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Intrinsic disorder in S100 proteins
Molecular BioSystems, 2011Abstract Although the members of the largest subfamily of the EF-hand proteins, S100 proteins, are evolutionarily young, their functional diversity is extremely broad, partly due to their ability to adapt to various targets. This feature is a hallmark of intrinsically disordered proteins (IDPs), but none of the S100 proteins are ...
Sergei E, Permyakov +5 more
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Intrinsic Fluorescence of Intrinsically Disordered Proteins
2012Resolution of the intrinsic emission properties of a protein by different fluorescence spectroscopy techniques is an invaluable tool to detect and characterize its structural architecture and conformational changes under different experimental conditions.
NEYROZ, PAOLO, CIURLI, STEFANO LUCIANO
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Intrinsically disordered proteins
Molecular BioSystems, 2011M. Madan Babu introduces this Molecular BioSystems themed issue on intrinsically disordered proteins.
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Intrinsically Disordered Proteins: An Update
2007 IEEE 7th International Symposium on BioInformatics and BioEngineering, 2007Just over 10 years ago, in June, 1997, in the Proceedings of the IEEE International Conference on Neural Networks, we published our first predictor of intrinsically disordered protein. Since then, we have substantially improved our predictors, and more than 20 other laboratory groups have joined in efforts to improve the prediction of protein disorder.
A. Keith Dunker +6 more
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Intrinsic Disorder in Ubiquitination Substrates
Journal of Molecular Biology, 2011The ubiquitin-proteasome system is responsible for the degradation of numerous proteins in eukaryotes. Degradation is an essential process in many cellular pathways and involves the proteasome degrading a wide variety of unrelated substrates while retaining specificity in terms of its targets for destruction and avoiding unneeded proteolysis.
Tzachi, Hagai +3 more
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2019
This volume gives voice to queer people from all faiths and no faiths, and their heterosexual allies, describing their experiences with spiritual violence and inclusion. It includes personal narratives, theoretical insights, and creative writing, highlighting stories of pain, rejection, joy, and transformation.
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This volume gives voice to queer people from all faiths and no faiths, and their heterosexual allies, describing their experiences with spiritual violence and inclusion. It includes personal narratives, theoretical insights, and creative writing, highlighting stories of pain, rejection, joy, and transformation.
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Druggability of Intrinsically Disordered Proteins
2015Although the proteins in all the current major classes considered to be druggable are folded in their native states, intrinsically disordered proteins (IDPs) are becoming attractive candidates for therapeutic intervention by small drug-like molecules.
Priyanka, Joshi, Michele, Vendruscolo
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Translocation of polyampholytes and intrinsically disordered proteins⋆
The European Physical Journal E, 2018Polyampholytes are polymers carrying electrical charges of both signs along their backbone. We consider synthetic polyampholytes with a quenched random charge sequence and intrinsically disordered proteins, which have a well-defined charge sequence and behave like polyampholytes in the denaturated state.
Johner, Albert, Joanny, Jean-François
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Intrinsically disordered proteins: regulation and disease
Current Opinion in Structural Biology, 2011Intrinsically disordered proteins (IDPs) are enriched in signaling and regulatory functions because disordered segments permit interaction with several proteins and hence the re-use of the same protein in multiple pathways. Understanding IDP regulation is important because altered expression of IDPs is associated with many diseases. Recent studies show
Babu, M.M. +3 more
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Intrinsically disordered CO2 sensors
Nature Cell Biology, 2022Ryan J. Emenecker, Alex S. Holehouse
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