Results 31 to 40 of about 4,447 (126)

Lipolysis generates platelet dysfunction after in vivo heparin administration [PDF]

, 2002
Heparin, when administered to patients undergoing operations using cardiopulmonary bypass, induces plasma changes that gradually impair platelet macroaggregation, but heparinization of whole blood in vitro does not have this effect.
Day, S., Caslake, M.J., Wheatley, D.J., Day, SP, Caslake, MJ, Chaudhry, MA, Chaudhry, M.A., Muriithi, E.W., Wheatley, DJ, Muriithi, EW, Belcher, P.R., Belcher, PR   +11 more
core  

Advances in Erectile Dysfunction Management: What Does Work

Trends in Urology &Men's Health, Volume 17, Issue 3, June 2026.
ABSTRACT Erectile dysfunction (ED) is a prevalent and multifactorial disorder that substantially affects quality of life. Pathophysiology includes vascular, neurogenic, drug‐induced, and psychogenic causes, and frequently coexists with cardiometabolic disease.
Jolie Shen, Daye Park, Jasper Bash, Juan Andino   +3 more
wiley   +1 more source

Systematically Engineering for Efficient Production of 3‐Methyl‐1‐Butanol in Escherichia coli

Advanced Science, Volume 13, Issue 21, 13 April 2026.
An integrated metabolic engineering strategy was established for high‐level 3‐methyl‐1‐butanol biosynthesis in Escherichia coli. Molecular dynamics‐guided semi‐rational engineering of dihydroxyacid dehydratase uncovered and relieved key catalytic bottlenecks, while adaptive laboratory evolution enhanced strain robustness.
Nanfei Geng, Hao Liu, Haolin Han, Meng Meng, Shaojie Wang, Tianwei Tan, Haijia Su   +6 more
wiley   +1 more source

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, Volume 101, Issue 2, Page 751-803, April 2026.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

Heterologous Expression of the Mevalonic Acid Pathway in Cyanobacteria Enhances Endogenous Carbon Partitioning to Isoprene [PDF]

, 2014
Heterologous expression of the isoprene synthase gene in the cyanobacterium Synechocystis PCC 6803 conferred upon these microorganisms the property of photosynthetic isoprene (C₅H₈) hydrocarbons production.
Zurbriggen, Andreas, Melis, Anastasios, Bentley, Fiona K   +2 more
core   +1 more source

Metabolome and Transcriptome Profiling of Chicory Roots Provide Insights Into Laticifer Development and Specialized Metabolism

Physiologia Plantarum, Volume 178, Issue 1, January/February 2026.
ABSTRACT Chicory roots produce inulin, a dietary fiber, as well as large quantities of bitter sesquiterpene lactones (STLs), which have valuable biological activities. In an effort to understand the compartmentalization of metabolism within chicory roots and the molecular basis of the development of laticifers that produce the chicory latex, we ...
Khabat Vahabi, Gerd U. Balcke, Johanna C. Hakkert, Ingrid M. van der Meer, Benedikt Athmer, Alain Tissier   +5 more
wiley   +1 more source

Delivery and impact bypass in a karst aquifer with high phosphorus source and pathway potential

, 2012
Conduit and other karstic flows to aquifers, connecting agricultural soils and farming activities, are considered to be the main hydrological mechanisms that transfer phosphorus from the land surface to the groundwater body of a karstified aquifer.
Melland, Alice R., Kelly, Coran, Jordan, Phil, Meehan, Robert A., Wall, David P., Shortle, Ger, Mellander, Per-Erik   +6 more
core   +1 more source

Hormetic Effects of 7‐Ketocholesterol in Preventing Ferroptosis in Hepatocytes

Oxidative Medicine and Cellular Longevity, Volume 2026, Issue 1, 2026.
Background and Aims Ferroptosis, a form of cell death marked by iron dysregulation and lipid peroxidation, has been implicated in liver and neurodegenerative diseases. 7‐ketocholesterol (7KC), a cholesterol oxidation product, induces oxidative stress and inflammation at high concentrations.
Sarit Anavi, Nicole Giltman, Haim Zeigerman, Zecharia Madar, Oren Tirosh, Liang-Jun Yan   +5 more
wiley   +1 more source

Milk-derived tripeptides IPP (Ile-Pro-Pro) and VPP (Val-Pro-Pro) promote adipocyte differentiation and inhibit inflammation in 3T3-F442A cells

, 2015
Milk derived tripeptides IPP (Ile-Pro-Pro) and VPP (Val-Pro-Pro) have shown promise as anti-hypertensive agents due to their inhibitory effects on angiotensin converting enzyme (ACE).
Wu, Jianping, Chakrabarti, Subhadeep
core   +1 more source

Evidence of a Novel Mevalonate Pathway in Archaea [PDF]

, 2014
: Isoprenoids make up a remarkably diverse class of more than 25000 biomolecules that include familiar compounds such as cholesterol, chlorophyll, vitamin A, ubiquinone, and natural rubber.
Cao, Zheng, Tyler P. Korman, Korman, Tyler P, James U. Bowie, Tyler P. Korman (109601), Jeffrey M. Vinokur, Zheng Cao (562710), Vinokur, Jeffrey M, Bowie, James U, Jeffrey M. Vinokur (1325061), Zheng Cao, James U. Bowie (109603)   +11 more
core   +1 more source