Results 11 to 20 of about 3,566 (193)

M4-ipRGCs regulate contrast sensitivity in vision [PDF]

Cell Reports
Summary: Intrinsically photosensitive retinal ganglion cells (ipRGCs) in mice are comprised of at least 6 morphological subtypes, known as M1 to M6.
K.M. Daly, Xiaoyi Li, Shubham Rathore, Ruchi Komal, Corinne Beier, Grayson P. Ostermeyer, Joseph Leffler, Nazia M. Alam, Glen T. Prusky, Phyllis R. Robinson, Benjamin Sivyer, William N. Grimes, Jeffrey S. Diamond, R. Lane Brown, Samer Hattar   +14 more
doaj   +5 more sources

The Diverse Role of ipRGCs in Visual Perception Beyond Non-Image-Forming Functions. [PDF]

Eur J Neurosci
ABSTRACT The intrinsically photosensitive retinal ganglion cells (ipRGCs) are the third class of photoreceptors apart from rods and cones, containing the photopigment melanopsin and are characterized into different subtypes (M1–M6) that support conscious visual perception.
Parnami K, Bhattacharyya A.
europepmc   +4 more sources

Selective activation of ipRGC modulates working memory performance. [PDF]

PLoS ONE
Intrinsically photosensitive retinal ganglion cells (ipRGCs) are known to be sensitive to short-wavelength light (460-480 nm; blue or cyan light) and to play a role in regulating physiological responses such as circadian rhythms.
Yuta Suzuki, Shigeki Nakauchi, Hsin-I Liao   +2 more
doaj   +4 more sources

Bipolar cell networks underlying steady-state intensity encoding in intrinsically photosensitive retinal ganglion cells [PDF]

iScience
Summary: Intrinsically photosensitive retinal ganglion cells (ipRGCs) encode ambient light intensity at steady-state and drive physiology even in the absence of melanopsin, but the synaptic basis of such encoding remains unclear.
Shai Sabbah, Carin Papendorp, Inbar Behrendt, Hala Rasras, Jesse Cann, Megan L. Leyrer, Elizabeth Koplas, Marjo Beltoja, Cameron Etebari, Ali Noel Gunesch, Luis Carrete, Min Tae Kim, Gabrielle Manoff, Ananya Bhatia-Lin, Tiffany Zhao, Henry Dowling, Kevin L. Briggman, David M. Berson   +17 more
doaj   +2 more sources

Longitudinal Evaluation of Chromatic Pupillometry and Retinal Thickness in Dogs With Sudden Acquired Retinal Degeneration Syndrome. [PDF]

Vet Ophthalmol
ABSTRACT Objective To determine longitudinal changes in chromatic pupillary light reflexes (cPLR) and retinal layers in dogs with sudden acquired retinal degeneration syndrome (SARDS). Animals Studied Clinical evaluation: Fifteen SARDS‐affected and nine control dogs.
Kim S, Cooper AE, Maggs DJ, Marangakis AD, Nguyen T, Motta M, Thomasy SM.   +6 more
europepmc   +2 more sources

Tbr2-dependent parallel pathways regulate the development of distinct ipRGC subtypes. [PDF]

Commun Biol
SUMMARY The intrinsically photosensitive retinal ganglion cells (ipRGC) are the conduit between the retinas and brain regions responsible for non-image-forming and image-forming vision. In mice, six ipRGC subtypes have been discovered based on morphological characteristics, functions, and molecular profiles.
Kiyama T, Chen CK, Altay HY, Chen YJ, Sigala L, Su D, Eliason S, Amendt BA, Mao CA.   +8 more
europepmc   +4 more sources

A timeline of structural and functional consequences to ipRGCs in a mouse model of Alzheimer's disease. [PDF]

Neurobiol Aging
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects cognitive, sensory and motor systems, including the visual system and has a significant impact on autonomy and quality of life. Emerging evidence suggests that visual system abnormalities may enable early detection and monitoring for AD, appearing before cognitive ...
Recio BS, Pérez WA, Tjondropurnomo R, Hsu J, Ahmed S, Parikh S, Sun J, Mitra S, Goit RK, Brecha NC, Patel N, Matynia A, Müller LPS.   +12 more
europepmc   +3 more sources

Melanopsin Retinal Ganglion Cells Regulate Cone Photoreceptor Lamination in the Mouse Retina

Cell Reports, 2018
Summary: Newborn neurons follow molecular cues to reach their final destination, but whether early life experience influences lamination remains largely unexplored.
Adele R. Tufford, Jessica R. Onyak, Katelyn B. Sondereker, Jasmine A. Lucas, Aaron M. Earley, Pierre Mattar, Samer Hattar, Tiffany M. Schmidt, Jordan M. Renna, Michel Cayouette   +9 more
doaj   +2 more sources

Melanopsin-Mediated Post-Illumination Pupillary Response in Idiopathic Rapid Eye Movement (REM) Sleep Behavior Disorder and Parkinson's Disease. [PDF]

Mov Disord
Abstract Aims To conduct a case–control study to investigate melanopsin‐mediated post‐illumination pupillary response (PIPR) in patients with Parkinson's disease (PD), video‐polysomnography‐confirmed isolated/idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD), and age‐matched healthy controls (HC). Methods PIPR was measured at 6 s after
Chan JWY, Huang B, Gong S, Yang Y, Tang S, Chau SW, Chan NY, Li TM, Liu Y, Chan AYY, Ma KKY, Li SX, Tsoh J, Chong KKL, Roecklein KA, Mok VCT, Wing YK.   +16 more
europepmc   +2 more sources

Carbenoxolone blocks the light-evoked rise in intracellular calcium in isolated melanopsin ganglion cell photoreceptors. [PDF]

PLoS ONE, 2011
BackgroundRetinal ganglion cells expressing the photopigment melanopsin are intrinsically photosensitive (ipRGCs). These ganglion cell photoreceptors send axons to several central targets involved in a variety of functions.
Jayne R Bramley, Erin M Wiles, Patricia J Sollars, Gary E Pickard   +3 more
doaj   +2 more sources