Results 31 to 40 of about 947 (141)

Deletion of IP6K1 in mice accelerates tumor growth by dysregulating the tumor-immune microenvironment

Animal Cells and Systems, 2022
A family of inositol hexakisphosphate kinases (IP6Ks) catalyzes the production of inositol pyrophosphate IP7 (5-diphosphoinositolpentakisphosphate) which is known to modulate various biological events such as cell growth. While targeting IP6K1 in various
Haein Lee, Seung Ju Park, Sehoon Hong, Seol-Wa Lim, Seyun Kim   +4 more
doaj   +1 more source

Inositol pyrophosphate profiling reveals regulatory roles of IP6K2-dependent enhanced IP ₇ metabolism in enteric nervous system

Journal of Biological Chemistry, 2022
Abstract Inositol pyrophosphates (PP-IPs) regulate diverse physiological processes; to better understand their functional roles, assessing their tissue-specific distribution is important. Here, we profiled PP-IP levels in mammalian organs using a novel HILIC-MS/MS protocol and discovered that the gastrointestinal ...
Ito M, Fujii N, Kohara S, Hori S, Tanaka M, Wittwer C, Kikuchi K, Iijima T, Kakimoto Y, Hirabayashi K, Kurotaki D, Jessen HJ, Saiardi A, Nagata E.   +13 more
europepmc   +5 more sources

Inositol hexakisphosphate kinases differentially regulate trafficking of vesicular glutamate transporters 1 and 2

Frontiers in Cellular Neuroscience, 2022
Inositol pyrophosphates have been implicated in cellular signaling and membrane trafficking, including synaptic vesicle (SV) recycling. Inositol hexakisphosphate kinases (IP6Ks) and their product, diphosphoinositol pentakisphosphate (PP-IP5 or IP7 ...
Haiyan Li, Maia Datunashvili, Reno C. Reyes, Susan M. Voglmaier   +3 more
doaj   +1 more source

Interaction of calcium responsive proteins and transcriptional factors with the PHO regulon in yeasts and fungi

Frontiers in Cell and Developmental Biology, 2023
Phosphate and calcium ions are nutrients that play key roles in growth, differentiation and the production of bioactive secondary metabolites in filamentous fungi. Phosphate concentration regulates the biosynthesis of hundreds of fungal metabolites.
Juan F. Martín
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

SDG Forward Faster in the Face of Geopolitical and Climate Risks: Does CEO Power Strengthen This Relationship?

Business Strategy and the Environment, EarlyView.
ABSTRACT In a macroeconomic environment characterised by systemic disruptions and global uncertainty, companies are forced to reconfigure their sustainability strategies. This study examines the combined impact of geopolitical and climate risks on corporate commitment to and actual progress toward the United Nations (UN) Sustainable Development Goals ...
Isabel‐María García‐Sánchez
wiley   +1 more source

Combining immunotherapy with high-dose radiation therapy (HDRT) significantly inhibits tumor growth in a syngeneic mouse model of high-risk neuroblastoma

Heliyon, 2023
Purpose: The mortality in patients with MYCN-amplified high-risk neuroblastoma remains greater than 50% despite advances in multimodal therapy.
Shuobo Boboila, Shunpei Okochi, Debarshi Banerjee, Sunjay Barton, Cherease Street, Ariela L. Zenilman, Qi Wang, Robyn D. Gartrell, Yvonne M. Saenger, David Welch, Cheng-Chia Wu, Angela Kadenhe-Chiweshe, Darrell J. Yamashiro, Eileen P. Connolly   +13 more
doaj   +1 more source

Climate change and the antinutrient–antioxidant puzzle in common bean seeds

Journal of the Science of Food and Agriculture, Volume 106, Issue 3, Page 1451-1456, February 2026.
Abstract Non‐proteinaceous and proteinaceous antinutrients in common bean (Phaseolus vulgaris L.) seeds can negatively affect human nutrition by reducing mineral bioavailability and impairing protein digestibility during digestion, respectively. However, many of these compounds also possess strong antioxidant properties that can help protect the plant ...
Juan Vorster, Eleonora Cominelli, Francesca Sparvoli, Alessia Losa, Tea Sala, Karl Kunert   +5 more
wiley   +1 more source

Are Inositol Polyphosphates the Missing Link in Dynamic Cullin RING Ligase Regulation by the COP9 Signalosome?

Biomolecules, 2019
The E3 ligase activity of Cullin RING Ligases (CRLs) is controlled by cycles of neddylation/deneddylation and intimately regulated by the deneddylase COP9 Signalosome (CSN), one of the proteasome lid-CSN-initiation factor 3 (PCI) domain-containing “
Xiaozhe Zhang, Feng Rao
doaj   +1 more source

Inflammation and Cancer: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Chronic inflammation fuels tumorigenesis via “internal drivers” and “external attractions.” Targeting these core mechanisms with combined therapies/novel deliveries enables precise, potent anti‐inflammatory–antitumor treatment. ABSTRACT Inflammation is a core pathological factor regulating tumor initiation, progression, and therapeutic resistance, and ...
Xiaodie Liu, Ziyuan Wang, Huirong Zhu, Yicun Han, Qing Ji   +4 more
wiley   +1 more source