Results 21 to 30 of about 4,654,285 (364)
Self-assembled Artificial Ion-Channels toward Natural Selection of Functions.
Angewandte Chemie, 2020 Owing to their significant physiological functions, especially as selective relays for translocation of physiological relevant species through cellular membranes, natural ion channels play important role in the living organisms.
Shaoping Zheng +3 more
semanticscholar +1 more source
Ion Channels in the Heart [PDF]
Comprehensive Physiology, 2015 ABSTRACTOptimal cardiac function depends on proper timing of excitation and contraction in various regions of the heart, as well as on appropriate heart rate. This is accomplished via specialized electrical properties of various components of the system, including the sinoatrial node, atria, atrioventricular node, His‐Purkinje system, and ventricles ...
Bartos, Daniel C +2 more
openaire +4 more sources
Frontiers in Physiology, 2021 Background: Endurance athletes are prone to bradyarrhythmias, which in the long-term may underscore the increased incidence of pacemaker implantation reported in this population.
Isabelle Bidaud +19 more
doaj +1 more source
Exploring the Two Coupled Conformational Changes That Activate the Munc18-1/Syntaxin-1 Complex
Frontiers in Molecular Neuroscience, 2021 Calcium-dependent synaptic vesicle exocytosis is mediated by SNARE complex formation. The transition from the Munc18-1/syntaxin-1 complex to the SNARE complex is catalyzed by the Munc13-1 MUN domain and involves at least two conformational changes ...
Jihong Gong +6 more
doaj +1 more source
Langmuir, 2013 The objective of this historical review is to recall the development of the field of synthetic ion channels over the past three decades. The most inspiring and influential breakthroughs with regard to structure and function are brought together to give the general reader an easily accessible understanding of the field.
Sakai Naomi, Matile Stefan
openaire +5 more sources
Neurobiology of Disease, 2023 SCN1A gain-of-function variants are associated with early onset developmental and epileptic encephalopathies (DEEs) that possess distinct clinical features compared to Dravet syndrome caused by SCN1A loss-of-function.
Géza Berecki +3 more
doaj +1 more source
Annual Review of Biophysics, 2023 Mitochondria are involved in multiple cellular tasks, such as ATP synthesis, metabolism, metabolite and ion transport, regulation of apoptosis, inflammation, signaling, and inheritance of mitochondrial DNA. The majority of the correct functioning of mitochondria is based on the large electrochemical proton gradient, whose component, the inner ...
Szabo I., Szewczyk A.
openaire +2 more sources
Calcium-permeable ion channels in control of autophagy and cancer
Frontiers in Physiology, 2013 Autophagy, or cellular self-eating, is a tightly regulated cellular pathway the main purpose of which is lysosomal degradation and subsequent recycling of cytoplasmic material to maintain normal cellular homeostasis.
Artem eKondratskyi +5 more
doaj +1 more source
PTPRM Is Critical for Synapse Formation Regulated by Zinc Ion
Frontiers in Molecular Neuroscience, 2022 In the nervous system, the trace metal ion zinc is required for normal mammalian brain development and physiology. Zinc homeostasis is essential for the control of physiological and pathophysiological brain functions.
Xiaoqiang Mo +8 more
doaj +1 more source