Results 51 to 60 of about 947 (141)

Regulation of Hematopoietic Cell Development and Function Through Phosphoinositides

Frontiers in Immunology, 2018
One of the most paramount receptor-induced signal transduction mechanisms in hematopoietic cells is production of the lipid second messenger phosphatidylinositol(3,4,5)trisphosphate (PIP3) by class I phosphoinositide 3 kinases (PI3K).
Mila Elich, Karsten Sauer, Karsten Sauer
doaj   +1 more source

Understanding the Limited Uptake of Reprocessed Construction Materials: A Pro‐Environmental Behaviour Perspective

Sustainable Development, Volume 33, Issue 4, Page 5134-5150, August 2025.
ABSTRACT Reverse logistics (RL) aims to direct demolition waste (DW) away from landfills towards alternative uses by converting it into reprocessed construction materials (RCMs). However, recent studies indicate that the uptake of RCMs remains limited, adversely affecting the effectiveness of RL for DW. Therefore, developing markets for these materials
Gihan Anuradha Tennakoon, Raufdeen Rameezdeen, Nicholas Chileshe   +2 more
wiley   +1 more source

Genetic suppressor screen identifies Tgp1 (glycerophosphocholine transporter), Kcs1 (IP6 kinase), and Plc1 (phospholipase C) as determinants of inositol pyrophosphate toxicosis in fission yeast

mBio
The inositol pyrophosphate signaling molecule 1,5-IP8 is an agonist of RNA 3'-processing and transcription termination in fission yeast that regulates the expression of phosphate acquisition genes pho1, pho84, and tgp1.
Lauren Bednor, Ana M. Sanchez, Angad Garg, Stewart Shuman, Beate Schwer   +4 more
doaj   +1 more source

Molecular modeling, dynamics simulation and characterization of human inositol hexakisphosphate kinase 1 (IP6K1) related to diabetes

Journal of Applied Sciences and Environmental Management, 2019
Inositol hexakisphosphate kinase-1 (IP6K1) protein plays an important role in insulin signaling producing IP7 that inhibit the action of protein kinase B (Akt).
O.O. Elekofehinti, Y.V. Aladenika, Y.R. Alli-Smith, O.C. Ejelonu, A.O. Lawal   +4 more
doaj   +1 more source

Ultimate Bearing Capacity of Pile Caps Comprising Concrete‐Filled Dual Steel Tubes

JAPAN ARCHITECTURAL REVIEW, Volume 8, Issue 1, January–December 2025.
ABSTRACT The construction of building foundations requires substantial time and effort, particularly in fabricating reinforced concrete footings and foundation beams. To address these challenges, this paper proposes a novel structural system that utilizes steel structures for the foundation beams and reinforces pile heads with double steel tubes ...
Hiroshi Mashiko, Atsushi Suzuki, Qing Zhang, Yoshihiro Kimura   +3 more
wiley   +1 more source

Protein kinase- and lipase inhibitors of inositide metabolism deplete IP7 indirectly in pancreatic β-cells: Off-target effects on cellular bioenergetics and direct effects on IP6K activity

Cellular Signalling, 2018
Inositol pyrophosphates have emerged as important regulators of many critical cellular processes from vesicle trafficking and cytoskeletal rearrangement to telomere length regulation and apoptosis. We have previously demonstrated that 5-di-phosphoinositol pentakisphosphate, IP7, is at a high level in pancreatic β-cells and is important for insulin ...
Subu Surendran Rajasekaran, Christopher Illies, Stephen B. Shears, Huanchen Wang, Thais S. Ayala, Joilson O. Martins, Elisabetta Daré, Per-Olof Berggren, Christopher J. Barker   +8 more
openaire   +2 more sources

TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway

Molecular Metabolism, 2016
Objective: Obesity and type 2 diabetes (T2D) lead to various life-threatening diseases such as coronary heart disease, stroke, osteoarthritis, asthma, and neurodegeneration.
Sarbani Ghoshal, Qingzhang Zhu, Alice Asteian, Hua Lin, Haifei Xu, Glen Ernst, James C. Barrow, Baoji Xu, Michael D. Cameron, Theodore M. Kamenecka, Anutosh Chakraborty   +10 more
doaj   +1 more source

Corporate sustainability strategy deployment: A case study on the implementation of corporate sustainability using hoshin kanri

Corporate Social Responsibility and Environmental Management, Volume 32, Issue 1, Page 927-946, January 2025.
Abstract Companies face difficulties when attempting to implement corporate sustainability (CS), especially linking operational activities to their overall sustainability strategy remains a main challenge. The present study applies a single‐case study approach to contribute to literature on CS implementation and to provide a framework for the ...
Katharina E. Roche, Rupert J. Baumgartner   +1 more
wiley   +1 more source

“A Circle of Positivity”: Adolescents' Perspectives on Meaningful Leisure Time and Good Health in Relation to School Performance

International Journal of Consumer Studies, Volume 48, Issue 5, September 2024.
ABSTRACT In Sweden, approximately a quarter of upper secondary school students leave school early or do not complete their studies with full grades. Structured leisure time activities have been associated with improved health, enhanced school performance, and future college attendance.
Christine Persson Osowski, Camilla Eriksson, Sara Karvonen, Katarina Bälter   +3 more
wiley   +1 more source

Adolescent and young adult lymphoma: collaborative efforts toward optimizing care and improving outcomes

Blood Advances, 2017
: Lymphomas are responsible for approximately 20% to 25% of annual cancer diagnoses in the adolescent and young adult (AYA) population. In 2006, the National Cancer Institute and the Lance Armstrong Foundation developed a joint Adolescent and Young Adult
Justine M. Kahn, Nmazuo W. Ozuah, Kieron Dunleavy, Tara O. Henderson, Kara Kelly, Ann LaCasce   +5 more
doaj   +1 more source