Genome-scale Metabolic Modeling Guided Escherichia coli Engineering for De Novo Biosynthesis of Chrysanthemic Acid. [PDF]
Adv Sci (Weinh)Genome‐scale metabolic modeling is preceded to the engineered E. coli cell factory for the de novo biosynthesis of biopesticide chrysanthemic acid. The debranching strategy redirects metabolic flux, enhancing precursor and target compound production.
Yu J +6 more
europepmc +2 more sources
Gut Microbial Variations Associated With Proton Pump Inhibitor Use in the Boston Puerto Rican Health Study. [PDF]
Pharmacol Res PerspectABSTRACT Proton pump inhibitors (PPI), used to treat gastrointestinal disorders, are associated with alterations in the gut microbiome. However, this is understudied in Puerto Ricans who have unique lifestyle characteristics. Puerto Ricans, including participants of the Boston‐Puerto Rican Health Study (BPRHS), report high PPI use.
Dinesh D +10 more
europepmc +2 more sources
Adenosine Triphosphate and Carbon Efficient Route to Second Generation Biofuel Isopentanol. [PDF]
, 2020 Climate change necessitates the development of CO2 neutral or negative routes to chemicals currently produced from fossil carbon. In this paper we demonstrate a pathway from the renewable resource glucose to next generation biofuel isopentanol by pairing
Chiniquy, Jennifer +9 more
core +1 more source
Balancing Cell Growth and Product Synthesis for Efficient Microbial Cell Factories. [PDF]
Adv Sci (Weinh)This review presents state‐of‐the‐art metabolic engineering strategies to balance microbial cell growth and product synthesis in biorefineries. It surveys pathway engineering, dynamic genetic circuits, orthogonal control systems, synthetic microbial consortia, and fermentation optimization, alongside integrative modeling approaches.
Liu L +5 more
europepmc +2 more sources
A century of vitamin E research: The innovative journey from basic biology to synthetic bio-manufacturing. [PDF]
J Integr Plant BiolFor a century, Vitamin E has been studied for its health benefits. This review traces its journey from basic biological discovery, and the recent identification of its link to chlorophyll degradation, to the modern era of sustainable microbial manufacturing, highlighting the innovative technologies that define its future production.
Zhang R +7 more
europepmc +2 more sources
Engineering The Unicellular Alga Phaeodactylum tricornutum For High-Value Plant Triterpenoid Production [PDF]
, 2018 Plant triterpenoids constitute a diverse class of organic compounds that play a major role in development, plant defense and environmental interaction. Several triterpenes have demonstrated potential as pharmaceuticals.
Allen, MJ +8 more
core +7 more sources
A Metabolic Dependency for Host Isoprenoids in the Obligate Intracellular Pathogen Rickettsia parkeri Underlies a Sensitivity to the Statin Class of Host-Targeted Therapeutics. [PDF]
, 2019 Gram-negative bacteria in the order Rickettsiales have an obligate intracellular growth requirement, and some species cause human diseases such as typhus and spotted fever.
Ahyong, Vida +4 more
core +2 more sources
From flavors and pharmaceuticals to advanced biofuels: Production of isoprenoids in Saccharomyces cerevisiae [PDF]
, 2013 Isoprenoids denote the largest group of chemicals in the plant kingdom and are employed for a wide range of applications in the food and pharmaceutical industry.
Ajikumar +70 more
core +2 more sources
Deconvoluting heme biosynthesis to target blood-stage malaria parasites [PDF]
, 2015 Heme metabolism is central to blood-stage infection by the malaria parasite Plasmodium falciparum. Parasites retain a heme biosynthesis pathway but do not require its activity during infection of heme-rich erythrocytes, where they can scavenge host heme ...
Crowley, Jan R +3 more
core +2 more sources
Gut microbiome-host interactions in health and disease [PDF]
, 2011 08/07/14 meb.
Darzi, AW, Kinross, JM, Nicholson, JK
core +1 more source