Iron chelating agents for iron overload diseases [PDF]
Thalassemia Reports, 2014 Although iron is an essential element for life, an excessive amount may become extremely toxic both for its ability to generate reactive oxygen species, and for the lack in humans of regulatory mechanisms for iron excretion.
Guido Crisponi +2 more
doaj +10 more sources
A Speciation Study on the Perturbing Effects of Iron Chelators on the Homeostasis of Essential Metal Ions. [PDF]
PLoS ONE, 2015 A number of reports have appeared in literature calling attention to the depletion of essential metal ions during chelation therapy on β-thalassaemia patients.
Guido Crisponi +6 more
doaj +9 more sources
SYNTHETIC CHELATING AGENTS IN IRON METABOLISM* [PDF]
Journal of Clinical Investigation, 1963 F. J. Cleton +2 more
openalex +4 more sources
The Transfer of Iron to Reticulocytes by Synthetic Chelating Agents* [PDF]
Journal of Clinical Investigation, 1964 J.V. Princiotto +3 more
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Potential of Application of Iron Chelating Agents in Ophthalmic Diseases. [PDF]
Semin Ophthalmol, 2021 The investigations discussed in this review indicate that iron may exacerbate different eye diseases. Therefore, it is plausible that reducing cellular or body iron stores could influence disease pathogenesis, so it is logical to consider the iron chelators' potential protective role in the various ophthalmic diseases in the form of topical eye drops ...
Ghaffarieh A, Ciolino JB.
europepmc +5 more sources
Pharmacogenetic Study of Deferasirox, An Iron Chelating Agent [PDF]
PLoS ONE, 2010 Abstract Abstract 2060 Transfusion associated iron overload induce systemic toxicity. Deferoxamine had been used to reduce iron induced toxicities by chelating iron but it is a short acting drug and needs parenteral administration.
Hyoung Jin Kang +12 more
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Development of iron-chelating agents for clinical use [editorial; comment] [PDF]
Blood, 1992 GM Brittenham
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Chelating Agents in Chronic Iron Overload [PDF]
Clinical Pediatrics, 1966 Robert McDonald
openalex +5 more sources
Novel Anthraquinone Derivatives and Their Complexes with Metal Ions with Anticancer Activity: Structure/Redox and Chelation Activity Correlations [PDF]
PharmaceuticalsBackground/Objectives: Some specific anthraquinone derivatives (AQs) are known to be used widely as effective chemotherapeutic agents in the treatment of cancer.
Olga Yu. Selyutina +10 more
doaj +2 more sources
A rapid assay for evaluation of iron-chelating agents in rats [PDF]
Blood, 1981 Abstract The animal assay of potential new iron-chelating agents is at present dependent on cumbersome and imprecise iron balance studies in hypertransfused rodents. We report the development of a radioisotope assay in intact rats based on the transient labeling by ferritin 59Fe of the main source of chelatable iron within hepatocytes ...
MJ Pippard, DK Johnson, Finch Ca
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