Results 61 to 70 of about 119,000 (243)

Improved MECP2 Gene Therapy Extends the Survival of MeCP2-Null Mice without Apparent Toxicity after Intracisternal Delivery

Molecular Therapy: Methods & Clinical Development, 2017
Intravenous administration of adeno-associated virus serotype 9 (AAV9)/hMECP2 has been shown to extend the lifespan of Mecp2−/y mice, but this delivery route induces liver toxicity in wild-type (WT) mice.
Sarah E. Sinnett, Ralph D. Hector, Kamal K.E. Gadalla, Clifford Heindel, Daphne Chen, Violeta Zaric, Mark E.S. Bailey, Stuart R. Cobb, Steven J. Gray   +8 more
doaj   +1 more source

Comparative study between the effect of intravenous or intrathecal dexmedetomidine on bupivacaine spinal block in lower abdominal surgery

Al-Azhar Assiut Medical Journal
Background and aim Dexmedetomidine has been shown to prolong spinal anesthesia and enhance postoperative analgesia when given intravenously or intrathecally.
Hayam S. Soliman, Ezzat M.A. Al-Saudi, Ahmed A. Mansour   +2 more
doaj   +1 more source

Painless intrathecal hypertonic saline [PDF]

Canadian Anaesthetists’ Society Journal, 1974
Hypertonic saline, when injected into the lumbar subarachnoid space for the relief of intractable pain, causes pain, unpleasant muscle cramps and potentially dangerous sympathetic discharge. These side effects can be avoided by adding a weak concentration of local anaesthetic to the brine solution.
A W, Squire, O, Calvillo, P R, Bromage
openaire   +2 more sources

Management of spasticity with intrathecal phenol injections: The past and the present

The Journal of the International Society of Physical and Rehabilitation Medicine, 2019
Introduction: Spasticity is increased, involuntary, velocity-dependent muscle tone that causes resistance to movement. Intrathecal injection of phenol is a form of treatment used in a very selective group of patients with spasticity. Aim: This study aims
Fahim Anwar, Silvia Antiga, Harry Mee, Ahmad Al Khayer   +3 more
doaj   +1 more source

Local BDNF Delivery to the Injured Cervical Spinal Cord using an Engineered Hydrogel Enhances Diaphragmatic Respiratory Function. [PDF]

, 2018
We developed an innovative biomaterial-based approach to repair the critical neural circuitry that controls diaphragm activation by locally delivering brain-derived neurotrophic factor (BDNF) to injured cervical spinal cord.
Ghosh, Biswarup, Lepore, Angelo C., Nong, Jia, Trovillion, Victoria A., Urban, Mark W., Wang, Zhicheng, Wright, Megan C., Zhang, Zhiling, Zhong, Yinghui   +8 more
core   +2 more sources

Intrathecal/Intraventricular Linezolid in Multidrug-Resistant Enterococcus faecalis Ventriculitis

Journal of Neurological Surgery Reports, 2016
Background The use of intrathecal antibiotic therapy for the treatment of ventriculitis and/or meningitis has demonstrated efficacy especially when sterilization of the cerebrospinal fluid is not possible with intravenous antibiotics alone ...
Brian F. Lich, Andrew K. Conner, Joshua D. Burks, Chad A. Glenn, Michael E. Sughrue   +4 more
doaj   +1 more source

Intrathecal use of amikacin: a case report

Brazilian Journal of Infectious Diseases
Meningitis caused by Acinetobacter baumannii is rare and are mostly hospital acquired after neurosurgical procedure. We report a case of a 40-year old man was admitted to the intensive care unit due to subarachnoid haemorrhage.
L. Barrou, B. Charra, A. Hachimi, B. Idali, A. Benslama, S. Motaouakkil   +5 more
doaj   +1 more source

The effect of addition of intrathecal clonidine to hyperbaric bupivacaine on postoperative pain after lower segment caesarean section: A randomized control trial

Saudi Journal of Anaesthesia, 2013
Background: Intrathecal clonidine prolongs spinal anesthesia but the optimum dose to be used in cesarean delivery is not yet known. We evaluated the effect of addition of intrathecal clonidine to hyperbaric bupivacaine on postoperative pain after lower ...
Ranju Singh, Deepti Gupta, Aruna Jain
doaj   +1 more source

Adeno-associated virus-mediated gene transfer of arginine decarboxylase to the central nervous system prevents opioid analgesic tolerance

Frontiers in Pain Research
Agmatine, a decarboxylated form of L-arginine, prevents opioid analgesic tolerance, dependence, and self-administration when given by both central and systemic routes of administration.
Caroline C. Churchill, Cristina D. Peterson, Cristina D. Peterson, Cristina D. Peterson, Kelley F. Kitto, Kelsey R. Pflepsen, Lalitha R. Belur, R. Scott McIvor, Lucy Vulchanova, George L. Wilcox, George L. Wilcox, George L. Wilcox, Carolyn A. Fairbanks, Carolyn A. Fairbanks, Carolyn A. Fairbanks   +14 more
doaj   +1 more source

Evaluation of the effect of intrathecal clonidine to decrease shoulder tip pain in laparoscopy under spinal anaesthesia

Indian Journal of Anaesthesia, 2010
Sixty ASA grade I/II patients scheduled for elective short laparoscopic procedures under spinal anaesthesia were divided into two groups of 30 each. The first group (group C) received 3.5 ml of hyperbaric bupivacaine with 30 mcg of clonidine.
Poonam S Ghodki, Shalini P Sardesai, Shalini K Thombre   +2 more
doaj   +1 more source