Results 11 to 20 of about 4,447 (126)

Immunological Interactions Between Gammadelta T Cells and West Nile Virus in the Infected Host. [PDF]

Rev Med Virol
ABSTRACT Between mosquitoes and birds, West Nile virus (WNV) is a neurotropic flavivirus, an arthropod‐borne pathogen involved in an enzootic cycle. Additionally, it can infect both people and horses, leading to severe illness. Since 1999, WNV has spread across North and South America, including Mexico and the Caribbean.
Cimini E, Tartaglia E, Cristofanelli F, Gili S, Maggi F.   +4 more
europepmc   +2 more sources

Genome-scale Metabolic Modeling Guided Escherichia coli Engineering for De Novo Biosynthesis of Chrysanthemic Acid. [PDF]

Adv Sci (Weinh)
Genome‐scale metabolic modeling is preceded to the engineered E. coli cell factory for the de novo biosynthesis of biopesticide chrysanthemic acid. The debranching strategy redirects metabolic flux, enhancing precursor and target compound production.
Yu J, Cheng K, Qu S, Wang J, Wang X, Zhao C, Li W.   +6 more
europepmc   +2 more sources

Balancing Cell Growth and Product Synthesis for Efficient Microbial Cell Factories. [PDF]

Adv Sci (Weinh)
This review presents state‐of‐the‐art metabolic engineering strategies to balance microbial cell growth and product synthesis in biorefineries. It surveys pathway engineering, dynamic genetic circuits, orthogonal control systems, synthetic microbial consortia, and fermentation optimization, alongside integrative modeling approaches.
Liu L, Ding D, Wang H, Ren X, Lee SY, Zhang D.   +5 more
europepmc   +2 more sources

Gut Microbial Variations Associated With Proton Pump Inhibitor Use in the Boston Puerto Rican Health Study. [PDF]

Pharmacol Res Perspect
ABSTRACT Proton pump inhibitors (PPI), used to treat gastrointestinal disorders, are associated with alterations in the gut microbiome. However, this is understudied in Puerto Ricans who have unique lifestyle characteristics. Puerto Ricans, including participants of the Boston‐Puerto Rican Health Study (BPRHS), report high PPI use.
Dinesh D, Morgan XC, Kim H, Scott TM, Garelnabi M, Lee JS, Mangano KM, Nguyen LH, Huttenhower C, Tucker KL, Palacios N.   +10 more
europepmc   +2 more sources

MEP pathway products allosterically promote monomerization of deoxy-D-xylulose-5-phosphate synthase to feedback-regulate their supply [PDF]

, 2022
Isoprenoids are a very large and diverse family of metabolites required by all living organisms. All isoprenoids derive from the double-bond isomers isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), which are produced by the ...
Edward E.K. Baidoo, Adrian Velazquez-Campoy, Iglesias-Fernandez, Javier, Di, X., Lucia Diaz, Baidoo, Edward E. K, Diaz, Lucia, Perez-Gil, Jordi, Jordi Perez-Gil, Baidoo, EEK, Ortega-Alarcon, David, Rodríguez-Concepción, Manuel, Javier Iglesias-Fernandez, Velazquez, Adrian, Baidoo, Edward E.K., Velazquez-Campoy, Adrian, David Ortega-Alarcon, Di, Xueni, Manuel Rodríguez-Concepción, Ramu Kakumanu, Baidoo, Edward EK, Baidoo, Edward E. K., Kakumanu, Ramu, Xueni Di, Rodríguez Concepción, Manuel   +24 more
core   +1 more source

Hemostasis during cardiopulmonary bypass

, 2022
Cardiopulmonary bypass (CPB) extensively activates the hemostatic system. When blood comes into contact with nonendothelial surfaces, it activates platelets and factor XII triggering the coagulation intrinsic pathway.
Faggian, G., Tropea, I., Bernabei, A., Francica, A., Onorati, F.   +4 more
core   +1 more source

Toxic effect of the novel chiral insecticide IPP and its biodegradation intermediate in nematode Caenorhabditis elegans [PDF]

, 2018
Caenorhabditis elegans, a kind of model organism, was used to investigate biodegradation pathway of IPP and M1 in nematodes, in vivo toxicity from IPP and M1 and the possible underlying molecular mechanism.
Cai, Z., Zhuang, Z., Bian, T., Guo, J., Zhao, X., Zhu, X.   +5 more
core   +1 more source

A century of vitamin E research: The innovative journey from basic biology to synthetic bio-manufacturing. [PDF]

J Integr Plant Biol
For a century, Vitamin E has been studied for its health benefits. This review traces its journey from basic biological discovery, and the recent identification of its link to chlorophyll degradation, to the modern era of sustainable microbial manufacturing, highlighting the innovative technologies that define its future production.
Zhang R, Ren Y, Zhao Y, Zheng H, Luo Y, Liu Y, Wang L, Zhang L.   +7 more
europepmc   +2 more sources

Isopentenyl diphosphate (IPP)-bypass mevalonate pathways for isopentenol production [PDF]

, 2020
a b s t r a c t Branched C 5 alcohols are promising biofuels with favorable combustion properties. A mevalonate (MVA)-based isoprenoid biosynthetic pathway for C 5 alcohols was constructed in Escherichia coli using genes from several organisms, and the ...
Taek Soon Lee, George Wang, Jay D Keasling, Kevin W George, Edward Baidoo, Aram Kang   +5 more
core  

Simultaneous Disruption of Two DNA Polymerases, Pol eta and Pol zeta, in Avian DT40 Cells Unmasks the Role of Pol eta in Cellular Response to Various DNA Lesions [PDF]

, 2010
Replicative DNA polymerases are frequently stalled by DNA lesions. The resulting replication blockage is released by homologous recombination (HR) and translesion DNA synthesis (TLS). TLS employs specialized TLS polymerases to bypass DNA lesions.
Sonoda, E, Dávid Szüts, Hirota Kouji, Takuo Kawamoto, Shunichi Takeda, Motegi, Akira, Motegi Akira, Fumio Hanaoka, Kawamoto Takuo, Julian E. Sale, Kawamoto, Takuo, Iwai, Shigenori, Julian E Sale, Sale Julian E., Sonoda Eiichiro, Masutani Chikahide, Shigenori Iwai, Alan Lehmann, Masutani, C, Takeda, Shunichi, Iwai Shigenori, Lehmann, Alan, Chikahide Masutani, Szüts, Dávid, Iwai, S, Eiichiro Sonoda, Motegi, A, Kawamoto, T, Masutani, Chikahide, Kouji Hirota, Hanaoka Fumio, Szüts, D, Takeda Shunichi, Hirota, Kouji, Sale, Julian E, Szüts Dávid, Hanaoka, Fumio, Lehmann Alan, Takeda, S, Hirota, K, Hanaoka, F, Sale, JE, Akira Motegi, Sonoda, Eiichiro, Lehmann, A   +44 more
core   +1 more source