Results 21 to 30 of about 3,566 (193)
Functional and morphological alterations of light detection circuits in postmortem retina from donors with different stages of Alzheimer’s-like pathology [PDF]
Communications BiologyDisruption of sleep and circadian rhythms is one of the earliest symptoms of Alzheimer’s disease (AD). Circadian entrainment and modulation of alertness are non-visual responses to light driven by intrinsically photosensitive retinal ganglion cells ...
Nicolae Sanda +13 more
doaj +2 more sources
eLife, 2019 The light environment greatly impacts human alertness, mood, and cognition by both acute regulation of physiology and indirect alignment of circadian rhythms. These processes require the melanopsin-expressing intrinsically photosensitive retinal ganglion
Alan C Rupp +7 more
doaj +3 more sources
eLife, 2017 The visual system consists of two major subsystems, image-forming circuits that drive conscious vision and non-image-forming circuits for behaviors such as circadian photoentrainment.
Kylie S Chew +17 more
doaj +4 more sources
PLoS ONE, 2013 Intrinsically photosensitive retinal ganglion cells (iprgcs) are depolarized by light by two mechanisms: directly, through activation of their photopigment melanopsin; and indirectly through synaptic circuits driven by rods and cones. To learn more about
Shijun Weng +2 more
doaj +2 more sources
Differential regulation of mTOR activity in retinal ganglion cells underlies their distinct susceptibility to ischemia/reperfusion [PDF]
Communications BiologyRetinal ischemia/reperfusion (I/R) injury drives progressive retinal ganglion cell (RGC) loss, yet mechanisms underlying neuronal type-specific vulnerability remain unclear.
Meizhen Zhu +5 more
doaj +2 more sources
Light, Sound, and Melatonin: Investigating Multisensory Pathways for Visual Restoration [PDF]
MedicinaMultisensory integration is fundamental for coherent perception and interaction with the environment. While cortical mechanisms of multisensory convergence are well studied, emerging evidence implicates specialized retinal ganglion cells—particularly ...
Dario Rusciano
doaj +2 more sources
Dying to Entrain: Regulating ipRGC Spacing [PDF]
Developmental Cell, 2013 In a recent issue of Neuron, Chen et al. (2013) show that apoptosis is required to ensure the even distribution of a class of retinal ganglion cells (ipRGCs), which sense luminance both intrinsically and through input from rods and cones. Disrupting apoptosis impairs photoentrainment mediated by rods/cones, but not that mediated by ipRGC-expressed ...
Pinto-Teixeira, Filipe, Desplan, Claude
openaire +3 more sources
The projections of ipRGCs and conventional RGCs to retinorecipient brain nuclei [PDF]
Journal of Comparative Neurology, 2020 ABSTRACT Retinal ganglion cells (RGCs), the output neurons of the retina, allow us to perceive our visual environment. RGCs respond to rod/cone input through the retinal circuitry, however, a small population of RGCs are in addition intrinsically photosensitive (ipRGCs) and project to unique targets in the brain to modulate a broad ...
Corinne Beier +3 more
openaire +3 more sources
Divergent projection patterns of M1 ipRGC subtypes [PDF]
Journal of Comparative Neurology, 2018 Abstract In addition to its well‐known role in pattern vision, light influences a wide range of non‐image forming, subconscious visual behaviors including circadian photoentrainment, sleep, mood, learning, and the pupillary light reflex.
Jennifer Y. Li, Tiffany M. Schmidt
openaire +2 more sources
Tbr2-expressing retinal ganglion cells are ipRGCs [PDF]
, 2020 Abstract The mammalian retina contains more than 40 retinal ganglion cell (RGC) subtypes based on their unique morphologies, functions, and molecular profiles. Among them, intrinsically photosensitive RGCs (ipRGCs) are the first specified RGC type that emerged from a common pool of retinal progenitor cells.
Chai-An Mao +7 more
openaire +1 more source