Results 21 to 30 of about 57,056 (243)
Effects of ionic strength on gating and permeation of TREK-2 K2P channels.
PLoS ONE, 2021 In addition to the classical voltage-dependent behavior mediated by the voltage-sensing-domains (VSD) of ion channels, a growing number of voltage-dependent gating behaviors are being described in channels that lack canonical VSDs.
Linus J Conrad +2 more
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Transcending Markov: non-Markovian rate processes of thermosensitive TRP ion channels
Royal Society Open Science, 2023 The Markov state model (MSM) is a popular theoretical tool for describing the hierarchy of time scales involved in the function of many proteins especially ion channel gating. An MSM is a particular case of the general non-Markovian model, where the rate
Yuval Ben-Abu +2 more
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PLoS Computational Biology, 2010 Neuronal activity is mediated through changes in the probability of stochastic transitions between open and closed states of ion channels. While differences in morphology define neuronal cell types and may underlie neurological disorders, very little is ...
Robert C Cannon +2 more
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Monod-Wyman-Changeux Analysis of Ligand-Gated Ion Channel Mutants [PDF]
, 2017 We present a framework for computing the gating properties of ligand-gated ion channel mutants using the Monod-Wyman-Changeux (MWC) model of allostery. We derive simple analytic formulas for key functional properties such as the leakiness, dynamic range,
Einav, Tal, Phillips, Rob
core +4 more sources
Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel
eLife, 2019 TRPM2 is critically involved in diverse physiological processes including core temperature sensing, apoptosis, and immune response. TRPM2’s activation by Ca2+ and ADP ribose (ADPR), an NAD+-metabolite produced under oxidative stress and neurodegenerative
Yihe Huang, Becca Roth, Wei Lü, Juan Du
doaj +1 more source
Piezo’s membrane footprint and its contribution to mechanosensitivity
eLife, 2018 Piezo1 is an ion channel that gates open when mechanical force is applied to a cell membrane, thus allowing cells to detect and respond to mechanical stimulation.
Christoph A Haselwandter +1 more
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An Unorthodox Mechanism Underlying Voltage Sensitivity of TRPV1 Ion Channel
Advanced Science, 2020 While the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1) channel is a polymodal nociceptor for heat, capsaicin, and protons, the channel's responses to each of these stimuli are profoundly regulated by membrane potential, damping or ...
Fan Yang +5 more
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Site-directed spin labeling reveals pentameric ligand-gated ion channel gating motions. [PDF]
PLoS Biology, 2013 Pentameric ligand-gated ion channels (pLGICs) are neurotransmitter-activated receptors that mediate fast synaptic transmission. In pLGICs, binding of agonist to the extracellular domain triggers a structural rearrangement that leads to the opening of an ...
Cosma D Dellisanti +9 more
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Role of the Ion Channel Extracellular Collar in AMPA Receptor Gating
Scientific Reports, 2017 AMPA subtype ionotropic glutamate receptors mediate fast excitatory neurotransmission and are implicated in numerous neurological diseases. Ionic currents through AMPA receptor channels can be allosterically regulated via different sites on the receptor ...
Maria V. Yelshanskaya +3 more
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Hydrophobic Gating in Ion Channels
Journal of Molecular Biology, 2015 Biological ion channels are nanoscale transmembrane pores. When water and ions are enclosed within the narrow confines of a sub-nanometer hydrophobic pore, they exhibit behavior not evident from macroscopic descriptions. At this nanoscopic level, the unfavorable interaction between the lining of a hydrophobic pore and water may lead to stochastic ...
Aryal, P, Sansom, MS, Tucker, S
openaire +3 more sources