Results 11 to 20 of about 1,025,431 (370)
Frontiers in Molecular Biosciences, 2022 Intracellular pH is a vital parameter that is maintained close to neutrality in all mammalian cells and tissues and acidic in most intracellular compartments.
Denis Doyen +16 more
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Ion Channel Pharmacology [PDF]
Neurotherapeutics, 2007 Because ion channels are involved in many cellular processes, drugs acting on ion channels have long been used for the treatment of many diseases, especially those affecting electrically excitable tissues. The present review discusses the pharmacology of voltage-gated and neurotransmitter-gated ion channels involved in neurologic diseases, with ...
CONTE, Diana +2 more
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Frontiers in Cardiovascular Medicine, 2023 BackgroundAcute myocardial infarction (AMI) is the major cause of cardiovascular mortality worldwide. Most ischemic episodes are triggered by an increase in heart rate, which induces an imbalance between myocardial oxygen delivery and consumption ...
Viviana Delgado-Betancourt +26 more
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Triggering the Amphotericin B Pore-Forming Activity by Phytochemicals
Membranes, 2023 The macrolide polyene antibiotic amphotericin B (AmB), remains a valuable drug to treat systemic mycoses due to its wide antifungal activity and low probability of developing resistance.
Svetlana S. Efimova +2 more
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The Role of the Dielectric Barrier in Narrow Biological Channels: a Novel Composite Approach to Modeling Single-channel Currents [PDF]
, 2003 A composite continuum theory for calculating ion current through a protein channel of known structure is proposed, which incorporates information about the channel dynamics. The approach is utilized to predict current through the Gramicidin A ion channel,
Coalson, Rob D. +3 more
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Langmuir, 2013 The objective of this historical review is to recall the development of the field of synthetic ion channels over the past three decades. The most inspiring and influential breakthroughs with regard to structure and function are brought together to give the general reader an easily accessible understanding of the field.
Sakai Naomi, Matile Stefan
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Annual Review of Biophysics, 2023 Mitochondria are involved in multiple cellular tasks, such as ATP synthesis, metabolism, metabolite and ion transport, regulation of apoptosis, inflammation, signaling, and inheritance of mitochondrial DNA. The majority of the correct functioning of mitochondria is based on the large electrochemical proton gradient, whose component, the inner ...
Szabo I., Szewczyk A.
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Definition of two agonist types at the mammalian cold-activated channel TRPM8
eLife, 2016 Various TRP channels act as polymodal sensors of thermal and chemical stimuli, but the mechanisms whereby chemical ligands impact on TRP channel gating are poorly understood.
Annelies Janssens +8 more
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Self-organized enhancement of conductivity in biological ion channels [PDF]
, 2013 We discuss an example of self-organization in a biological system. It arises from long-range ion–ion interactions, and it leads us to propose a new kind of enhanced conduction in ion channels.
Eisenberg, Robert S. +5 more
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Journal of Advanced Research, 2021 Introduction: Ca2+-activated Cl− channel TMEM16A is expressed in endothelial cells, and contributes to many diseases such as hypertension, blood-brain barrier dysfunction, and pulmonary hypertension.
Ke Ma +10 more
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