Results 11 to 20 of about 910,855 (274)

Quantitative evaluation of iron chelator effects on central motor and sensory tracts in superficial siderosis [PDF]

Frontiers in Neurology
BackgroundSuperficial siderosis (SS) is a rare neurodegenerative disease characterized by hemosiderin deposition in the central nervous system, leading to progressive neuronal degeneration.
Ryo Iwase, Nobuo Sanjo, Tadashi Kanouchi, Yurie Nose, Miho Akaza, Motonori Hashimoto, Satoru Egawa, Toshitaka Yoshii, Takanori Yokota   +8 more
doaj   +2 more sources

Improvement of Left Ventricular Graft Function Using an Iron-Chelator-Supplemented Bretschneider Solution in a Canine Model of Orthotopic Heart Transplantation [PDF]

Int J Mol Sci, 2022
Demand for organs is increasing while the number of donors remains constant. Nevertheless, not all organs are utilized due to the limited time window for heart transplantation (HTX).
Karck, Matthias, Matthias Karck, Merkely, Béla, Sivakkanan Loganathan, Radovits, Tamás, Veres, Gábor, Zoltan Papp, Gábor Veres, Béla Merkely, Tamás Radovits, Brlecic, Paige, Gábor Szabó, Hegedüs, Péter, Paige Brlecic, Sevil Korkmaz-Icöz, Balogh, Ágnes, Papp, Zoltan, Ágnes Balogh, Korkmaz-Icöz, Sevil, Péter Hegedüs, Szabó, Gábor, Loganathan, Sivakkanan, Szabó, Gábor Tamás   +22 more
core   +2 more sources

Chelator-facilitated removal of iron from transferrin: Relevance to combined chelation therapy [PDF]

, 2008
Current iron chelation therapy consists primarily of DFO (desferrioxamine), which has to be administered via intravenous infusion, together with deferiprone and deferasirox, which are orally-active chelators.
Evans, PJ, Evans, RW, Hider, RC, Devanur, LD   +3 more
core   +8 more sources

The iron chelator deferoxamine decreases myeloma cell survival [PDF]

Journal of International Medical Research, 2021
Objective This study evaluated serum ferritin (SF) levels and investigated their relationships with various clinical markers in patients with multiple myeloma (MM).
Feifei Yang, Zhaoxian Wu, Dan Dai, Lei Zhang, Xiuqun Zhang, Xuezhong Zhang, Yanli Xu   +6 more
doaj   +2 more sources

Spermine: an endogenous iron chelator that suppresses ferroptosis [PDF]

Molecular Biomedicine
Yutian Xia
doaj   +2 more sources

Eltrombopag: a powerful chelator of cellular or extracellular iron(III) alone or combined with a second chelator [PDF]

, 2017
Eltrombopag (ELT) is a thrombopoietin receptor agonist, also reported to decrease labile iron in leukemia cells. Here we examine the previously undescribed iron(III)-coordinating and cellular iron-mobilizing properties of ELT.
Cooper, N, Koonyosying, P, Hider, R, Garbowski, M, Vlachodimitropoulou, E, Porter, J, Sola-Visner, M, Chen, Y-L, Psaila, B   +8 more
core   +2 more sources

Development of a mugineic acid family phytosiderophore analog as an iron fertilizer

Nature Communications, 2021
Iron is an essential plant nutrient that is poorly bioavailable in alkaline soils, resulting in reduced agricultural productivity. Here, the authors report the synthesis of stable and cheap iron-chelator, proline-2’-deoxymugineic acid (PDMA), and ...
Motofumi Suzuki, Atsumi Urabe, Sayaka Sasaki, Ryo Tsugawa, Satoshi Nishio, Haruka Mukaiyama, Yoshiko Murata, Hiroshi Masuda, May Sann Aung, Akane Mera, Masaki Takeuchi, Keijo Fukushima, Michika Kanaki, Kaori Kobayashi, Yuichi Chiba, Binod Babu Shrestha, Hiromi Nakanishi, Takehiro Watanabe, Atsushi Nakayama, Hiromichi Fujino, Takanori Kobayashi, Keiji Tanino, Naoko K. Nishizawa, Kosuke Namba   +23 more
doaj   +1 more source

Novel Iron Chelator SK4 Drives Cytotoxicity through Inhibiting Mitochondrial Metabolism in Ovarian and Triple Negative Breast Cancer Cell Lines

Biomedicines, 2023
Anti-cancer therapy by iron chelation has been shown to inhibit many cellular processes including DNA replication, mitochondrial metabolism and oncogenic signalling pathways (e.g., EGFR).
Gina Abdelaal, Andrew Carter, William Cheung, Mihalis Panayiotidis, Seth Racey, David Tétard, Stephany Veuger   +6 more
doaj   +1 more source

Polymeric Iron Chelator with Enhanced Iron Affinity as a Broad-Spectrum Antifungal Agent

, 2021
Developing broad-spectrum antifungal drugs represents a pressing need for reducing the global burden of fungal infections. We took advantage of the conformational stability effect to develop a high-avidity polymeric iron chelator, 2,3-dihydroxybenzoic ...
Nathan P. Wiederhold, Hoja Patterson, Jian Qian (379689), Cory J. Berkland, Thomas Patterson (2420905), Thomas Patterson, Jian Qian, Cory J. Berkland (737657), Nathan P. Wiederhold (5063837), Hoja Patterson (11706322)   +9 more
core   +1 more source

Using substantial reductant concentration with chelation therapy to enhance small aggregate dispersal, iron mobilization, and its clearance in neurodegenerative diseases

Frontiers in Neuroscience, 2022
Connections between altered iron homeostasis and certain neurodegenerative diseases are highlighted by numerous studies suggesting iron neurotoxicity. Iron causes aggregation in neurodegenerative disease-linked proteins as well as others and additionally
Barry B. Muhoberac
doaj   +1 more source