Results 21 to 30 of about 4,379 (174)

Genetic suppressor screen identifies Tgp1 (glycerophosphocholine transporter), Kcs1 (IP6 kinase), and Plc1 (phospholipase C) as determinants of inositol pyrophosphate toxicosis in fission yeast [PDF]

mBio
The inositol pyrophosphate signaling molecule 1,5-IP8 is an agonist of RNA 3'-processing and transcription termination in fission yeast that regulates the expression of phosphate acquisition genes pho1, pho84, and tgp1.
Lauren Bednor, Ana M. Sanchez, Angad Garg, Stewart Shuman, Beate Schwer   +4 more
doaj   +2 more sources

Robotic-Assisted Capture-Systematic Evolution of Ligands by Exponential Enrichment of RNA Aptamers Binding to Small Molecules. [PDF]

Chembiochem
This study demonstrates the rapid selection of RNA aptamers that can target various small molecules through a newly established automated capture‐systematic evolution of ligands by exponential enrichment technique. Throughout the study, this method is applied to aptamer selection for several small molecules, resulting in aptamers that bind with high ...
Legen T, Mayer G.
europepmc   +2 more sources

A novel method for the purification of inositol phosphates from biological samples reveals that no phytate is present in human plasma or urine [PDF]

Open Biology, 2015
Inositol phosphates are a large and diverse family of signalling molecules. While genetic studies have discovered important functions for them, the biochemistry behind these roles is often not fully characterized.
Miranda S. C. Wilson, Simon J. Bulley, Francesca Pisani, Robin F. Irvine, Adolfo Saiardi   +4 more
doaj   +1 more source

5-Diphosphoinositol pentakisphosphate (5-IP7) regulates phosphate release from acidocalcisomes and yeast vacuoles [PDF]

Journal of Biological Chemistry, 2018
Acidocalcisomes of Trypanosoma brucei and the acidocalcisome-like vacuoles of Saccharomyces cerevisiae are acidic calcium compartments that store polyphosphate (polyP). Both organelles possess a phosphate-sodium symporter (TbPho91 and Pho91p in T. brucei and yeast, respectively), but the roles of these transporters in growth and orthophosphate (Pi ...
Evgeniy Potapenko, Ciro D. Cordeiro, Guozhong Huang, Melissa Storey, Christopher Wittwer, Amit K. Dutta, Henning J. Jessen, Vincent J. Starai, Roberto Docampo   +8 more
openaire   +3 more sources

Inositol Pyrophosphate Metabolism Regulates Presynaptic Vesicle Cycling at Central Synapses

iScience, 2020
Summary: The coordination of synaptic vesicle exocytosis and endocytosis supports neurotransmitter release from presynaptic terminals. Although inositol pyrophosphates, such as 5-diphosphoinositol pentakisphosphate (5-IP7), are versatile signaling ...
Seung Ju Park, Hoyong Park, Min-Gyu Kim, Seungjae Zhang, Seung Eun Park, Seyun Kim, ChiHye Chung   +6 more
doaj   +1 more source

Nutrient-regulated antisense and intragenic RNAs modulate a signal transduction pathway in yeast. [PDF]

PLoS Biology, 2008
The budding yeast Saccharomyces cerevisiae alters its gene expression profile in response to a change in nutrient availability. The PHO system is a well-studied case in the transcriptional regulation responding to nutritional changes in which a set of ...
Masafumi Nishizawa, Tae Komai, Yuki Katou, Katsuhiko Shirahige, Takehiko Ito, Akio Toh-E   +5 more
doaj   +1 more source

Inositol pyrophosphates mediated the apoptosis induced by hypoxic injury in bone marrow-derived mesenchymal stem cells by autophagy

Stem Cell Research & Therapy, 2019
Objective To investigate the potential effect of IP7 on the autophagy and apoptosis of bone marrow mesenchymal stem cells (BM-MSCs) caused by hypoxia. Methods BM-MSCs isolated from adult male C57BL/6 mice were exposed to normoxic condition and hypoxic ...
Jingyu Deng, Chao Yang, Yong Wang, Ming Yang, Haixu Chen, Hongjuan Ning, Chengzhu Wang, Yanjun Liu, Zheng Zhang, Taohong Hu   +9 more
doaj   +1 more source

Synthesis and biological evaluation of flavonoid-based IP6K2 inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Inositol polyphosphates (IPs) are a group of inositol metabolites that act as secondary messengers for external signalling cues. They play various physiological roles such as insulin release, telomere length maintenance, cell metabolism, and aging ...
Myunghwan Ahn, Seung Eun Park, Jiyeon Choi, Jiahn Choi, Doyoung Choi, Dongju An, Hayoung Jeon, Soowhan Oh, Kiho Lee, Jaehoon Kim, Jaebong Jang, Seyun Kim, Youngjoo Byun   +12 more
doaj   +1 more source

TNP and its analogs: Modulation of IP6K and CYP3A4 inhibition

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Inositol hexakisphosphate kinase (IP6K) is an important mammalian enzyme involved in various biological processes such as insulin signalling and blood clotting.
Seulgi Lee, Bernie Byeonghoon Park, Hongmok Kwon, Vitchan Kim, Jang Su Jeon, Rowoon Lee, Milan Subedi, Taehyeong Lim, Hyunsoo Ha, Dongju An, Jaehoon Kim, Donghak Kim, Sang Kyum Kim, Seyun Kim, Youngjoo Byun   +14 more
doaj   +1 more source

Inositols in Insulin Signaling and Glucose Metabolism [PDF]

, 2018
In the past decades, both the importance of inositol for human health and the complex interaction between glucose and inositol have been the subject of increasing consideration. Glucose has been shown to interfere with cellular transmembrane transport of
Bevilacqua, Arturo, Bizzarri, Mariano
core   +1 more source