Results 11 to 20 of about 1,216 (154)

Evaluation of In Vitro Phototoxicity of a Minibody-IR700 Conjugate Using Cell Monolayer and Multicellular Tumor Spheroid Models [PDF]

Cancers, 2021
Photodynamic therapy (PDT) is a treatment strategy that utilizes photosensitizers (PSs) and light of a specific wavelength to kill cancer cells. However, limited tumor specificity is still a drawback for the clinical application of PDT. To increase the therapeutic efficacy and specificity of PDT, a novel human minibody (MS5) that recognizes a cell ...
Petras Juzenas, Mouldy Sioud, Andrius Kleinauskas   +2 more
exaly   +4 more sources

Effect of Fluence Rate on Tumor Tissue Damage in IRDye700DX‐Based Photoimmunotherapy [PDF]

Cancer Medicine
Objective IRDye700DX‐based photoimmunotherapy (IR700‐based PIT) is a newly developed cancer phototherapy using an antibody–photosensitizer conjugate (APC).
Susumu Yamashita, Miho Kojima, Nobuhiko Onda, Makoto Shibutani   +3 more
doaj   +3 more sources

Adding Intratumoral Antibody-Photoabsorber Conjugate Improves Efficacy of Near-Infrared Photoimmunotherapy (NIR-PIT). [PDF]

Cancer Sci
Intravenous (IV) or intratumoral (IT) cetuximab distribution in A431 tumor (essence of Figure 2). ABSTRACT Near‐infrared photoimmunotherapy (NIR‐PIT) is a new type of cancer treatment that specifically kills target cells while sparing normal tissue. This treatment induces cancer cell death by activating a photoreactive dye with near‐infrared light in ...
Kano M, Furusawa A, Takao S, Kano M, Suzuki M, Yamamoto H, Okuyama S, Kitamura K, Choyke PL, Kobayashi H.   +9 more
europepmc   +2 more sources

Near‐infrared photoimmunotherapy in the models of hepatocellular carcinomas using cetuximab‐IR700

Cancer Science, 2023
AbstractEpidermal growth factor receptor (EGFR) has emerged as an important therapeutic target in many cancers, and overexpression of EGFR is frequently observed in hepatocellular carcinomas (HCCs). Near‐infrared photoimmunotherapy (NIR‐PIT) is a new anticancer treatment that selectively damages the cell membrane of cancer cells after NIR light‐induced
Aki Furusawa, Hisataka Kobayashi
exaly   +3 more sources

Phototoxicity in near-infrared photoimmunotherapy is influenced by the subcellular localization of antibody-IR700

Photodiagnosis and Photodynamic Therapy, 2020
Near-infrared photoimmunotherapy (NIR-PIT) is a newly developed cancer phototherapy that utilizes monoclonal antibody-IRDye700DX conjugates (mAb-IR700) and NIR light. We previously reported that mAb-IR700 aggregated on the plasma membrane and induced physical damage within the membrane, leading to necrotic/immunogenic cancer cell death.
Mikako Ogawa
exaly   +4 more sources

Morphological changes induced immediately after Tra-IR700-mediated PIT from Trastuzumab-Based Photoimmunotherapy Integrated with Viral HER2 Transduction Inhibits Peritoneally Disseminated HER2-Negative Cancer

, 2023
<p>Morphological changes induced immediately after Tra-IR700-mediated PIT in HER2-ECD-transduced gastric cancer cells captured as a time-lapse movie. The cells, which were treated with the integration of Ad/HER2-ECD and Tra-IR700-mediated PIT, shrunk without proliferation.
Toshiyoshi Fujiwara, Hisataka Kobayashi, Hiroshi Tazawa, Yasuhiro Shirakawa, Shunsuke Tanabe, Kazuhiro Noma, Kiyoto Takehara, Kyoko Shimoyama, Shunsuke Kagawa, Michihiro Ishida   +9 more
openaire   +2 more sources

Interleukin 15 (IL15)-based near-infrared photoimmunotherapy [PDF]

Cancer Immunology, Immunotherapy
Near-infrared photoimmunotherapy (NIR-PIT) is a highly selective cancer therapy based on a targeted monoclonal antibody conjugated to phthalocyanine-based photoabsorber, IRDye700DX (IR700). Following injection, near-infrared light activates the conjugate
Motofumi Suzuki, Aki Furusawa, Hiroshi Yamamoto, Makoto Kano, Miyu Kano, Seiichiro Takao, Shuhei Okuyama, Peter L. Choyke, Hisataka Kobayashi   +8 more
doaj   +2 more sources

Therapeutic potential of photoimmunotherapy in solid tumors expressing CD98 heavy chain [PDF]

Scientific Reports
Near-infrared photoimmunotherapy (NIR-PIT) is an emerging targeted cancer therapy that uses an antibody–photoabsorber conjugate. In this study, we evaluated the therapeutic potential of NIR-PIT targeting CD98 heavy chain (CD98hc), a transmembrane ...
Citra R. A. P. Palangka, Naoya Kondo, Ayaka Kanai, Hirofumi Hanaoka   +3 more
doaj   +2 more sources

Conjugation Ratio, Light Dose, and pH Affect the Stability of Panitumumab–IR700 for Near-Infrared Photoimmunotherapy

ACS Medicinal Chemistry Letters, 2020
Near-infrared photoimmunotherapy (NIR-PIT), a newly developed cancer-cell-specific therapy, relies on a monoclonal antibody-photoabsorber conjugate (APC) and is based on a photoinduced ligand release reaction. Local exposure of the tumor to NIR light induces rapid immunogenic necrotic cell death.
Aki Furusawa, Fuyuki Inagaki, Hisataka Kobayashi   +2 more
exaly   +4 more sources

Development of a Peptide-Based Photoimmunotherapy Drug Targeting PD-L1 [PDF]

Molecules
Near-infrared photoimmunotherapy (NIR-PIT) has recently attracted attention as a highly selective cancer treatment, with good treatment outcomes observed from the only antibody-based drug currently available for clinical use. However, since only a single
Takuya Otani, Naoya Kondo, Ayaka Kanai, Hirofumi Hanaoka   +3 more
doaj   +2 more sources