Photoimmunotherapy Inhibits Tumor Recurrence After Surgical Resection on a Pancreatic Cancer Patient-Derived Orthotopic Xenograft (PDOX) Nude Mouse Model [PDF]
, 2015 BackgroundPhotoimmunotherapy (PIT) uses a target-specific photosensitizer based on a near-infrared (NIR) phthalocyanine dye, IR700, to induce tumor necrosis after irradiation with NIR light to kill cancer cells, such as those that remain after surgery ...
Heim, Roger +11 more
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Real-Time Fluorescence Monitoring System for Optimal Light Dosage in Cancer Photoimmunotherapy
PharmaceuticalsBackground/Objectives: Near-infrared photoimmunotherapy (NIR-PIT) was recently approved for the treatment of unresectable locally advanced or recurrent head and neck cancers in Japan; however, only one clinical dose has been validated in clinical trials,
Hideki Tanaka +12 more
doaj +1 more source
In vivo effect of NIR-PIT for MDAMB468 tumor (one shot NIR-PIT).
, 2015 (A) NIR-PIT regimen. Fluorescence images were obtained at each time point as indicated. (B) In vivo fluorescence real-time imaging of tumor bearing mice in response to NIR-PIT.
Yuko Nakamura (645668) +5 more
core +1 more source
Near-infrared Photoimmunotherapy Targeting Cadherin-17 for Gastrointestinal Cancer Treatment
, 2021 In an ageing society, cancer incidence rate would continue to rise. Better cancer treatment to reduce disease burden and improve patients' quality of life is in urgent need.
core
HER2-positive breast cancer, characterized by the overexpression of HER2 receptors, often develops resistance to trastuzumab, limiting its therapeutic efficacy. In this study, we explore the use of photodynamic therapy (PDT) with a trastuzumab-IRDye700DX
Fernandez, Pedro Luis +7 more
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GFP fluorescence imaging of N87-GFP flank and disseminated peritoneal model.
, 2014 In vivo GFP fluorescence imaging of a N87-GFP flank tumor and disseminated peritoneal model. Colocalization of tra-IR700 and tra-IR800 was confirmed in the peritoneal disseminated tumor with fluorescence imaging.
Hisataka Kobayashi (1859) +2 more
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Target sequences with CpG methylation or single CpG dinucleotides show reduced binding to DEAF1.
, 2014 (A) EMSA was performed using 32P-labeled dsDNA probes with 6- and 8-space control probes (sequences in Fig. 2) and with 5-methylcytosine (mC*) bases in the second DEAF1 half-site.
Shivakumar Rajamanickam (678450) +5 more
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In vivo fluorescence imaging of MDAMB231 and MDAMB468 tumors.
, 2015 (A) In vivo cet-IR700 and mouse IgG-IR800 fluorescence real-time imaging of bilateral (right dorsum; MDAMB468, left dorsum; MDAMB231) flank tumors in mice.
Yuko Nakamura (645668) +5 more
core +1 more source
SensorsThe drug efficacy evaluation of tumor-selective photosensitive substances was expected to be enabled by imaging the fluorescence intensity in the tumor area.
Toshihiro Takamatsu +2 more
doaj +1 more source
Front Cover: EPR Characterisation of Phthalocyanine Radical Anions in Near‐Infrared Photocleavage of the Hydrophilic Axial Ligand of a Photoimmunotherapeutic Reagent, IR700 (ChemPhotoChem 1/2022) [PDF]
ChemPhotoChem, 2021 Osamu Inanami +4 more
openaire +1 more source