Results 21 to 30 of about 910,855 (274)

Increase of reactive oxygen species by desferrioxamine during experimental Chagas' disease. [PDF]

, 2010
Oxidative stress is common in inflammatory processes associated with many diseases including Chagas' disease. The aim of the present study was to evaluate, in a murine model, biomarkers of oxidative stress together with components of the antioxidant ...
Olindo Assis Martins-Filho, Martins-Filho, Olindo Assis, Cláudia Martins Carneiro, Washington Luiz Tafuri, Santos, Silvana Maria Elói, Andréa Teixeira-Carvalho, Vieira, Paula Melo de Abreu, Carneiro, Cl??udia Martins, de Abreu Vieira, Paula Melo, Francisco, Amanda Fortes, Paula Melo de Abreu Vieira, Silvana Maria Elói-Santos, Silva, Maisa, Ara??jo, M??rcio Sobreira Silva, Tafuri, Washington Luiz, Araújo, Márcio Sobreira Silva, Carvalho, Andréa Teixeira de, Carvalho, Andr??a Teixeira, Pedrosa, Maria L??cia, Amanda Fortes Francisco, Arantes, Jerusa Marilda, Elói-Santos, Silvana Maria, Maisa Silva, Teixeira-Carvalho, Andréa, Jerusa Marilda Arantes, Márcio Sobreira Silva Araújo, Carneiro, Cláudia Martins, Martins Filho, Olindo Assis, Santos, Silvana Maria El??i, Pedrosa, Maria Lúcia, Maria Lúcia Pedrosa   +30 more
core   +1 more source

Synergistic intracellular iron chelation combinations: mechanisms and conditions for optimizing iron mobilization [PDF]

, 2015
Iron chelators are increasingly combined clinically but the optimal conditions for cellular iron mobilization and mechanisms of interaction are unclear.
Maciej Garbowski, Porter, John, Evangelia Vlachodimitropoulou Koumoutsea, Garbowski, Maciej, Vlachodimitropoulou Koumoutsea, Evangelia, John Porter   +5 more
core   +3 more sources

Deferiprone-induced arthropathy in thalassemia: MRI findings in a case

Indian Journal of Radiology and Imaging, 2009
Arthropathy is a well known side effect of the iron chelator deferiprone (L1); however, the imaging findings in deferiprone-induced arthropathy are not well known.
Gyan Chand, Veena Chowdhury, A Manchanda, Sapna Singh   +3 more
doaj   +1 more source

Cellular growth and mitochondrial ultrastructure of leishmania (Viannia) braziliensis promastigotes are affected by the iron chelator 2,2-dipyridyl. [PDF]

PLoS Neglected Tropical Diseases, 2013
BackgroundIron is an essential element for the survival of microorganisms in vitro and in vivo, acting as a cofactor of several enzymes and playing a critical role in host-parasite relationships.
Camila Mesquita-Rodrigues, Rubem F S Menna-Barreto, Leonardo Sabóia-Vahia, Silvia A G Da-Silva, Elen M de Souza, Mariana C Waghabi, Patrícia Cuervo, José B De Jesus   +7 more
doaj   +1 more source

β-catenin-IRP2-primed iron availability to mitochondrial metabolism is druggable for active β-catenin-mediated cancer

Journal of Translational Medicine, 2023
Background Although β-catenin signaling cascade is frequently altered in human cancers, targeting this pathway has not been approved for cancer treatment.
Yuting Wu, Shuhui Yang, Luyang Han, Kezhuo Shang, Baohui Zhang, Xiaochen Gai, Weiwei Deng, Fangming Liu, Hongbing Zhang   +8 more
doaj   +1 more source

Chelator-Free/Chelator-Mediated Radiolabeling of Colloidally Stabilized Iron Oxide Nanoparticles for Biomedical Imaging

Nanomaterials, 2021
The aim of this study was to develop a bioimaging probe based on magnetic iron oxide nanoparticles (MIONs) surface functionalized with the copolymer (p(MAA-g-EGMA)), which were radiolabeled with the positron emitter Gallium-68.
Sofia Papadopoulou, Argiris Kolokithas-Ntoukas, Evangelia-Alexandra Salvanou, Anastasios Gaitanis, Stavros Xanthopoulos, Konstantinos Avgoustakis, Maria Gazouli, Maria Paravatou-Petsotas, Charalampos Tsoukalas, Aristides Bakandritsos, Penelope Bouziotis   +10 more
doaj   +1 more source

Iron overload and chelation

Hematology, 2005
Iron is one of the most common elements in nature. As a transition metal it is very efficient in electron transport and redox reactions. The proteins and enzymes in which iron is an essential component play a key role in respiration, energy production, detoxification of harmful oxygen species and cell replication.
Chaim, Hershko, Gabriela, Link, Abraham M, Konijn, Z, Ioav Cabantchik   +3 more
openaire   +2 more sources

Advances in iron chelation therapy: transitioning to a new oral formulation

Drugs in Context, 2017
Iron overload is a concern for patients who require repeated red-blood-cell transfusions due to conditions such as sickle cell disease, thalassemia, or myelodysplastic syndromes.
Nirmish R Shah
doaj   +1 more source

Intracellular Iron Chelation Modulates the Macrophage Iron Phenotype with Consequences on Tumor Progression. [PDF]

PLoS ONE, 2016
A growing body of evidence suggests that macrophage polarization dictates the expression of iron-regulated genes. Polarization towards iron sequestration depletes the microenvironment, whereby extracellular pathogen growth is limited and inflammation is ...
Christina Mertens, Eman Abureida Akam, Claudia Rehwald, Bernhard Brüne, Elisa Tomat, Michaela Jung   +5 more
doaj   +1 more source

A phase 1 dose-escalation study: safety, tolerability, and pharmacokinetics of FBS0701, a novel oral iron chelator for the treatment of transfusional iron overload

Haematologica, 2011
Background There is still a clinical need for a well-tolerated and safe iron chelator for the treatment of transfusional iron overload. We describe the pharmacokinetic properties and safety data after 7 days of dosing of FBS0701, a novel oral, once-daily
Hugh Young Rienhoff, Vip Viprakasit, Lay Tay, Paul Harmatz, Elliott Vichinsky, Deborah Chirnomas, Janet L. Kwiatkowski, Amy Tapper, William Kramer, John B. Porter, Ellis J. Neufeld   +10 more
doaj   +1 more source