Results 261 to 270 of about 81,945 (302)
Some of the next articles are maybe not open access.
SUMOylated IRF-1 shows oncogenic potential by mimicking IRF-2
Biochemical and Biophysical Research Communications, 2010Interferon regulatory factor-1 (IRF-1) is an interferon-induced transcriptional activator that suppresses tumors by impeding cell proliferation. Recently, we demonstrated that the level of SUMOylated IRF-1 is elevated in tumor cells, and that SUMOylation of IRF-1 attenuates its tumor-suppressive function. Here we report that SUMOylated IRF-1 mimics IRF-
Sun-Mi, Park +8 more
openaire +2 more sources
Review: Overlapping and Distinct Mechanisms Regulating IRF-3 and IRF-7 Function
Journal of Interferon & Cytokine Research, 2002Recent molecular, biochemical, and gene disruption studies have demonstrated the essential role of interferon (IFN) regulatory factor-3, (IRF-3) and IRF-7 in the activation of type I IFN gene expression and the induction of the antiviral state. Both transcription factors share structural and functional properties, as well as a common mechanism of ...
Marc J, Servant +2 more
openaire +2 more sources
IL-12 Is Dysregulated in Macrophages from IRF-1 and IRF-2 Knockout Mice
The Journal of Immunology, 1999Abstract Macrophages derived from IFN-regulatory factor-1 (IRF-1) and IRF-2 knockout (−/−) and wild-type (+/+) mice were utilized to examine the role of these transcription factors in the regulation of IL-12 mRNA and protein expression.
C A, Salkowski +5 more
openaire +2 more sources
Science Signaling, 2009
The ubiquitin-conjugating enzyme Ubc5 is required for the activation of interferon regulatory factor 3 during the mitochondrial antiviral response.
openaire +1 more source
The ubiquitin-conjugating enzyme Ubc5 is required for the activation of interferon regulatory factor 3 during the mitochondrial antiviral response.
openaire +1 more source
Regulation of Cell Growth by Transcription Factors, IRF-1 and IRF-2
1994Cytokine transmit signals to cell interior, resulting in the activation/repression of the genes critical for cell growth and differentiation. One class of cytokines is the interferons (IFNs), which represent a heterogeneous family of multifunctional cytokines that typically manifest antiviral activity.
Tadatsugu Taniguchi +5 more
openaire +1 more source
Journal of Interferon & Cytokine Research, 2002
Tuberculosis is the most prevalent infectious disease and causes more deaths than any other, yet only 5%-10% of people infected by the causative agent, Mycobacterium tuberculosis, will develop the disease. Thus, natural resistance among humans is the norm. Fundamental immune responses to M.
openaire +1 more source
Tuberculosis is the most prevalent infectious disease and causes more deaths than any other, yet only 5%-10% of people infected by the causative agent, Mycobacterium tuberculosis, will develop the disease. Thus, natural resistance among humans is the norm. Fundamental immune responses to M.
openaire +1 more source
Identification and characterization of the lamprey IRF gene
Immunology Letters, 2015Interferon regulatory factors (IRFs) are named for their ability to bind to and regulate interferon genes when an organism becomes infected with a virus. Numerous studies have revealed the versatile and critical functions of IRFs. In this study, an IRF gene from Lampetra japonica was identified and analyzed using bioinformatic methods. The L.
Yue, Pang +4 more
openaire +2 more sources
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2002
Interferon (IFN) regulatory factor-1 (IRF-1) was isolated by virtue of its affinity to specific DNA sequences in the IFN-beta promoter that mediate virus responsiveness. IRF-1 was the first factor identified of the IRF family and was most extensively characterized at the molecular level.
Andrea, Kröger +4 more
openaire +1 more source
Interferon (IFN) regulatory factor-1 (IRF-1) was isolated by virtue of its affinity to specific DNA sequences in the IFN-beta promoter that mediate virus responsiveness. IRF-1 was the first factor identified of the IRF family and was most extensively characterized at the molecular level.
Andrea, Kröger +4 more
openaire +1 more source
In vivo formation of IRF-1 homodimers
Biochimie, 1998Interferon regulatory factor 1 (IRF-1) is a transcriptional activator which exerts different biological activities. IRF-1 activates interferon induced genes as well as genes which are not directly linked to the interferon system, such as the ICE protease gene.
S, Kirchhoff +3 more
openaire +2 more sources
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2002
Tuberculosis is the most prevalent infectious disease and causes more deaths than any other, yet only 5%-10% of people infected by the causative agent, Mycobacterium tuberculosis, will develop the disease. Thus, natural resistance among humans is the norm. Fundamental immune responses to M.
openaire +1 more source
Tuberculosis is the most prevalent infectious disease and causes more deaths than any other, yet only 5%-10% of people infected by the causative agent, Mycobacterium tuberculosis, will develop the disease. Thus, natural resistance among humans is the norm. Fundamental immune responses to M.
openaire +1 more source