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Interferon Regulatory Factor (IRF)-1 and IRF-2 are Associated with Prognosis and Tumor Invasion in HCC

Annals of Surgical Oncology, 2012
Interferon regulatory factor (IRF)-1 and IRF-2 are transcriptional factors that mediate interferons functions; the loss of IRF-1 expression and gain of IRF-2 expression were associated with malignant phenotype in multiple cancers. However, their roles in the progression of hepatocellular carcinoma (HCC) remain poorly described.Immunohistochemistry was ...
Yong, Yi +11 more
openaire +2 more sources

Monogenic disorders of the IRF transcription factors

Journal of Experimental Medicine
Interferon regulatory factors (IRFs) are a family of transcription factors essential for immune system development and host defense. Beyond immunity, IRF6 plays an indispensable role in craniofacial development. Inborn errors of IRFs (IE-IRFs) are a group of rare monogenic disorders caused by damaging variants in the IRF family of genes. In this review,
Mattison P. Stojcic +3 more
openaire +2 more sources

Interferon Regulatory Factor 1(IRF-1) Activates Anti-Tumor Immunity via CXCL10/CXCR3 Axis in Hepatocellular Carcinoma (HCC)

Cancer Letters, 2021
Yihe Yan, Hamza O Yazdani, David A Geller +2 more
exaly

IRF-1

1998
Tak W. Mak +4 more
openaire +1 more source

High Amount of Transcription Factor IRF8 Engages AP1-IRF Composite Elements in Enhancers to Direct Type 1 Conventional Dendritic Cell Identity

Immunity, 2020
Theresa L Murphy, Ray A Ohara, Prachi Bagadia +2 more
exaly

IRF-4

1998
Tak W. Mak +4 more
openaire +1 more source

Interferon Regulatory Factor 1 (IRF-1) and IRF-2 Regulate PD-L1 Expression in Hepatocellular Carcinoma (HCC) Cells

Cancer Immunology, Immunotherapy, 2020
Yihe Yan, David A Geller
exaly

IRF-2

1998
Tak W. Mak +4 more
openaire +1 more source