Results 271 to 280 of about 2,160,956 (299)

Intrinsic Disorder in Ubiquitination Substrates

Journal of Molecular Biology, 2011
The ubiquitin-proteasome system is responsible for the degradation of numerous proteins in eukaryotes. Degradation is an essential process in many cellular pathways and involves the proteasome degrading a wide variety of unrelated substrates while retaining specificity in terms of its targets for destruction and avoiding unneeded proteolysis.
Tzachi, Hagai, Ariel, Azia, Ágnes, Tóth-Petróczy, Yaakov, Levy   +3 more
openaire   +2 more sources

“Intrinsic Disorder”

2019
This volume gives voice to queer people from all faiths and no faiths, and their heterosexual allies, describing their experiences with spiritual violence and inclusion. It includes personal narratives, theoretical insights, and creative writing, highlighting stories of pain, rejection, joy, and transformation.
openaire   +1 more source

Druggability of Intrinsically Disordered Proteins

2015
Although the proteins in all the current major classes considered to be druggable are folded in their native states, intrinsically disordered proteins (IDPs) are becoming attractive candidates for therapeutic intervention by small drug-like molecules.
Priyanka, Joshi, Michele, Vendruscolo
openaire   +2 more sources

Translocation of polyampholytes and intrinsically disordered proteins⋆

The European Physical Journal E, 2018
Polyampholytes are polymers carrying electrical charges of both signs along their backbone. We consider synthetic polyampholytes with a quenched random charge sequence and intrinsically disordered proteins, which have a well-defined charge sequence and behave like polyampholytes in the denaturated state.
Johner, Albert, Joanny, Jean-François
openaire   +3 more sources

Intrinsically disordered proteins: regulation and disease

Current Opinion in Structural Biology, 2011
Intrinsically disordered proteins (IDPs) are enriched in signaling and regulatory functions because disordered segments permit interaction with several proteins and hence the re-use of the same protein in multiple pathways. Understanding IDP regulation is important because altered expression of IDPs is associated with many diseases. Recent studies show
Babu, M.M., Lee, R.T.J.G. van der, Groot, N.S. de, Gsponer, J.   +3 more
openaire   +2 more sources

Intrinsically disordered CO2 sensors

Nature Cell Biology, 2022
Ryan J. Emenecker, Alex S. Holehouse
openaire   +2 more sources

Epigenetics: Future Prospective in Human Disorders and Therapeutics

Medical Epigenetics, 2021
Shriram N Rajpathak
exaly  

Epigenetics in Bone and Joint Disorders

Medical Epigenetics, 2021
V Nagaraja
exaly  

Epigenetics of Skin Disorders

Medical Epigenetics, 2021
Qianjin Lu, Shuaihantian Luo
exaly  

Epigenetics of Muscle Disorders

Medical Epigenetics, 2021
Elisa Oltra
exaly