Results 41 to 50 of about 4,379 (174)

Deletion of IP6K1 in mice accelerates tumor growth by dysregulating the tumor-immune microenvironment

open access: yesAnimal Cells and Systems, 2022
A family of inositol hexakisphosphate kinases (IP6Ks) catalyzes the production of inositol pyrophosphate IP7 (5-diphosphoinositolpentakisphosphate) which is known to modulate various biological events such as cell growth. While targeting IP6K1 in various
Haein Lee   +4 more
doaj   +1 more source

Inositol hexakisphosphate kinases differentially regulate trafficking of vesicular glutamate transporters 1 and 2

open access: yesFrontiers in Cellular Neuroscience, 2022
Inositol pyrophosphates have been implicated in cellular signaling and membrane trafficking, including synaptic vesicle (SV) recycling. Inositol hexakisphosphate kinases (IP6Ks) and their product, diphosphoinositol pentakisphosphate (PP-IP5 or IP7 ...
Haiyan Li   +3 more
doaj   +1 more source

HST/FOS Eclipse mapping of IP Pegasi in outburst

open access: yes, 2004
We report the results of a time-resolved eclipse mapping of the dwarf nova IP Pegasi during the decline of its May 1993 outburst from HST/FOS fast spectroscopy covering 3 eclipses in the ultraviolet spectral range.Comment: 1 page 0 ...
Baptista, R., Horne, K., Saito, R. K.
core   +2 more sources

Interaction of calcium responsive proteins and transcriptional factors with the PHO regulon in yeasts and fungi

open access: yesFrontiers in Cell and Developmental Biology, 2023
Phosphate and calcium ions are nutrients that play key roles in growth, differentiation and the production of bioactive secondary metabolites in filamentous fungi. Phosphate concentration regulates the biosynthesis of hundreds of fungal metabolites.
Juan F. Martín
doaj   +1 more source

Decreasing the LHC impedance with a nonlinear collimation system [PDF]

open access: yes, 2007
A two-stage nonlinear collimation system based on a pair of skew sextupoles is presented for the LHC.We show the details of the optics design and study the halo cleaning efficiency of such a system.
Faus-Golfe, A   +2 more
core   +1 more source

HST/FOS Time-resolved spectral mapping of IP Pegasi at the end of an outburst

open access: yes, 2005
We report an eclipse mapping analysis of time-resolved ultraviolet spectroscopy covering three eclipses of the dwarf nova IP Pegasi on the late decline of the 1993 May outburst.
Baptista   +30 more
core   +1 more source

Inflammation and Cancer: Molecular Mechanisms and Therapeutic Targets

open access: yesMedComm, Volume 7, Issue 2, February 2026.
Chronic inflammation fuels tumorigenesis via “internal drivers” and “external attractions.” Targeting these core mechanisms with combined therapies/novel deliveries enables precise, potent anti‐inflammatory–antitumor treatment. ABSTRACT Inflammation is a core pathological factor regulating tumor initiation, progression, and therapeutic resistance, and ...
Xiaodie Liu   +4 more
wiley   +1 more source

Are Inositol Polyphosphates the Missing Link in Dynamic Cullin RING Ligase Regulation by the COP9 Signalosome?

open access: yesBiomolecules, 2019
The E3 ligase activity of Cullin RING Ligases (CRLs) is controlled by cycles of neddylation/deneddylation and intimately regulated by the deneddylase COP9 Signalosome (CSN), one of the proteasome lid-CSN-initiation factor 3 (PCI) domain-containing “
Xiaozhe Zhang, Feng Rao
doaj   +1 more source

Combining immunotherapy with high-dose radiation therapy (HDRT) significantly inhibits tumor growth in a syngeneic mouse model of high-risk neuroblastoma

open access: yesHeliyon, 2023
Purpose: The mortality in patients with MYCN-amplified high-risk neuroblastoma remains greater than 50% despite advances in multimodal therapy.
Shuobo Boboila   +13 more
doaj   +1 more source

Beam-beam-induced orbit effects at LHC

open access: yes, 2014
For high bunch intensities the long-range beam-beam interactions are strong enough to provoke effects on the orbit. As a consequence the closed orbit changes.
Fernandez, R. Alemany, Schaumann, M.
core   +1 more source

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