Results 31 to 40 of about 4,379 (174)

Inositol Pyrophosphates: Signaling Molecules with Pleiotropic Actions in Mammals

Molecules, 2020
Inositol pyrophosphates (PP-IPs) such as 5-diphosphoinositol pentakisphosphate (5-IP7) are inositol metabolites containing high-energy phosphoanhydride bonds.
Seulgi Lee, Min-Gyu Kim, Hyoungjoon Ahn, Seyun Kim   +3 more
doaj   +1 more source

A Scalable Synthesis of the IP₇ Isomer, 5-PP-Ins(1,2,3,4,6)P₅ [PDF]

Organic Letters, 2009
The phosphorylated inositol diphosphates, including the diphosphoinositol pentakisphosphate regioisomers, play critical roles in signal transduction and cellular regulation. In particular, the IP(7) isomer 5-PP-Ins(1,2,3,4,6)P(5) is implicated in a nonenzymatic phosphate transfer converting a protein serine phosphate residue to a serine diphosphate.
Honglu, Zhang, James, Thompson, Glenn D, Prestwich   +2 more
openaire   +2 more sources

Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon response.

PLoS Pathogens, 2014
The pattern recognition receptor RIG-I is critical for Type-I interferon production. However, the global regulation of RIG-I signaling is only partially understood. Using a human genome-wide RNAi-screen, we identified 226 novel regulatory proteins of RIG-
Niyas Kudukkil Pulloor, Sajith Nair, Kathleen McCaffrey, Aleksandar D Kostic, Pradeep Bist, Jeremy D Weaver, Andrew M Riley, Richa Tyagi, Pradeep D Uchil, John D York, Solomon H Snyder, Adolfo García-Sastre, Barry V L Potter, Rongtuan Lin, Stephen B Shears, Ramnik J Xavier, Manoj N Krishnan   +16 more
doaj   +1 more source

Three new species of Helicopsyche (Trichoptera, Helicopsychidae) from northern Vietnam, with a key to Helicopsyche species of Vietnam [PDF]

, 2012
Three new species of Helicopsyche Siebold, 1856 are described from Vietnam: Helicopsyche melina sp. nov., Helicopsyche meander sp. nov., and Helicopsyche lamnata sp. nov.
Johanson, Kjell A., Pham, Hong-Thai
core   +3 more sources

Interaction with IP6K1 supports pyrophosphorylation of substrate proteins by the inositol pyrophosphate 5-IP7

Bioscience Reports, 2023
AbstractInositol pyrophosphates (PP-IPs) are a sub-family of water soluble inositol phosphates that possess one or more diphosphate groups. PP-IPs can transfer their β-phosphate group to a phosphorylated Ser residue to generate pyrophosphorylated Ser. This unique post-translational modification occurs on Ser residues that lie in acidic stretches within
Aisha Hamid, Jayashree S. Ladke, Akruti Shah, Monisita Pal, Shubhra Ganguli, Arpita Singh, Rashna Bhandari   +6 more
openaire   +2 more sources

Sphingolipids and Inositol Phosphates Regulate the Tau Protein Phosphorylation Status in Humanized Yeast

Frontiers in Cell and Developmental Biology, 2020
Hyperphosphorylation of protein tau is a hallmark of Alzheimer’s disease (AD). Changes in energy and lipid metabolism have been correlated with the late onset of this neurological disorder.
Francisca Randez-Gil, Lino Bojunga, Francisco Estruch, Joris Winderickx, Maurizio Del Poeta, Maurizio Del Poeta, Jose A. Prieto   +6 more
doaj   +1 more source

The Effect of Online and Mixed-Mode Measurement of Cognitive Ability [PDF]

, 2017
A number of studies, particularly longitudinal surveys, are collecting direct measures of cognitive ability, given its importance as a measure in social science research.
Banks J., Börsch-Supan A., Conway A. R. A., Crimmins E. M., de Leeuw E. D., Denny K., Fischer A., Fisher G. G., Fricker S., Heckman J. J., Herzog A. R., Herzog A. R., Jäckle A., Jäckle A., Knies G., Kuh D., Lang F., McFall S., Nyborg H., Ofstedal M. B., Petchev A., Power C., Richardson J. T., Schwarz N., Summerfield M., Tarek Al Baghal, Tourangeau R., Wagner G. G., Wooden M., Yan T.   +29 more
core   +1 more source

Mutations in Diphosphoinositol-Pentakisphosphate Kinase PPIP5K2 are associated with hearing loss in human and mouse. [PDF]

PLoS Genetics, 2018
Autosomal recessive nonsyndromic hearing loss is a genetically heterogeneous disorder. Here, we report a severe-to-profound sensorineural hearing loss locus, DFNB100 on chromosome 5q13.2-q23.2.
Rizwan Yousaf, Chunfang Gu, Zubair M Ahmed, Shaheen N Khan, Thomas B Friedman, Sheikh Riazuddin, Stephen B Shears, Saima Riazuddin   +7 more
doaj   +1 more source

General solution of equations of motion for a classical particle in 9-dimensional Finslerian space

, 2010
A Lagrangian description of a classical particle in a 9-dimensional flat Finslerian space with a cubic metric function is constructed. The general solution of equations of motion for such a particle is obtained.
A. V. Solovýov, A. V. Solov’ev, D. Finkelstein, L. D. Landau, L. S. Pontryagin   +4 more
core   +1 more source

IP7 - Application of Adaptive Neurofuzzy Inference System for calculation of heat power consumption using infrared thermography

Proceedings OPTO 2009 & IRS² 2009, 2009
1. Introdu ction In this paper a new method for calculation of heat power consumption in a heat exchanger is described. The method is based on the analysis of phenomena occurri ng on the ambient side. The calculation of heat power consumption represents an inverse heat transfer problem [1, 2]. In [3] an artificial neural network was used to approximate
Sebastian Dudzik, Waldemar Minkina
openaire   +2 more sources