Fungal Inositol Pyrophosphate IP7 Is Crucial for Metabolic Adaptation to the Host Environment and Pathogenicity [PDF]
mBio, 2015 Inositol pyrophosphates (PP-IPs) comprising inositol, phosphate, and pyrophosphate (PP) are essential for multiple functions in eukaryotes. Their role in fungal pathogens has never been addressed.
Sophie Lev +8 more
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Activities and Structure-Function Analysis of Fission Yeast Inositol Pyrophosphate (IPP) Kinase-Pyrophosphatase Asp1 and Its Impact on Regulation of pho1 Gene Expression [PDF]
mBio, 2022 Inositol pyrophosphates (IPPs) are signaling molecules that regulate cellular phosphate homeostasis in diverse eukaryal taxa. In fission yeast, mutations that increase 1,5-IP8 derepress the PHO regulon while mutations that ablate IP8 synthesis are PHO ...
Bradley Benjamin +5 more
doaj +2 more sources
Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes [PDF]
Diabetes, Metabolic Syndrome and Obesity, 2014 Richard WA Mackenzie, Bradley T Elliott Department of Human and Health Sciences, Facility of Science and Technology, University of Westminster, London, UK Abstract: Type 2 diabetes is a metabolic disease categorized primarily by reduced insulin ...
Mackenzie RWA, Elliott BT
doaj +6 more sources
The long-awaited demonstration of protein pyrophosphorylation by IP7 in vivo? [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2010 > Being wanted, he may be more wonder’d at… . > > William Shakespeare, Henry IV , Part 1 The “high-energy” of inositol pyrophosphates such as IP7 has long been considered as their raison d’etre (see ref. 1). Unsurprisingly, therefore, the excitement was palpable when these pyrophosphates were shown to transphosphorylate proteins in vitro (1).
exaly +2 more sources
Targeting the Inositol Pyrophosphate Biosynthetic Enzymes in Metabolic Diseases
Molecules, 2020 In mammals, a family of three inositol hexakisphosphate kinases (IP6Ks) synthesizes the inositol pyrophosphate 5-IP7 from IP6. Genetic deletion of Ip6k1 protects mice from high fat diet induced obesity, insulin resistance and fatty liver. IP6K1 generated
Sandip Mukherjee, Anutosh Chakraborty
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Isoniazid-Derived Hydrazones Featuring Piperazine/Piperidine Rings: Design, Synthesis, and Investigation of Antitubercular Activity [PDF]
BiomoleculesIsoniazid (isonicotinic acid hydrazide, INH) is a key drug used to treat tuberculosis (TB), which continues to be the world’s most lethal infectious disease.
Esma Özcan +7 more
doaj +2 more sources
A systematic genetic screen for genes involved in sensing inorganic phosphate availability in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2017 Saccharomyces cerevisiae responds to changes in extracellular inorganic phosphate (Pi) availability by regulating the activity of the phosphate-responsive (PHO) signaling pathway, enabling cells to maintain intracellular levels of the essential nutrient ...
Joonhyuk Choi +4 more
doaj +6 more sources
Journal of Biological Chemistry, 2022 AbstractInositol pyrophosphates (PP-IPs) regulate diverse physiological processes; to better understand their functional roles, assessing their tissue-specific distribution is important. Here, we profiled PP-IP levels in mammalian organs using a novel HILIC-MS/MS protocol and discovered that the gastrointestinal tract (GIT) contained the highest levels
Ito M +13 more
europepmc +5 more sources
Arg1 from Cryptococcus neoformans lacks PI3 kinase activity and conveys virulence roles via its IP3-4 kinase activity [PDF]
mBioInositol tris/tetrakis phosphate kinases (IP3-4K) in the human fungal priority pathogens, Cryptococcus neoformans (CnArg1) and Candida albicans (CaIpk2), convey numerous virulence functions, yet it is not known whether the IP3-4K catalytic activity or a ...
Desmarini Desmarini +6 more
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CHIMIA, 2008 Recent experimental evidence confirms synthetic pores as operational multicomponent sensors in complex matrices. This work in practice is summarized, with emphasis on topics of current concern which exemplify the use of enzymes as signal ...
Sara M. Butterfield, Stefan Matile
doaj +4 more sources