Results 61 to 70 of about 4,379 (174)

Protein pyrophosphorylation: moving forward [PDF]

, 2016
Genetic ablation of inositol pyrophosphate synthesis has established the fundamental importance of this class of molecules to the eukaryote cell. These studies, however, must be complemented by cell biology and biochemical approaches to appreciate the ...
Saiardi, A
core   +3 more sources

Fluorometric Detection of Inositol Phosphates and the Activity of Their Enzymes with Synthetic Pores:  Discrimination of IP₇ and IP₆ and Phytate Sensing in Complex Matrices

Journal of the American Chemical Society, 2008
We report the fluorometric and noninvasive detection of inositol phosphates, which act as privileged blockers of synthetic pores. Phytate (IP6) and IP7 recognition in the pore occurs substoichiometrically in the low nanomolar range, with more than 2 orders of magnitude higher sensitivity than the best available alternative.
Butterfield, Sara Marie, Tran, Duy-Hien, Zhang, Honglu, Prestwich, Glenn D., Matile, Stefan   +4 more
openaire   +3 more sources

Role of SLC16A10 in Psoriasis Through the Regulation of Arachidonic Acid Metabolism in Keratinocytes

Advanced Science, Volume 12, Issue 39, October 20, 2025.
This study demonstrates that SLC16A10 plays a crucial role in psoriasis pathogenesis through arachidonic acid metabolism regulation in keratinocytes. Using multi‐omics analysis and experimental validation, researchers identify SLC16A10 as both a diagnostic biomarker and therapeutic target.
Jingyuan Yang, Yixuan Chen, Bowei Li, Shuang Wu, Hang Liang, Xingyue Yang, Xiaozhen Li, Ping Sun, Guangjin Guo, Ting Li, Yuying Jia, Haijiao Li, Mengqi Bai, Jie Xu, Zhijie Liu, Wei Liu, Xiangkang Jiang, Hong Cai   +17 more
wiley   +1 more source

The effect of respondent incentives on panel attrition in a sequential mixed-mode design [PDF]

, 2017
This paper evaluates the effect of switching an existing panel study from a unimode face-to-face design to a sequential mixed-mode design (web followed by face-to-face interviewing) on attrition.
Gaia, A.
core  

Emerging tools for the early detection of prostate cancer

BJUI Compass, Volume 6, Issue 9, September 2025.
Abstract Introduction Prostate cancer (PCa) is the second most common cancer in men globally, with a rising incidence. Early detection through population‐based screening by Prostate Specific Antigen (PSA) testing improves survival outcomes, at the expense of overdiagnosis and overtreatment of clinically insignificant disease.
Muhammad Haider, Jeffrey J. Leow, Tobias Nordström, Ashkan Mortezavi, Peter Albers, Rakesh Heer, Prabhakar Rajan   +6 more
wiley   +1 more source

An overview of the mid-infrared spectro-interferometer MATISSE: science, concept, and current status

, 2016
MATISSE is the second-generation mid-infrared spectrograph and imager for the Very Large Telescope Interferometer (VLTI) at Paranal. This new interferometric instrument will allow significant advances by opening new avenues in various fundamental ...
Agocs, T., Allouche, F., Antonelli, P., Augereau, J. -C., Avila, G., Bailet, C., Beckmann, U., Behrend, J., Berger, J. -P., Berio, P., Bettonvil, F., Bourget, P., Brast, R., Bresson, Y., Bristow, P., Clausse, J. -M., Connot, C., Conzelmann, R., Cruzalebes, P., Csepany, G., Danchi, W. C., De Haan, M., Delbo, M., Dominik, C., Duc, T. Phan, Elswijk, E., Fantei, Y., Finger, G., Gabasch, A., Glindemann, A., Gonté, F., Graser, U., Guitton, F., Guniat, S., Haguenauer, P., Hanenburg, H., Heininger, M., Henning, T., Hofferbert, R., Hofmann, K. -H., Hogerheijde, M., Hron, J., Hummel, C., Isderda, J., Ives, D., Jaffe, W., Jakob, G., Jasko, A., Jolley, P., Kiraly, S., Kragt, J., Kroener, T., Kroes, G., Kuindersma, S., Labadie, L., Lagarde, S., Lanz, T., Laun, W., Lehmitz, M., Leinert, C., Lizon, J. -L., Lopez, B., Lucuix, C., Marcotto, A., Martinache, F., Martinot-Lagarde, G., Matter, A., Mauclert, N., Mehrgan, L., Meilland, A., Meisenheimer, K., Mellein, M., Menardi, S., Merand, A., Millour, F., Morel, S., Neumann, U., Nussbaum, E., Ottogalli, S., Palsa, R., Panduro, J., Pantin, E., Percheron, I., Petrov, R. G., Pott, J. -U., Pozna, E., Robbe-Dubois, S., Roelfsema, R., Rupprecht, G., Schertl, D., Schmidt, C., Schoeller, M., Schuil, M., Spang, A., stegmeier, J., ter Horst, R., Tromp, N., Vakili, F., Van Belle, G., van Boekel, R., van Duin, A., Vannier, M., Venema, L., Wagner, K., Weigelt, G., Woillez, J., Wolf, S.   +106 more
core   +2 more sources

Protein kinase- and lipase inhibitors of inositide metabolism deplete IP7 indirectly in pancreatic β-cells: Off-target effects on cellular bioenergetics and direct effects on IP6K activity

Cellular Signalling, 2018
Inositol pyrophosphates have emerged as important regulators of many critical cellular processes from vesicle trafficking and cytoskeletal rearrangement to telomere length regulation and apoptosis. We have previously demonstrated that 5-di-phosphoinositol pentakisphosphate, IP7, is at a high level in pancreatic β-cells and is important for insulin ...
Subu Surendran Rajasekaran, Christopher Illies, Stephen B. Shears, Huanchen Wang, Thais S. Ayala, Joilson O. Martins, Elisabetta Daré, Per-Olof Berggren, Christopher J. Barker   +8 more
openaire   +2 more sources

Emerging roles of inositol pyrophosphates as key modulators of fungal pathogenicity

Virulence, 2018
Inositol pyrophosphates (PP-IPs) are energy-rich small molecules that are omnipresent in eukaryotic cells, from yeast to mammals, playing central roles in overall cellular homeostasis as a diverse and multifaceted class of intracellular messengers ...
Hyun Ah Kang
doaj   +1 more source

Inositol Polyphosphate Kinases, Fungal Virulence and Drug Discovery

Journal of Fungi, 2016
Opportunistic fungi are a major cause of morbidity and mortality world-wide, particularly in immunocompromised individuals. Developing new treatments to combat invasive fungal disease is challenging given that fungal and mammalian host cells are ...
Cecilia Li, Sophie Lev, Adolfo Saiardi, Desmarini Desmarini, Tania C. Sorrell, Julianne T. Djordjevic   +5 more
doaj   +1 more source

Analysis of Dictyostelium discoideum Inositol Pyrophosphate Metabolism by Gel Electrophoresis. [PDF]

, 2014
The social amoeba Dictyostelium discoideum was instrumental in the discovery and early characterization of inositol pyrophosphates, a class of molecules possessing highly-energetic pyrophosphate bonds.
Chubb, JR, Gaspari, M, Livermore, T, Pisani, F, Rose, G, Saiardi, A   +5 more
core