Results 31 to 40 of about 910,855 (274)

Deferasirox, an oral chelator in the treatment of iron overload

Italian Journal of Medicine, 2013
BACKGROUND Deferasirox is a once-daily oral iron chelator developed for treating iron overload complicating long-term transfusion therapy in patients with diseases such as beta-thalassemia and myelodysplastic syndromes. Iron overload can damage the liver,
I. Portioli
doaj   +1 more source

Ocular Toxicity of Iron Chelator Drugs among Thalassemia Patients; a Review [PDF]

, 2017
Transfusion dependent thalassemia is a hematological condition characterized by imbalance in synthesis of alpha and beta subunits of hemoglobin. The consequence of regular and repeated transfusions is iron deposition in different organs.
Nassiri, Nader, Hashemieh, Mozhgan
core   +1 more source

Iron Chelator Drugs in Transfusion Dependent Thalassemia: a Review

Armaghane Danesh Bimonthly Journal, 2020
Background & aim: Thalassemia syndromes are the most common inherited hemoglobinopathies in the world characterized by various degrees of defective production of the alpha or beta globin chains.
M Hashemieh
doaj  

Differential effects of the type of iron chelator on the absolute number of hematopoietic peripheral progenitors in patients with β-thalassemia major

Haematologica, 2013
Several studies have established an association between iron chelation therapy with deferasirox and hematopoietic improvement in patients with myelodysplastic syndromes. There are no data from patients with β-thalassemia major. In a cross-sectional study,
Gian Luca Forni, Marina Podestà, Marco Musso, Giovanna Piaggio, Khaled M. Musallam, Manuela Balocco, Sarah Pozzi, Alessandra Rosa, Francesco Frassoni   +8 more
doaj   +1 more source

Effects of different iron sources on growth performance, intestinal morphology, development, and cell proliferation in weanling piglets

Journal of Nutritional Science
The current study aimed to investigate the effects of different iron sources on growth performance and small intestinal health in weaned piglets. Two hundred and forty piglets (Duroc × Large White × Landrace, 9.52 ± 1.60 kg, 40 ± 2 d) were assigned to ...
Ping Kang, Guolong Song, Jiajun Fan, Dianchao Gu, Qingqing Lv, Bingzhao Shi, Qingliang Chen, Kun Qin, Yanling Kuang, Dan Wang, Qiaoling Wen, Huiling Zhu, Yulan Liu   +12 more
doaj   +1 more source

A Novel Combination Cancer Therapy with Iron Chelator Targeting Cancer Stem Cells via Suppressing Stemness [PDF]

, 2019
Excess iron causes cancer and is thought to be related to carcinogenesis and cancer progression including stemness, but the details remain unclear. Here, we hypothesized that stemness in cancer is related to iron metabolism and that regulating iron ...
Matsukawa, Akihiro, Hiroaki Sato, Katsura, Yuki, Akihiro Matsukawa, Kagawa, Shunsuke, Kazuhiro Noma, Yuki Katsura, Fujiwara, Toshiyoshi, Shunsuke Kagawa, Toshiyoshi Fujiwara, Kashima, Hajime, Chen, Yuehua, Komoto, Satoshi, Xing, Boyi, Tomonari Kasai, Takayuki Ninomiya, Takuya Kato, Ohara, Toshiaki, Tazawa, Hiroshi, Satoshi Komoto, Yasuhiro Shirakawa, Seno, Masaharu, Yasuko Tomono, Tomono, Yasuko, Kato, Takuya, Hajime Kashima, Masaharu Seno, Narusaka, Toru, Yuehua Chen, Sato, Hiroaki, Hiroshi Tazawa, Shirakawa, Yasuhiro, Toshiaki Ohara, Noma, Kazuhiro, Kasai , Tomonari, Ninomiya, Takayuki, Toru Narusaka, Boyi Xing   +37 more
core   +1 more source

Acute iron overload aggravates blood-brain barrier disruption and hemorrhagic transformation after transient focal ischemia in rats with hyperglycemia

IBRO Neuroscience Reports, 2022
Hemorrhagic transformation (HT) has been reported to be associated with a poor prognosis after acute ischemic stroke. Blood-brain barrier (BBB) damage is considered as the major pathophysiologic mechanism of HT.
Qian Wu, Chenchen Wei, Siqi Guo, Junfeng Liu, Hengyi Xiao, Simiao Wu, Bo Wu, Ming Liu   +7 more
doaj   +1 more source

The role of iron and iron chelators in zygomycosis [PDF]

Clinical Microbiology and Infection, 2009
Iron is an essential element for cell growth and development, contributing to DNA synthesis and regulating the G(1)-phase to S-phase transition. Moreover, iron is important for the virulence of the majority of microorganisms, and the function of the genes regulating iron uptake is coupled with the manifestations of the virulence phenotype.
openaire   +2 more sources

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

Ironing out Persisters? Revisiting the Iron Chelation Strategy to Target Planktonic Bacterial Persisters Harboured in Carbapenem-Resistant Escherichia coli

Microorganisms
Antibiotic resistance is a global health crisis. Notably, carbapenem-resistant Enterobacterales (CRE) pose a significant clinical challenge due to the limited effective treatment options.
Jia Hao Yeo, Nasren Begam, Wan Ting Leow, Jia Xuan Goh, Yang Zhong, Yiying Cai, Andrea Lay-Hoon Kwa   +6 more
doaj   +1 more source