Results 71 to 80 of about 1,216 (154)

Near-infrared photoimmunotherapy (NIR-PIT) on cholangiocarcinoma using a novel catheter device with light emitting diodes

, 2020
Near-infrared photoimmunotherapy (NIR-PIT) is a novel therapy for cancers that uses NIR light and antibody-photosensitizer (IR700) conjugates. However, it is difficult to deliver NIR light into the bile duct for cholangiocarcinoma (CCA) from the ...
Kohei Nakajima, Yasuo Yoshikawa, Kuwatani, Masaki, Naoya Sakamoto, Ogawa, Mikako, Yoshikawa, Yasuo, Sakamoto, Naoya, Yuki Kodama, Kodama, Yuki, Hirata, Hajime, Nakajima, Kohei, Masaki Kuwatani, Hajime Hirata, Mikako Ogawa   +13 more
core   +1 more source

Near infrared photoimmunotherapy targeting bladder cancer with a canine anti-epidermal growth factor receptor (EGFR) antibody [PDF]

, 2018
Anti-epidermal growth factor receptor (EGFR) antibody therapy is used in EGFR expressing cancers including lung, colon, head and neck, and bladder cancers, however results have been modest. Near infrared photoimmunotherapy (NIR-PIT) is a highly selective
Fazekas-Singer, Judit, Sophia N. Karagiannis, Yasuhiro Maruoka, Deborah W. Knapp, Choyke, Peter L., Kobayashi, Hisataka, Ogata, Fusa, Amy K. LeBlanc, Karagiannis, Sophia N.; id_orcid, Judit Fazekas-Singer, Peter L. Choyke, Erika Jensen-Jarolim, Tadanobu Nagaya, Fusa Ogata, Maruoka, Yasuhiro, Jensen-Jarolim, Erika, LeBlanc, Amy K., Nagaya, Tadanobu, Shuhei Okuyama, Knapp, Deborah W., Hisataka Kobayashi, Okuyama, Shuhei   +21 more
core   +1 more source

Epidermal Growth Factor Receptor (EGFR)-targeted Photoimmunotherapy (PIT) for the Treatment of EGFR-expressing Bladder Cancer

, 2017
The use of light as a means of therapy for bladder cancer has a long history but has been hampered by a lack of tumor specificity and therefore, damage to the normal bladder mucosa.
Reema Railkar, Thomas Sanford, Piyush K. Agarwal, Srinivas Vourganti, Diana Haines, L. Spencer Krane, Sam J. Brancato, Hisataka Kobayashi, Peter L. Choyke, Q. Quentin Li, Mohammad Rashid Siddiqui   +10 more
core   +2 more sources

Antibody–Drug Conjugates and Peptide–Drug Conjugates: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 8, August 2026.
The graphic summarizes the design principles, intracellular trafficking, clinical progress, challenges, and future directions of antibody–drug conjugates (ADCs) and peptide–drug conjugates (PDCs). ADCs consist of a tumor‐targeting antibody, a chemical linker, and a potent payload, whereas PDCs use peptide ligands to deliver cytotoxic, radionuclide, or ...
Ruxi Zheng, Shuiquan Li, Zhigang Zhang, Mengke Niu, Jing Fei, Jiaojiao Zhang, Jianwei Zhou, Kongming Wu, Ming Yi, Tianye Li   +9 more
wiley   +1 more source

Biodistribution Study of Intravenously Injected Cetuximab-IRDye700DX in Cynomolgus Macaques

, 2016
Purpose: The use of receptor-targeted antibodies conjugated to photosensitizers is actively being explored to enhance treatment efficacy. To facilitate clinical testing, we evaluated cetuximab conjugated to IRDye700DX (IR700) in cynomolgus macaques ...
Rosenthal, E. L., French, D. N., Zinn, K. R., de Boer, E., Warram, J. M., Samuel, S., Schoeb, T. R.   +6 more
core   +1 more source

Nucleotide Metabolism in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu   +7 more
wiley   +1 more source

In Vitro Comparative Study of Near-Infrared Photoimmunotherapy and Photodynamic Therapy

, 2023
Near-infrared photoimmunotherapy (NIR-PIT) is a new phototherapy that utilizes a monoclonal antibody (mAb) against cancer antigens and a phthalocyanine dye, IRDye700DX (IR700) conjugate (mAb-IR700).
Makoto Shibutani, Nobuhiko Onda, Susumu Yamashita, Miho Kojima   +3 more
core   +1 more source

Near infrared photoimmunotherapy of cancer; possible clinical applications

Nanophotonics, 2021
Near-infrared photoimmunotherapy (NIR-PIT) is a new cancer treatment that uses an antibody-photo-absorber conjugate (APC) composed of a targeting monoclonal antibody conjugated with a photoactivatable phthalocyanine-derivative dye, IRDye700DX (IR700 ...
Wakiyama Hiroaki, Kato Takuya, Furusawa Aki, Choyke Peter L., Kobayashi Hisataka   +4 more
doaj   +1 more source

Theranostic Advancements in Brain Cancer: Promising Approaches for Emerging Therapy

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Strategies for improving intra‐arterial administration (A) and photodynamic therapy in brain cancer (B). Improving intra‐arterial (IA) administration and photodynamic therapy (PDT) for brain cancer involves enhancing tumor targeting and breaching the blood–brain barrier (BBB). Key strategies include super selective catheterization, using osmotic agents
Bipraban Khanra, Manoj Kumar Sarangi
wiley   +1 more source

Supplemental Figures from Epidermal Growth Factor Receptor (EGFR)-targeted Photoimmunotherapy (PIT) for the Treatment of EGFR-expressing Bladder Cancer

, 2017
Supplemental Figure 1: Expression of EGFR in cell lines; Supplemental Figure 2: In vitro analysis of pan IR700; Supplemental Figure 4: Pan IR700 based PIT induces cell death in 5637 cells; Supplemental Figure 5: Panitumumab or IR700 alone have no effects
Reema Railkar (4847722), Sam J. Brancato (15075159), Mohammad Rashid Siddiqui (15075153), Hisataka Kobayashi (1859), Piyush K. Agarwal (2135977), Q. Quentin Li (15075150), Thomas Sanford (212004), L. Spencer Krane (15075147), Diana Haines (14870852), Srinivas Vourganti (15075156), Peter L. Choyke (542638)   +10 more
core   +1 more source