Results 21 to 30 of about 5,284,490 (388)
Molecules, 2021 Mitochondria play a key role in energy metabolism within the cell. Potassium channels such as ATP-sensitive, voltage-gated or large-conductance Ca2+-regulated channels have been described in the inner mitochondrial membrane.
Aleksandra Sek +4 more
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British Journal of Pharmacology, 2007 ALEXANDER, S.P.H., MATHIE, A. & PETERS, J.A. (2007). Guide to Receptors and Channels (GRAC), 2nd edition (2007 revision). Br. J. Pharmacol., 150 (Suppl. 1), S1–S168.
S P H Alexander, A Mathie, J A Peters
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Diabetologia, 1992 Insulin secretion by the pancreatic Beta cell is dependent upon transmembrane ion fluxes gated by the ATP-regulated potassium channel and the voltage regulated, L-type calcium channel. This work group examined major recent advances in the structure and modulation of ion channels and how those advances may pertain to the physiology of insulin secretion ...
W, Catterall, P N, Epstein
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Frontiers in Pharmacology, 2023 Neonatal hypoxic-ischemic encephalopathy (HIE) is considered a major cause of death and long-term neurological injury in newborns. Studies have demonstrated that oxidative stress and apoptosis play a major role in the progression of neonatal HIE ...
Yuan Li +8 more
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Mitochondrial Potassium Channels as Druggable Targets
Biomolecules, 2020 Mitochondrial potassium channels have been described as important factors in cell pro-life and death phenomena. The activation of mitochondrial potassium channels, such as ATP-regulated or calcium-activated large conductance potassium channels, may have ...
Antoni Wrzosek +3 more
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Frontiers in Cellular Neuroscience, 2023 The possibilities of using nanoparticle materials based on cerium dioxide (CNPs) are exciting since they are low toxic and have specific redox, antiradical properties.
Vita V. Hanzha +4 more
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Scientific Reports, 2021 The activation of mitochondrial large conductance calcium-activated potassium (mitoBKCa) channels increases cell survival during ischemia/reperfusion injury of cardiac cells.
Shur Gałecka +4 more
doaj +1 more source
TRP Channels Interactome as a Novel Therapeutic Target in Breast Cancer
Frontiers in Oncology, 2021 Breast cancer is one of the most frequent cancer types worldwide and the first cause of cancer-related deaths in women. Although significant therapeutic advances have been achieved with drugs such as tamoxifen and trastuzumab, breast cancer still caused ...
María Paz Saldías +19 more
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SCN1A channelopathies: Navigating from genotype to neural circuit dysfunction
Frontiers in Neurology, 2023 The SCN1A gene is strongly associated with epilepsy and plays a central role for supporting cortical excitation-inhibition balance through the expression of NaV1.1 within inhibitory interneurons.
Alexander Bryson +2 more
doaj +1 more source
Ion Channels in Innate and Adaptive Immunity
Annual Review of Immunology, 2015 stefan Feske +2 more
exaly +2 more sources