Results 1 to 10 of about 100,331 (293)
Energetic contributions to channel gating of residues in the muscle nicotinic receptor β1 subunit. [PDF]
PLoS ONE, 2013 In the pentameric ligand-gated ion channel family, transmitter binds in the extracellular domain and conformational changes result in channel opening in the transmembrane domain.
Gustav Akk +5 more
doaj +6 more sources
Polyunsaturated fatty acids modify the gating of Kv channels [PDF]
Frontiers in Pharmacology, 2012 Polyunsaturated fatty acids (PUFAs) have been reported to exhibit antiarrhythmic properties, which are attributed to their capability to modulate ion channels.
Cristina eMoreno +4 more
doaj +3 more sources
MicroED structure of the NaK ion channel reveals a Na+ partition process into the selectivity filter [PDF]
Communications Biology, 2018 Through a MicroED structure of NaK ion channel, Shian Liu and Tamir Gonen identify a process of dilation coupled with Na+ movement, providing mechanistic insights into ion conduction and gating.
Shian Liu, Tamir Gonen
doaj +3 more sources
Structure, dynamics and implied gating mechanism of a human cyclic nucleotide-gated channel. [PDF]
PLoS Computational Biology, 2014 Cyclic nucleotide-gated (CNG) ion channels are nonselective cation channels, essential for visual and olfactory sensory transduction. Although the channels include voltage-sensor domains (VSDs), their conductance is thought to be independent of the ...
Yana Gofman +4 more
doaj +5 more sources
Voltage-Gated Ion Channels [PDF]
IEEE Transactions on Nanobioscience, 2005 Voltage-dependent ion channels are membrane proteins that conduct ions at high rates regulated by the voltage across the membrane. They play a fundamental role in the generation and propagation of the nerve impulse and in cell homeostasis. The voltage sensor is a region of the protein bearing charged amino acids that relocate upon changes in the ...
Sands, Z, Grottesi, A, Sansom, MS
+7 more sources
Unmasking coupling between channel gating and ion permeation in the muscle nicotinic receptor
eLife, 2021 Whether ion channel gating is independent of ion permeation has been an enduring, unresolved question. Here, applying single channel recording to the archetypal muscle nicotinic receptor, we unmask coupling between channel gating and ion permeation by ...
John R Strikwerda, Steven M Sine
doaj +1 more source
Nature Communications, 2022 Visualizing conformational changes during ion channel gating is crucial to understand their regulation. Here, Gao et al. capture multiple gating intermediates in a CNG channel as well as subtle, lateral voltage sensor movements necessary for channel ...
Xiaolong Gao +6 more
doaj +1 more source
Central cavity dehydration as a gating mechanism of potassium channels
Nature Communications, 2023 The hydrophobic gating model, in which ion permeation is inhibited by the hydrophobicity, rather than a physical occlusion of the nanopore, functions in various ion channels including potassium channels.
Ruo-Xu Gu, Bert L. de Groot
doaj +1 more source
Artificial modulation of the gating behavior of a K+ channel in a KvAP-DNA chimera. [PDF]
PLoS ONE, 2011 We present experiments where the gating behavior of a voltage-gated ion channel is modulated by artificial ligand binding. We construct a channel-DNA chimera with the KvAP potassium channel reconstituted in an artificial membrane.
Andrew Wang, Giovanni Zocchi
doaj +1 more source
Voltage Gated Lipid Ion Channels [PDF]
Biophysical Journal, 2013 10 pages, 7 figures - Strongly revised version compared to first version.
Blicher, Andreas +1 more
openaire +7 more sources