Results 1 to 10 of about 20,621 (305)

Amphetamine-like Deferiprone and Clioquinol Derivatives as Iron Chelating Agents [PDF]

Molecules
The accumulation of iron in dopaminergic neurons can cause oxidative stress and dopaminergic neuron degeneration. Iron chelation therapy may reduce dopaminergic neurodegeneration, but chelators should be targeted towards dopaminergic cells. In this work,
Mahmoud El Safadi, Katie A. Wilson, Indigo J. Strudwicke, Megan L. O’Mara, Mohan Bhadbhade, Tristan Rawling, Andrew M. McDonagh   +6 more
doaj   +4 more sources

Iron chelating agents for iron overload diseases

Thalassemia Reports, 2014
Although iron is an essential element for life, an excessive amount may become extremely toxic both for its ability to generate reactive oxygen species, and for the lack in humans of regulatory mechanisms for iron excretion.
Guido Crisponi, Valeria Marina Nurchi, Maria Antonietta Zoroddu   +2 more
doaj   +7 more sources

Structure of New Ferroverdins Recruiting Unconventional Ferrous Iron Chelating Agents [PDF]

Biomolecules, 2022
Ferroverdins are ferrous iron (Fe2+)-nitrosophenolato complexes produced by a few Streptomyces species as a response to iron overload. Previously, three ferroverdins were identified: ferroverdin A, in which three molecules of p-vinylphenyl-3-nitroso-4 ...
Loïc Martinet, Dominique Baiwir, Gabriel Mazzucchelli, Sébastien Rigali   +3 more
doaj   +2 more sources

Targeting Aging and Diseases Associated with Ferroptosis and Senescence Through Modulation of Iron, Oxidative Stress and Lipid Peroxidation [PDF]

Antioxidants
Ferroptosis and senescence are unique cellular processes that lead to irreversible cell abnormalities and tissue damage in many diseases, such as cancer, neurodegeneration, cardiac, liver, and kidney damage.
Malamati Kourti, George J. Kontoghiorghes   +1 more
doaj   +2 more sources

Incidence of Ocular Toxicity from Iron Chelating Agents at Siriraj Hospital

Siriraj Medical Journal, 2020
Objective: To determine the incidences of ocular toxicity and ocular findings, including structural and functional abnormalities, caused by iron chelating agents and detected by an electrophysiologic test at Siriraj Hospital.
Atiporn Thuangtong, Sirawadee Wiriyaudomchart, Ketsara Rungsiri   +2 more
doaj   +3 more sources

Harnessing microbial iron chelators to develop innovative therapeutic agents

Journal of Advanced Research, 2022
Background: Bacterial infections involving multidrug-resistant Gram-negative bacteria have become critically involved in the current antibiotic crisis.
Marta Ribeiro, Cátia A. Sousa, Manuel Simões   +2 more
doaj   +3 more sources

Examination of diverse iron-chelating agents for the protection of differentiated PC12 cells against oxidative injury induced by 6-hydroxydopamine and dopamine. [PDF]

Sci Rep, 2022
Hašková P, Applová L, Jansová H, Homola P, Franz KJ, Vávrová K, Roh J, Šimůnek T.   +7 more
europepmc   +3 more sources

Ferroptosis in Cardiovascular Disease and Cardiomyopathies: Therapeutic Implications of Glutathione and Iron Chelating Agents. [PDF]

Biomedicines
Dawi J, Affa S, Gonzalez E, Misakyan Y, Nikoghosyan D, Hajjar K, Kades S, Fardeheb S, Mirzoyan H, Venketaraman V.   +9 more
europepmc   +3 more sources

Chelating Agents in Chronic Iron Overload [PDF]

Clinical Pediatrics, 1966
Robert McDonald
openalex   +4 more sources

Therapeutic potential of iron chelators in retinal vascular diseases [PDF]

International Journal of Ophthalmology, 2023
Iron is one of the necessary metal elements in the human body. There are numerous factors that control the balance of iron metabolism, and its storage and transportation mechanisms are intricate.
Yan Li, Zi-Xuan Cheng, Ting Luo, Hong-Bin Lyu   +3 more
doaj   +1 more source