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Combined therapy of iron chelator and antioxidant completely restores brain dysfunction induced by iron toxicity. [PDF]
PLoS ONE, 2014 BACKGROUND: Excessive iron accumulation leads to iron toxicity in the brain; however the underlying mechanism is unclear. We investigated the effects of iron overload induced by high iron-diet consumption on brain mitochondrial function, brain synaptic ...
Jirapas Sripetchwandee +3 more
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Jurnal Kedokteran Diponegoro, 2020 Introduction: Thalassemia is an inherited disorder that decrease the rate of globin synthesis. Multiple blood transfusions in thalassemia patients leading to complications of hemosiderosis and hemochromatosis. Iron chelator aims to remove excess iron in
Sesa Amelia +3 more
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Clinically approved iron chelators influence zebrafish mortality, hatching morphology and cardiac function. [PDF]
PLoS ONE, 2014 Iron chelation therapy using iron (III) specific chelators such as desferrioxamine (DFO, Desferal), deferasirox (Exjade or ICL-670), and deferiprone (Ferriprox or L1) are the current standard of care for the treatment of iron overload.
Jasmine L Hamilton +5 more
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Iron limitation in M. tuberculosis has broad impact on central carbon metabolism
Communications Biology, 2022 An inhibitor of Mycobacterium tuberculosis (Mtb) survival acts as an iron chelator, demonstrating that iron deprivation alters Mtb cholesterol and central carbon metabolism.
Monique E. Theriault +9 more
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Effects of Deferasirox in Alzheimer’s Disease and Tauopathy Animal Models
Biomolecules, 2022 The accumulation of iron may contribute to Alzheimer’s disease (AD) and other tauopathies. The iron chelator desferrioxamine slows disease progression in AD patients.
Ping Kwan, Amy Ho, Larry Baum
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Journal of Internal Medicine, 1997 Desferrioxamine (DFX) remains the most effective and safe iron chelator for treatment of patients with transfusional iron overload. It is usually given by intermittent subcutaneous infusions for 8–12 h on 4–6 days weekly using a battery‐driven pump. Disposable balloon infusers provide a suitable method of giving continuous subcutaneous infusions with ...
A V, Hoffbrand, B, Wonke
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Inhibitory effects of iron depletion plus eribulin on the breast cancer microenvironment
BMC Cancer, 2020 Background Iron is required for the proliferation of cancer cells, and its depletion suppresses tumor growth. Eribulin mesylate (eribulin), a non-taxane microtubule inhibitor, disrupts the tumor microenvironment via vascular remodeling and obstruction of
Wataru Goto +12 more
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Antioxidants, 2021 Skin is one of the main targets of the outdoor stressors. Considering that pollution levels are rising progressively, it is not surprising that several cutaneous conditions have been associated with its exposure.
Erika Pambianchi +6 more
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Veterinary Research, 2020 Salmonid Rickettsial Septicaemia (SRS), caused by Piscirickettsia salmonis, is a severe bacterial disease in the Chilean salmon farming industry. Vaccines and antibiotics are the current strategies to fight SRS; however, the high frequency of new ...
Mario Caruffo +11 more
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Iron Chelators in Treatment of Iron Overload
Journal of Toxicology, 2022 Patients suffering from iron overload can experience serious complications. In such patients, various organs, such as endocrine glands and liver, can be damaged. Although iron is a crucial element for life, iron overload can be potentially toxic for human cells due to its role in generating free radicals. In the past few decades, there has been a major
Sarina Entezari +9 more
openaire +3 more sources