immunoglobulin prevents peripheral liver transduction of intrathecally delivered AAV vectors

Molecular Therapy: Methods & Clinical Development, 2022
Gene therapy using neurotropic adeno-associated virus vectors represents an emerging solution for genetic disorders affecting the central nervous system. The first approved central nervous system-targeting adeno-associated virus gene therapy, Zolgensma®,
Makoto Horiuchi, Christian J. Hinderer, Jenny A. Greig, Cecilia Dyer, Elizabeth L. Buza, Peter Bell, Jessica A. Chichester, Peter M. Hayashi, Hanying Yan, Tamara Goode, James M. Wilson   +10 more
doaj   +1 more source

Progressive Lower Extremity Paralysis Caused by Intrathecal MTX-Induced Myelopathy Mimicking Guillain–Barre Syndrome: A Case Report

Diagnostics, 2023
Methotrexate (MTX) is commonly used in intrathecal chemotherapy for patients with acute lymphocytic leukemia (ALL) to prevent central nervous system (CNS) involvement.
Eun Chae Lee, Dong Gyu Lee
doaj   +1 more source

Successful Treatment of Isolated Central Nervous System Relapse with Intrathecal Chemotherapy in an Adolescent with Acute Promyelocytic Leukemia

Clinical Pediatric Hematology-Oncology, 2022
Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML) characterized by translocation of chromosomes 15 and 17 (t(15;17)), which rarely occurs in the pediatric population.
Haerim Song, Eun Sang Yi
doaj   +1 more source

Comparative efficacy and safety of intrathecal ropivacaine versus intrathecal bupivacaine in patients undergoing lower abdominal surgical procedures

Indian Journal of Pain, 2020
Objective: The objective of the study was to compare the efficacy and safety of intrathecal ropivacaine versus intrathecal bupivacaine as anesthetic agents in patients undergoing lower abdominal surgeries.
Prasenjit Adhikari, Varsha Vyas, Shahbaz Naseem, Ulpesh Shelke   +3 more
doaj   +1 more source

Effects of fadolmidine, an α2‐adrenoceptor agonist, as an adjuvant to spinal bupivacaine on antinociception and motor function in rats and dogs

Pharmacology Research & Perspectives, 2021
α2‐Adrenoceptor agonists such as clonidine and dexmedetomidine are used as adjuvants to local anesthetics in regional anesthesia. Fadolmidine is an α2‐adrenoceptor agonist developed especially as a spinal analgesic.
Tiina Leino, Timo Viitamaa, Jarmo S. Salonen, Ullamari Pesonen, Antti Haapalinna   +4 more
doaj   +1 more source

A comparative study of the effect of clonidine, fentanyl, and the combination of both as adjuvant to intrathecal bupivacaine for postoperative analgesia in total abdominal hysterectomy

Journal of Anaesthesiology Clinical Pharmacology, 2017
Background and Aims: The aim of this study was to evaluate the level of sensory block, onset and duration of motor block, postoperative analgesia, and adverse effects of combination of clonidine and fentanyl given intrathecally with hyperbaric ...
Fareed Ahmed, Mamta Khandelwal, Anil Sharma   +2 more
doaj   +1 more source

Intrathecal 99mTc‐DTPA imaging of molecular passage from lumbar cerebrospinal fluid to brain and periphery in humans

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020
Introduction Cerebrospinal fluid (CSF) molecular exchange with brain interstitial fluid (ISF) and periphery is implicated in neurological disorders but needs better quantitative clinical assessment approaches.
Ajay Verma, Jacob Y. Hesterman, J. Levi Chazen, Robert Holt, Patrick Connolly, Laura Horky, Shankar Vallabhajosula, P. David Mozley   +7 more
doaj   +1 more source