Results 81 to 90 of about 158,913 (343)

Clinically Inspired Multimodal Treatment Using Induced Neural Stem Cells‐Derived Exosomes Promotes Recovery of Traumatic Brain Injury through Microglial Modulation

Advanced Science, EarlyView.
This study explores the therapeutic potential of iNSC‐Exo via local and systemic delivery in TBI mice. It is found that iNSC‐Exo enhances NRXN signaling through Microglia_Nrg3 and Microglia_Rarb, effectively promoting functional and neurological recovery, suggesting a new therapeutic strategy for TBI. Abstract Traumatic brain injury (TBI) poses serious
Jiaojiao Li, Maoxiang Xu, Boyu Cai, Xiangyu Li, Zhanping Liang, Xiaohuan Xia, Haitao Zhang, Zhiwen Zhang, Fei Tan, Jialin Charlie Zheng   +9 more
wiley   +1 more source

Steady streaming confined between three-dimensional wavy surfaces [PDF]

, 2010
We present a theoretical and numerical study of three-dimensional pulsatile confined flow between two rigid horizontal surfaces separated by an average gap h, and having three-dimensional wavy shapes with arbitrary amplitude σ h where σ ∼ O(1), but long ...
Bergeon, Alain, Guibert, Romain, Plouraboué, Franck   +2 more
core   +2 more sources

Hydrogel-based scaffolds to support intrathecal stem cell transplantation as a gateway to the spinal cord: clinical needs, biomaterials, and imaging technologies

npj Regenerative Medicine, 2018
The prospects for cell replacement in spinal cord diseases are impeded by inefficient stem cell delivery. The deep location of the spinal cord and complex surgical access, as well as densely packed vital structures, question the feasibility of the ...
J. Oliveira, L. Carvalho, J. Silva-Correia, S. Vieira, M. Majchrzak, B. Lukomska, L. Stanaszek, Paulina Strymecka, I. Malysz-Cymborska, Dominika Golubczyk, Lukasz Kalkowski, R. Reis, M. Janowski, P. Walczak   +13 more
semanticscholar   +1 more source

A comparative study of intrathecal and epidural buprenorphine using combined spinal-epidural technique for caesarean section

Indian Journal of Anaesthesia, 2010
Neuraxial opioids provide excellent analgesia intraoperatively and postoperatively while allowing early ambulation of the patient by sparing sympathetic and motor nerves. A prospective, randomised double blind study was conducted involving 90 patients of
Shaloo Ipe, Sara Korula, Sreelatha Varma, Grace Maria George, Saramma P Abraham, Leena Rachel Koshy   +5 more
doaj   +1 more source

T1WI‐SWI Dual Modal Magnetic Resonance Nanoprobes for Accurate Diagnosis of Early Stage Alzheimer's Disease

Advanced Science, EarlyView.
We developed a smart MRI nanoprobe targeting BACE1 and Aβ plaques. It crosses the blood‐brain barrier. Upon encountering BACE1, the probe is cleaved, enabling T1WI imaging detection. Subsequent reaction with ONOO− induces probe aggregation, enhancing magnetic susceptibility for sensitive SWI imaging of Aβ plaques.
Minghua Li, Aijun Shen, Xiaolong Gao, Chao Lin, Zongliang Huang, Qi Lv, Junjun Tang, Xiaolong Ma, Jiong Ni, Ju Tian, Jiaqi Wu, Xiaowen Xu, Wei Wang, Peijun Wang   +13 more
wiley   +1 more source

Insufficient disease inhibition by intrathecal rituximab in progressive multiple sclerosis

Annals of Clinical and Translational Neurology, 2016
Inaccessibility of the inflammation compartmentalized to the central nervous system (CNS) may underlie the lack of efficacy of immunomodulatory treatments in progressive multiple sclerosis (MS).
M. Komori, Yen-Chih Lin, I. Cortese, A. Blake, J. Ohayon, Jamie Cherup, D. Maric, P. Kosa, Tianxia Wu, B. Bielekova   +9 more
semanticscholar   +1 more source

Targeting the Dynamics Between TAMs and CAR‐T Cells in Solid Tumor Therapies

Advanced Science, EarlyView.
This review highlights the critical role of tumor‐associated macrophages (TAMs) in affecting CAR‐T cell therapy effectiveness in solid tumors. TAMs contribute to immune suppression through cytokine secretion, immune checkpoint activation, and metabolic reprogramming, leading to CAR‐T cell exhaustion and reduced efficacy. The article explores strategies
Xiang Zhang, Hao Zheng, Zi‐Chang Liu, Ling‐Jie Luo, Xiao Dong, Xin‐Gang Cui, Yan‐Wei Wu, Liang Chen   +7 more
wiley   +1 more source

Carbamazepine-responsive paroxysmal nausea and vomiting in a patient with meningeal carcinomatosis [PDF]

, 2006
In neurology, paroxysmal syndromes are well-known, eg, as manifestations of multiple sclerosis. We report a patient with meningeal carcinomatosis, who presented with therapyrefractory nausea and vomiting.
Borasio, Gian Domenico
core   +1 more source

Intrathecal Drug Delivery Systems Survey: Trends in Utilization in Pain Practice [Corrigendum]

Journal of Pain Research, 2023
Abd-Sayed A, Fiala K, Weisbein J, et al. J Pain Res. 2022;15:1305–1314. The authors have advised there is an error in the author list on page 1305. The author name “Alaa Abd-Sayed” should read “Alaa Abd-Elsayed”.
Abd-Sayed A, Fiala K, Weisbein J, Chopra P, Lam C, Kalia H, Jassal N, Gulati A, Sayed D, Deer T   +9 more
doaj  

A Supramolecular Nanoscavengers: Based “Cargo‐Exchange” Breaking Cholesterol Metabolic Dysregulation for Glioblastoma Therapy

Advanced Science, EarlyView.
Dysregulated cholesterol metabolism, driven by a complex array of mechanisms, is a defining characteristic of glioblastoma (GBM). In this study, supramolecular nanoscavengers are engineered by harnessing the intrinsic binding affinity between endogenous small‐molecule cholesterol and β‐cyclodextrin (β‐CD).
Zonghua Tian, Yun Chen, Jingyi Zhou, Shilin Zhang, Hongrui Fan, Xuwen Li, Tao Sun, Chen Jiang   +7 more
wiley   +1 more source