Results 161 to 170 of about 99,994 (292)

Trafficking and potentiation of Nav1.7 and Nav1.8 channels are mediated by IQGAP1

The Journal of Physiology, EarlyView.
Abstract figure legend IQGAP1 binds to the voltage‐gated Nav1.7 and Nav1.8 channels and TRPA1 channels in sensory neurons. Inflammatory mediators (IM), including PGE2 and TNFα, released during nerve injury and inflammation activate intracellular signalling messengers such as PKA, p38 MAPK and Cdc42 through their respective receptors.
Xuming Zhang, Pabitra Hriday Patra, Jinquan Yang   +2 more
wiley   +1 more source

Efficacy and Safety of Baclofen 40 mg/20 mL in an Intrathecal Infusion System. [PDF]

Life (Basel)
Marvulli R, Gervasi S, Lagioia G, Dell'Olio L, Caforio Montesardo S, Megna M, Ranieri M.   +6 more
europepmc   +1 more source

CPX‐351 in High‐Risk Relapsed Pediatric Acute Leukemia: Real‐World Phase 1 Data Establishing the FDA‐Approved Dose

Pediatric Blood &Cancer, Volume 73, Issue 6, June 2026.
ABSTRACT Background/Objectives Outcomes for pediatric relapsed/refractory (R/R) acute myeloid leukemia (AML) remain dismal. CPX‐351, a liposomal formulation of cytarabine and daunorubicin, may have less off‐target toxicities than traditional chemotherapies and has shown improved outcomes for adults with newly diagnosed therapy‐related AML.
Jonathan D. Bender, Lauren Pommert, Lori R. Backus, Andrea Bidwell, Courtney Blank, Erin H. Breese, Karen C. Burns, Adam Lane, Lynn H. Lee, Benjamin Mizukawa, Robin E. Norris, Maureen M. O'Brien, Daniel Peck, Christine Phillips, Thomas D. Ryan, Jennifer Young, Michael Absalon, John P. Perentesis   +17 more
wiley   +1 more source

Intrathecal adjuvants in spinal anaesthesia: Balancing evidence, safety, and regulatory gaps. [PDF]

Indian J Anaesth
Khan IA, Karim HMR.
europepmc   +1 more source

Relaxivity of Gadobutrol and Gadoteric Acid in Cerebrospinal Fluid at 3T

Magnetic Resonance in Medicine, Volume 95, Issue 6, Page 3409-3415, June 2026.
ABSTRACT Purpose The aim was to estimate T1 relaxivity of gadobutrol and gadoteric acid in cerebrospinal fluid (CSF) at 3T, to support research on CSF‐flow and the glymphatic system in humans utilizing T1 mapping after intrathecal injection. Methods Using a phantom, relaxivity was estimated for gadobutrol and gadoteric acid in lumbar CSF and an ...
Sofia Behndig, Anders Garpebring, Daniel Dahlgren Lindström, Jan Malm, Anders Wåhlin, Anders Eklund   +5 more
wiley   +1 more source

Effect of Intrathecal Hydromorphone on the Duration and Efficacy of Postoperative Analgesia in Patients Undergoing Benign Anorectal Surgery: Protocol for a Randomized, Double-Blind, Controlled Trial. [PDF]

J Pain Res
Cao Y, Zhou Y, Zhou D, Xiong C, Fu L, Chen X, Zhang X.   +6 more
europepmc   +1 more source

Rapid Tissue‐CSF Water Exchange in the Human Brain Revealed by Magnetization Transfer Indirect Spin Labeling

Magnetic Resonance in Medicine, Volume 95, Issue 6, Page 3270-3283, June 2026.
ABSTRACT Purpose To apply the Magnetization Transfer Indirect Spin Labeling (MISL) MRI technique for quantifying tissue‐CSF water exchange in the human brain, and to investigate its utility in (1) evaluating tissue‐CSF water exchange within perivascular spaces (PVS), and (2) characterizing altered water exchange dynamics in pathologic conditions ...
Yihan Wu, Kexin Wang, Licheng Ju, Anna Li, Qin Qin, Feng Xu, Doris D. M. Lin, Lawrence Kleinberg, Jiadi Xu   +8 more
wiley   +1 more source

Kappa free light chain index in CSF diagnostics: the impact of different immunoglobulin isotypes. [PDF]

Front Immunol
Schmidauer M, Berek K, Auer M, Di Pauli F, Föttinger F, Krajnc N, Deisenhammer F, Bsteh G, Walde J, Hegen H.   +9 more
europepmc   +1 more source

Risdiplam Add‐On Therapy Following Onasemnogene Abeparvovec in Children With Spinal Muscular Atrophy and 2 SMN2 Copies: A Multi‐Center Case Series

Muscle &Nerve, Volume 73, Issue 6, Page 1164-1171, June 2026.
ABSTRACT Introduction/Aims Three disease‐modifying therapies are approved for individuals with spinal muscular atrophy (SMA); however, data concerning the combination of these therapies remain limited. This study aimed to evaluate the safety and efficacy of add‐on risdiplam in children who had experienced clinical deterioration despite gene therapy ...
Corinna Stoltenburg, Klaus Goldhahn, Arpad von Moers, Angela M. Kaindl, Claudia Weiß   +4 more
wiley   +1 more source

A Hospitalist-Run Procedure Service Safely Streamlines Inpatient Intrathecal Chemotherapy. [PDF]

Cureus
Ghanem G, Malone A, Chen L, Feigenbaum GS, Glaeser AM.   +4 more
europepmc   +1 more source