Results 21 to 30 of about 1,216 (154)

Surface Modification of Liposomes Using IR700 Enables Efficient Controlled Contents Release Triggered by Near-IR Light

Biological and Pharmaceutical Bulletin, 2020
Stimuli-responsive liposomes are promising drug carriers for cancer treatment because they enable controlled drug release and the maintenance of desired drug concentrations in tumor tissue. In particular, near-IR (NIR) light is a useful stimulus for triggering drug release from liposomes based on its advantages such as deep tissue penetration and ...
Mikako Ogawa, Motofumi Suzuki, Yusuke Kono   +2 more
exaly   +4 more sources

Synthetic zipper mediated pre-targeting system for near-infrared photoimmunotherapy [PDF]

iScience
Summary: Several strategies have gained attraction in cancer diagnosis and therapy, particularly to overcome the limitations associated with direct targeting approaches in radioimmunotherapy and photoimmunotherapy.
T.M. Mohiuddin, Chaoyu Zhang, Wenjie Sheng, Marwah Al-Rawe, Natalia El-Merhie, Felix Zeppernick, Ivo Meinhold-Heerlein, Ahmad Fawzi Hussain   +7 more
doaj   +2 more sources

Near-Infrared Photoimmunotherapy Targeting Esophagogastric Junction Adenocarcinoma With Fully Human Anti-EpCAM Antibody. [PDF]

Cancer Sci
Photoimmunotherapy (PIT) in vitro. OE19 cells formed blisters 3 h after laser illumination using adecatumumab‐IR700. ABSTRACT Near‐infrared photoimmunotherapy (NIR‐PIT) is a tumor‐specific treatment using monoclonal antibody (mAb) photosensitizer conjugates, followed by near‐infrared light irradiation.
Sasabe M, Takashima K, Sakashita S, Koga Y, Anzai T, Yang S, Saijou S, Ishikawa A, Yamaguchi T, Tanaka H, Yoda Y, Fujita T, Mitsunaga S, Yasunaga M, Yano T.   +14 more
europepmc   +2 more sources

Near Infrared Photoimmunotherapy Targeting EGFR Positive Triple Negative Breast Cancer: Optimizing the Conjugate-Light Regimen.

PLoS ONE, 2015
AimTriple-negative breast cancer (TNBC) is considered one of the most aggressive subtypes of breast cancer. Near infrared photoimmunotherapy (NIR-PIT) is a cancer treatment that employs an antibody-photosensitizer conjugate (APC) followed by exposure of ...
Tadanobu Nagaya, Kazuhide Sato, Toshiko Harada, Yuko Nakamura, Peter L Choyke, Hisataka Kobayashi   +5 more
doaj   +2 more sources

Interstitial pneumonia caused by Photoimmunotherapy with cetuximab-IR700 conjugate

Auris Nasus Larynx
Photoimmunotherapy (PIT) is a newly developed cancer therapy that uses the tumor-targeted monoclonal antibody cetuximab conjugated to the photoabsorbing dye IR700. It is currently approved for the treatment of unresectable, locally advanced, or locoregionally recurrent head and neck cancers in Japan.
Tomoyuki Ōtsuka, Minako Nishio
exaly   +3 more sources

Photoimmunotheranostics of epithelioid sarcoma by targeting CD44 or EGFR

Translational Oncology
Epithelioid sarcoma (ES) is a rare soft tissue neoplasm with high recurrence rates. Wide surgical resection remains the only potential curative treatment.
Jiefu Jin, James D. Barnett, Yelena Mironchik, John Gross, Hisataka Kobayashi, Adam Levin, Zaver M. Bhujwalla   +6 more
doaj   +2 more sources

Triggering anti-GBM immune response with EGFR-mediated photoimmunotherapy

BMC Medicine, 2022
Background Surgical resection followed by chemo-radiation postpones glioblastoma (GBM) progression and extends patient survival, but these tumours eventually recur.
Justyna Mączyńska, Florian Raes, Chiara Da Pieve, Stephen Turnock, Jessica K. R. Boult, Julia Hoebart, Marcin Niedbala, Simon P. Robinson, Kevin J. Harrington, Wojciech Kaspera, Gabriela Kramer-Marek   +10 more
doaj   +2 more sources

Evaluation of Fluorescence Intensity and Antitumor Effect Using Real-Time Imaging in Photoimmunotherapy

Pharmaceuticals, 2022
Photoimmunotherapy (PIT) is a promising tumor-selective treatment method that uses light-absorbing dye-conjugated antibodies and light irradiation. It has been reported that IR700 fluorescence changes with light irradiation. The purpose of this study was
Kenji Takashima, Yoshikatsu Koga, Takahiro Anzai, Kayo Migita, Toru Yamaguchi, Akihiro Ishikawa, Shingo Sakashita, Masahiro Yasunaga, Tomonori Yano   +8 more
doaj   +2 more sources

The Therapeutic Potential of Photoimmunotherapy as a Safe, Effective and Non-Toxic Treatment Option for Superficial Triple Negative Breast Cancer. [PDF]

Cancer Med
ABSTRACT Triple‐negative breast cancer (TNBC) is the most aggressive breast cancer subtype, lacking estrogen (ER), progesterone (PR), and human epidermal growth factor receptor (HER‐2) expression. It disproportionately affects women of African descent and has a poor clinical prognosis attributed to its acute heterogeneity, thereby causing elevated ...
Biteghe FAN, Mungra N, Malindi Z, Chalomie NET, Stanislas KA, Yasmin-Karim S, Mike Makrigiorgos G, Chipidza FE, Akinrinmade OA, Sridhar S, Barth S, Ngwa W.   +11 more
europepmc   +2 more sources

Local monitoring of photosensitizer transient states provides feedback for enhanced efficiency and targeting selectivity in photodynamic therapy

Scientific Reports, 2023
Photodynamic therapy (PDT) fundamentally relies on local generation of PDT precursor states in added photosensitizers (PS), particularly triplet and photo-radical states.
Elin Sandberg, Chinmaya V. Srambickal, Joachim Piguet, Haichun Liu, Jerker Widengren   +4 more
doaj   +2 more sources