Results 11 to 20 of about 325,795 (314)
Journal of Advanced Research, 2021 Introduction: Ca2+-activated Cl− channel TMEM16A is expressed in endothelial cells, and contributes to many diseases such as hypertension, blood-brain barrier dysfunction, and pulmonary hypertension.
Ke Ma +10 more
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Thorax, 2013 Effective therapies for the 10% of patients with 'severe' asthma remain elusive, while other pulmonary diseases such as idiopathic pulmonary fibrosis are currently untreatable. Many cellular processes rely heavily on signals delivered by changes in the intracellular-free Ca(2+) concentration, in many cases relying on Ca(2+) influx from the ...
Peter, Bradding, Heike, Wulff
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British Journal of Pharmacology, 2007 ALEXANDER, S.P.H., MATHIE, A. & PETERS, J.A. (2007). Guide to Receptors and Channels (GRAC), 2nd edition (2007 revision). Br. J. Pharmacol., 150 (Suppl. 1), S1–S168.
S P H Alexander, A Mathie, J A Peters
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Activation of TMEM16A Ca2+-activated Cl− channels by ROCK1/moesin promotes breast cancer metastasis
Journal of Advanced Research, 2021 Introduction: Transmembrane protein 16A (TMEM16A) is a Ca2+-activated chloride channel that plays a role in cancer cell proliferation, migration, invasion, and metastasis.
Shuya Luo +13 more
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Diabetologia, 1992 Insulin secretion by the pancreatic Beta cell is dependent upon transmembrane ion fluxes gated by the ATP-regulated potassium channel and the voltage regulated, L-type calcium channel. This work group examined major recent advances in the structure and modulation of ion channels and how those advances may pertain to the physiology of insulin secretion ...
W, Catterall, P N, Epstein
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Continuous glucose monitoring during pregnancy in healthy mice
Scientific Reports, 2021 During pregnancy, metabolic adaptations occur to maintain the balance between maternal and foetal growth, including increased insulin secretion and decreased insulin sensitivity. When the body fails to adjust, gestational diabetes mellitus develops.
Caroline Wuyts +4 more
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Journal of Advanced Research, 2020 TMEM16A Ca2+-activated Cl− channels are expressed in pancreatic acinar cells and participate in inflammation-associated diseases. Whether TMEM16A contributes to the pathogenesis of acute pancreatitis (AP) remains unknown.
Qinghua Wang +13 more
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Frontiers in Molecular Biosciences, 2022 Intracellular pH is a vital parameter that is maintained close to neutrality in all mammalian cells and tissues and acidic in most intracellular compartments.
Denis Doyen +16 more
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Triggering the Amphotericin B Pore-Forming Activity by Phytochemicals
Membranes, 2023 The macrolide polyene antibiotic amphotericin B (AmB), remains a valuable drug to treat systemic mycoses due to its wide antifungal activity and low probability of developing resistance.
Svetlana S. Efimova +2 more
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Human Molecular Genetics, 2002 Ion channels serve many functions apart from electrical signal transduction: chemical signalling (Ca(2+) as a second messenger), transepithelial transport, regulation of cytoplasmic or vesicular ion concentration and pH, and regulation of cell volume. Therefore, ion channel dysfunction can cause diseases in many tissues.
Christian A, Hübner, Thomas J, Jentsch
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