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Structure of New Ferroverdins Recruiting Unconventional Ferrous Iron Chelating Agents [PDF]

Biomolecules, 2022
Ferroverdins are ferrous iron (Fe2+)-nitrosophenolato complexes produced by a few Streptomyces species as a response to iron overload. Previously, three ferroverdins were identified: ferroverdin A, in which three molecules of p-vinylphenyl-3-nitroso-4 ...
Loïc Martinet, Dominique Baiwir, Gabriel Mazzucchelli, Sébastien Rigali   +3 more
doaj   +2 more sources

Amphetamine-like Deferiprone and Clioquinol Derivatives as Iron Chelating Agents [PDF]

Molecules
The accumulation of iron in dopaminergic neurons can cause oxidative stress and dopaminergic neuron degeneration. Iron chelation therapy may reduce dopaminergic neurodegeneration, but chelators should be targeted towards dopaminergic cells. In this work,
Mahmoud El Safadi, Katie A. Wilson, Indigo J. Strudwicke, Megan L. O’Mara, Mohan Bhadbhade, Tristan Rawling, Andrew M. McDonagh   +6 more
doaj   +2 more sources

Incidence of Ocular Toxicity from Iron Chelating Agents at Siriraj Hospital

Siriraj Medical Journal, 2020
Objective: To determine the incidences of ocular toxicity and ocular findings, including structural and functional abnormalities, caused by iron chelating agents and detected by an electrophysiologic test at Siriraj Hospital.
Atiporn Thuangtong, Sirawadee Wiriyaudomchart, Ketsara Rungsiri   +2 more
doaj   +3 more sources

Management of transfusional iron overload – differential properties and efficacy of iron chelating agents

Journal of Blood Medicine, 2011
Janet L Kwiatkowski The Children's Hospital of Philadelphia, Division of Hematology and University of Pennsylvania School of Medicine, Philadelphia, PA, USA Abstract: Regular red cell transfusion therapy ameliorates disease-related morbidity and ...
Kwiatkowski JL
doaj   +4 more sources

Impact of Sappan Wood Extract as Iron Chelator Adjuvant on Iron Concentration and Macrophage Polarization in Rat Spleen [PDF]

Iranian Journal of Medical Sciences
Background: Iron accumulation in the spleen of thalassemia patients disrupts macrophage polarization, impairs immune function, and increases mortality.
Mohammad Ghozali, Ratu Safitri, Erick Khristian, Amethyst Puspita Ainni, Yasmi Purnamasari Kuntana, Muhamad Hasan Bashari, Jeri Nobia Purnama   +6 more
doaj   +2 more sources

Influence of iron- and zinc-chelating agents on neutrophil extracellular trap formation [PDF]

Central European Journal of Immunology, 2021
Release of neutrophil extracellular traps (NETs) is one of the neutrophils’ mechanisms involved in the response to infection. NETs are released from the cell in response to a biological or synthetic stimulus to entrap, immobilize and kill pathogens ...
Weronika Kuźmicka, Aneta Moskalik, Aneta Manda-Handzlik, Urszula Demkow, Małgorzata Wachowska, Olga Ciepiela   +5 more
doaj   +2 more sources

Examination of diverse iron-chelating agents for the protection of differentiated PC12 cells against oxidative injury induced by 6-hydroxydopamine and dopamine. [PDF]

Sci Rep, 2022
Hašková P, Applová L, Jansová H, Homola P, Franz KJ, Vávrová K, Roh J, Šimůnek T.   +7 more
europepmc   +3 more sources

Long-Term Effects of Iron Chelating Agents on Ocular Function in Patients with Thalassemia Major. [PDF]

Clin Ophthalmol, 2021
Nuzzi R, Geronazzo G, Tridico F, Nuzzi A, Caselgrandi P, Piga AG.   +5 more
europepmc   +3 more sources

Therapeutic potential of iron chelators in retinal vascular diseases [PDF]

International Journal of Ophthalmology, 2023
Iron is one of the necessary metal elements in the human body. There are numerous factors that control the balance of iron metabolism, and its storage and transportation mechanisms are intricate.
Yan Li, Zi-Xuan Cheng, Ting Luo, Hong-Bin Lyu   +3 more
doaj   +1 more source

Ferroptosis in Cardiovascular Disease and Cardiomyopathies: Therapeutic Implications of Glutathione and Iron Chelating Agents. [PDF]

Biomedicines
Dawi J, Affa S, Gonzalez E, Misakyan Y, Nikoghosyan D, Hajjar K, Kades S, Fardeheb S, Mirzoyan H, Venketaraman V.   +9 more
europepmc   +3 more sources