Results 91 to 100 of about 1,216 (154)

Metabolism‐Regulating Nanomedicines for Cancer Therapy

Advanced NanoBiomed Research, Volume 6, Issue 1, January 2026.
This review highlights metabolism‐regulating nanomedicines designed to target glycolytic, lipid, amino acid, and nucleotide pathways in tumors. By incorporating metabolism‐regulating agents into versatile nanocarriers such as liposomes, micelles, dendrimers, and engineered bacteria, these platforms achieve targeted delivery, controlled release ...
Xiao Wu, Shiyi Geng, Jian Yang
wiley   +1 more source

Safety and Efficacy Findings From a Phase Ib/II Study of ASP‐1929 Photoimmunotherapy With Pembrolizumab in Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma

Head &Neck, Volume 48, Issue 1, Page 160-174, January 2026.
ABSTRACT Background ASP‐1929 photoimmunotherapy—cetuximab conjugated to IRDye 700DX and red light (690 nm) for localized drug activation—results in rapid, selective cell killing. Methods This phase Ib/II open‐label study evaluated ASP‐1929 photoimmunotherapy plus pembrolizumab in patients with recurrent/metastatic HNSCC (≥ 1 accessible lesion, PD‐L1 ...
David M. Cognetti, Joseph M. Curry, Jennifer Johnson, Michael Kwon, Shirley Y. Su, Francisco Civantos, Coral Olazagasti, Joseph Valentino, Susanne M. Arnold, R. Bryan Bell, Michael K. Gibson, Kyle Mannion, Kathryn M. Van Abel, Katharine A. Price, Haiying Dong, Amy H. Thorne, Toshiaki Suzuki, Ann M. Gillenwater   +17 more
wiley   +1 more source

Theoretical and Experimental Studies on the Near‐Infrared Photoreaction Mechanism of a Silicon Phthalocyanine Photoimmunotherapy Dye: Photoinduced Hydrolysis by Radical Anion Generation

, 2020
Ligand release from IR700, a silicon phthalocyanine dye used in near-infrared (NIR) photoimmunotherapy, initiates cancer cell death after NIR absorption, although its photochemical mechanism has remained unclear.
Ando, Kanta, Takao Tsuneda, Kobayashi, Masato, Goto, Yuto, Ogawa, Mikako, Masato Kobayashi, Hideo Takakura, Tetsuya Taketsugu, Mei Harada, Taketsugu, Tetsuya, Tsuneda, Takao, Yuto Goto, Harada, Mei, Mikako Ogawa, Kanta Ando, Takakura, Hideo   +15 more
core   +1 more source

Emerging Advances in Nanomedicine for Targeted Cancer Photoimmunotherapy and Photo‐Immunometabolic Therapy

WIREs Nanomedicine and Nanobiotechnology, Volume 17, Issue 6, November/December 2025.
Schematic representation of nanoparticle‐mediated photothermal therapy (PTT) inducing anti‐tumor immune responses. Nanoparticles are administered to a tumor‐bearing mouse and accumulate at the tumor site. Upon laser irradiation, the nanoparticles generate reactive oxygen species (ROS) within cancer cells, leading to cellular apoptosis.
Alexander Chota, Paromita Sarbadhikary, Heidi Abrahamse, Blassan P. George   +3 more
wiley   +1 more source

In vivo effect of NIR-PIT for MDAMB231 tumor.

, 2015
(A) NIR-PIT regimen. Fluorescence images were obtained at each time point as indicated. (B) In vivo fluorescence real-time imaging of tumor bearing mice in response to NIR-PIT.
Yuko Nakamura (645668), Tadanobu Nagaya (789144), Hisataka Kobayashi (1859), Kazuhide Sato (662171), Toshiko Harada (789145), Peter L. Choyke (542638)   +5 more
core   +1 more source

Lysosomal Cathepsin S Escape Facilitates Near Infrared Light‐Triggered Pyroptosis Via an Antibody‐Indocyanine Green Conjugate

Advanced Science, Volume 12, Issue 34, September 11, 2025.
ICAM1 antibody‐bound ICG triggers tumor‐specific, caspase‐1‐independent pyroptosis via CTSS‐mediated GSDMD cleavage, activates antitumor immunity, and synergizes with anti–PD‐1 therapy, offering a non‐apoptotic strategy to overcome resistance in cancer treatment.
Fan Chen, Xue‐Fei Tian, Teng Yang, Yu‐Jie Dai, Da‐Yuan Chen, Hong‐Bo Chen, Takaya Shimura, Xin‐Fang Li, Chu‐Lin Sha, Qing Ji, Jun Cao, Mei‐Yu Fang, Jin‐Biao Shang, Jian‐Min Fang, Ye Lu, Wei‐Hui Zheng, Peng Guo, Wei‐Hong Tan   +17 more
wiley   +1 more source

Supplementary Figure 1 from Near Infrared Photoimmunotherapy in a Transgenic Mouse Model of Spontaneous Epidermal Growth Factor Receptor (EGFR)-expressing Lung Cancer

, 2017
Scheme of Ab-IR700 ...
Yuko Nakamura (645668), Fusa Ogata (4873270), Shuhei Okuyama (3955442), Tadanobu Nagaya (789144), Hisataka Kobayashi (1859), Kazuhide Sato (662171), Tieu Hoa (15070423), Zoe Weaver Ohler (15070417), Deborah Householder (15070420), Dagane Daar (11449578), Peter L. Choyke (542638)   +10 more
core   +1 more source

Photoimmunotherapy of residual disease after incomplete surgical resection in head and neck cancer models [PDF]

, 2016
Antibody-based photodynamic therapy, or photoimmunotherapy (PIT), is a novel, targeted cancer therapy, which can serve as both a diagnostic and a therapeutic agent.
Eben L. Rosenthal, Matthew D. Tucker, Esther de Boer, William R. Carroll, van Dam, Gooitzen M., Gooitzen M. van Dam, Brandwein-Gensler, Margaret S., Margaret S. Brandwein‐Gensler, Rosenthal, Eben L., Lindsay S. Moore, Melissa L. Korb, Carroll, William R., Jason M. Warram, Korb, Melissa L., de Boer, Esther, Tucker, Matthew D., Moore, Lindsay S., Warram, Jason M.   +17 more
core   +2 more sources

Comparative Analysis of Clinical Outcomes and Financial Aspects of Phototherapies and Immunotherapy for Cancer

Advanced Science, Volume 12, Issue 30, August 14, 2025.
This review compares clinical outcomes, translational progress, and global funding trends across cancer phototherapies—photodynamic, photothermal, and photoimmunotherapy—and conventional immunotherapy. It highlights differences in treatment efficacy, clinical trial status, financial investment, and regulatory challenges, providing a comprehensive ...
Deepak S. Chauhan, Kun Shao, Roopa Hebbandi Nanjundappa, Daniel‐Jiajun Yu, Marianne Stanford, Huile Gao, Channakeshava Sokke Umeshappa   +6 more
wiley   +1 more source

Near-Infrared Photoimmunotherapy Targeting Prostate Cancer with Prostate-Specific Membrane Antigen (PSMA) Antibody

, 2017
Prostate-specific membrane antigen (PSMA) is a membrane protein that is overexpressed manifold in prostate cancer and provides an attractive target for molecular therapy.
Tadanobu Nagaya, Fusa Ogata, Yuko Nakamura, Shuhei Okuyama, Yasuhiro Maruoka, Hisataka Kobayashi, Peter L. Choyke   +6 more
core   +1 more source