Results 21 to 30 of about 947 (141)
Stem Cell Research & Therapy, 2019 Objective To investigate the potential effect of IP7 on the autophagy and apoptosis of bone marrow mesenchymal stem cells (BM-MSCs) caused by hypoxia. Methods BM-MSCs isolated from adult male C57BL/6 mice were exposed to normoxic condition and hypoxic ...
Jingyu Deng +9 more
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TNP and its analogs: Modulation of IP6K and CYP3A4 inhibition
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 Inositol hexakisphosphate kinase (IP6K) is an important mammalian enzyme involved in various biological processes such as insulin signalling and blood clotting.
Seulgi Lee +14 more
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Targeting the Inositol Pyrophosphate Biosynthetic Enzymes in Metabolic Diseases
Molecules, 2020 In mammals, a family of three inositol hexakisphosphate kinases (IP6Ks) synthesizes the inositol pyrophosphate 5-IP7 from IP6. Genetic deletion of Ip6k1 protects mice from high fat diet induced obesity, insulin resistance and fatty liver. IP6K1 generated
Sandip Mukherjee +2 more
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Inositol Pyrophosphates: Signaling Molecules with Pleiotropic Actions in Mammals
Molecules, 2020 Inositol pyrophosphates (PP-IPs) such as 5-diphosphoinositol pentakisphosphate (5-IP7) are inositol metabolites containing high-energy phosphoanhydride bonds.
Seulgi Lee +3 more
doaj +1 more source
PLoS Pathogens, 2014 The pattern recognition receptor RIG-I is critical for Type-I interferon production. However, the global regulation of RIG-I signaling is only partially understood. Using a human genome-wide RNAi-screen, we identified 226 novel regulatory proteins of RIG-
Niyas Kudukkil Pulloor +16 more
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Frontiers in Cell and Developmental Biology, 2020 Hyperphosphorylation of protein tau is a hallmark of Alzheimer’s disease (AD). Changes in energy and lipid metabolism have been correlated with the late onset of this neurological disorder.
Francisca Randez-Gil +6 more
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Bioscience Reports, 2023 Abstract Inositol pyrophosphates (PP-IPs) are a sub-family of water soluble inositol phosphates that possess one or more diphosphate groups. PP-IPs can transfer their β-phosphate group to a phosphorylated Ser residue to generate pyrophosphorylated Ser. This unique post-translational modification occurs on Ser residues
Aisha Hamid +6 more
openaire +2 more sources
A Scalable Synthesis of the IP7 Isomer, 5-PP-Ins(1,2,3,4,6)P5 [PDF]
Organic Letters, 2009 The phosphorylated inositol diphosphates, including the diphosphoinositol pentakisphosphate regioisomers, play critical roles in signal transduction and cellular regulation. In particular, the IP(7) isomer 5-PP-Ins(1,2,3,4,6)P(5) is implicated in a nonenzymatic phosphate transfer converting a protein serine phosphate residue to a serine diphosphate.
Honglu, Zhang +2 more
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A systematic genetic screen for genes involved in sensing inorganic phosphate availability in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2017 Saccharomyces cerevisiae responds to changes in extracellular inorganic phosphate (Pi) availability by regulating the activity of the phosphate-responsive (PHO) signaling pathway, enabling cells to maintain intracellular levels of the essential nutrient ...
Joonhyuk Choi +4 more
doaj +1 more source
Mutations in Diphosphoinositol-Pentakisphosphate Kinase PPIP5K2 are associated with hearing loss in human and mouse. [PDF]
PLoS Genetics, 2018 Autosomal recessive nonsyndromic hearing loss is a genetically heterogeneous disorder. Here, we report a severe-to-profound sensorineural hearing loss locus, DFNB100 on chromosome 5q13.2-q23.2.
Rizwan Yousaf +7 more
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