Results 31 to 40 of about 1,216 (154)

CD146‐Targeted Multimodal Image‐Guided Photoimmunotherapy of Melanoma

Advanced Science, 2019
For melanoma resistant to molecularly targeted therapy and immunotherapy, new treatment strategies are urgently needed. A molecularly targeted theranostic pair may thus be of importance, where the diagnostic probe facilitates patient stratification and ...
Weijun Wei, Dawei Jiang, Emily B. Ehlerding, Todd E. Barnhart, Yunan Yang, Jonathan W. Engle, Quan‐Yong Luo, Peng Huang, Weibo Cai   +8 more
doaj   +2 more sources

Near-Infrared Photoimmunotherapy in Brain Tumors—An Unexplored Frontier [PDF]

Pharmaceuticals
Near-infrared photoimmunotherapy (NIR-PIT) is a promising cancer treatment that uses near-infrared light to activate a conjugate of a monoclonal antibody (mAb) and a photoactivatable silica phthalocyanine dye (IRDye700DX: IR700).
Haruka Yamaguchi, Masayasu Okada, Takuya Otani, Jotaro On, Satoshi Shibuma, Toru Takino, Jun Watanabe, Yoshihiro Tsukamoto, Ryosuke Ogura, Makoto Oishi, Takamasa Suzuki, Akihiro Ishikawa, Hideyuki Sakata, Manabu Natsumeda   +13 more
doaj   +2 more sources

An Overview of Target Membrane Proteins for Near-Infrared Photoimmunotherapy [PDF]

Pharmaceuticals
Near-infrared photoimmunotherapy (NIR-PIT) is a recently developed cancer treatment that utilizes antibody–photoabsorber (IRDye700DX [IR700]) conjugates and NIR light.
Motofumi Suzuki, Hirofumi Hanaoka
doaj   +2 more sources

Near Infrared Photoimmunotherapy for Lung Cancer: Recent Development and Perspective [PDF]

ImmunoTargets and Therapy
Ryu Okada,1– 3,* Mizuki Yamada,1,3,4,* Mitsuo Sato,1,4 Kazuhide Sato1,3,51Graduate School of Medicine, Nagoya University, Nagoya, Japan; 2Research Unit for Life Sciences with Light Modulation, B3 Unit, Institute for Advanced Research ...
Okada R, Yamada M, Sato M, Sato K
doaj   +2 more sources

Metabolotheranostics of pancreatic cancer by targeting choline, glutamine, and glucose transporters with photoimmunotherapy [PDF]

npj Imaging
Altered choline, glutamine, and glucose metabolism form a triumvirate of metabolic reprogramming in most cancers that significantly influences growth, progression, and response to treatment.
Puneet Khandelwal, Jiefu Jin, James D. Barnett, Yelena Mironchik, Balaji Krishnamachary, Saleem Yousf, Raj Kumar Sharma, Hisataka Kobayashi, Zaver M. Bhujwalla   +8 more
doaj   +2 more sources

Real-time Fluorescence Imaging with IR700 Signal for Monitoring the Therapeutic Effects of Near-infrared Photoimmunotherapy [PDF]

THE SHINSHU MEDICAL JOURNAL
Aim : Near-infrared photoimmunotherapy (NIR-PIT) is a new, highly selective tumor treatment that employs a NIR phthalocyanine dye, IRDye 700DX (IR700), conjugated to a monoclonal antibody (mAb). Although NIR light exposure leads to immediate, target-selective necrotic cell death, actual tumor shrinkage occurs several days afterwards.
NAGAYA, Tadanobu
core   +4 more sources

SNAP‐Tag–Based Recombinant Photoimmunotherapeutic Agents for the Selective Detection and Killing of Light‐Accessible Melanotransferrin‐Expressing Melanoma and Triple‐Negative Breast Cancer [PDF]

Cancer Medicine
Background Melanoma and triple negative breast cancer (TNBC) represent the most aggressive skin and breast cancer subtypes and are associated with poor diagnostic and limited therapeutic options leading to poor prognosis.
Suzanne Hippolite Magagoum, Fleury Augustin Nsole Biteghe, Gael Tchokomeni Siwe, Dirk Lang, Nkhasi Lekena, Stefan Barth   +5 more
doaj   +2 more sources

Enhancing the efficacy of near-infrared photoimmunotherapy through intratumoural delivery of CD44–targeting antibody–photoabsorber conjugatesResearch in context [PDF]

EBioMedicine
Summary: Background: Photoimmunotherapy (PIT) is a potent modality for cancer treatment. The conventional PIT regimen involves the systemic delivery of an antibody–photoabsorber conjugate, followed by a 24-h waiting period to ensure adequate ...
Yuichi Adachi, Kotaro Miyake, Kika Ohira, Shingo Satoh, Kentaro Masuhiro, Ryuya Edahiro, Yuya Shirai, Maiko Naito, Yujiro Naito, Takayuki Shiroyama, Shohei Koyama, Haruhiko Hirata, Kota Iwahori, Izumi Nagatomo, Yoshito Takeda, Atsushi Kumanogoh   +15 more
doaj   +2 more sources

Immediate in vivo target-specific cancer cell death after near infrared photoimmunotherapy [PDF]

BMC Cancer, 2012
Background Near infrared (NIR) photoimmunotherapy (PIT) is a new type of cancer treatment based on a monoclonal antibody (mAb)-NIR phthalocyanine dye, (IR700) conjugate.
Mitsunaga Makoto, Nakajima Takahito, Sano Kohei, Kramer-Marek Gabriela, Choyke Peter L, Kobayashi Hisataka   +5 more
doaj   +3 more sources

EpCAM-targeted near-infrared photoimmunotherapy (NIR-PIT) for the treatment of breast cancer [PDF]

Annals of Medicine
Background Near-infrared photoimmunotherapy (NIR-PIT) is a targeted cancer treatment that uses antibody-IR700 conjugates and selectively destroys cancer cells expressing a target antigen when exposed to near-infrared (NIR) light.
Aki Furusawa, Seiichiro Takao, Motofumi Suzuki, Makoto Kano, Hiroshi Yamamoto, Miyu Kano, Peter Choyke, Hisataka Kobayashi   +7 more
doaj   +2 more sources