Results 1 to 10 of about 16,169 (250)

Tryptophan Metabolites as Mediators of Microbiota-Gut-Brain Communication: Focus on Isatin

Frontiers in Behavioral Neuroscience, 2022
Isatin (indole-2,3-dione) is an endogenous regulator, exhibiting various behavioral, biological, and pharmacological activities. Synthesis of isatin includes several crucial stages: cleavage of the tryptophan side chain and subsequent oxidation of the ...
Alexei Medvedev, Olga Buneeva
doaj   +2 more sources

A Mini Review on Isatin, an Anticancer Scaffold with Potential Activities against Neglected Tropical Diseases (NTDs)

Pharmaceuticals, 2022
Isatin, chemically an indole-1H-2,3-dione, is recognised as one of the most attractive therapeutic fragments in drug design and development. The template has turned out to be exceptionally useful for developing new anticancer scaffolds, as evidenced by ...
Shefali Chowdhary, Shalini, Amandeep Arora, Vipan Kumar   +3 more
doaj   +2 more sources

Ueber das Isatin [PDF]

Berichte der deutschen chemischen Gesellschaft, 1882
n ...
Adolf Baeyer, Spir. Oekonomides
openalex   +5 more sources

Isatin Counteracts Diethylnitrosamine/2-Acetylaminofluorene-Induced Hepatocarcinogenesis in Male Wistar Rats by Upregulating Anti-Inflammatory, Antioxidant, and Detoxification Pathways

Antioxidants, 2022
Hepatocellular carcinoma (HCC) represents around 85% of all known types of liver cancers and is estimated to be the fifth most common cause of cancer-related death worldwide.
Nagwa G. Tawfik, Wafaa R. Mohamed, Hanan S. Mahmoud, Mohammed A. Alqarni, Ibrahim A. Naguib, Alzhraa M. Fahmy, Osama M. Ahmed   +6 more
doaj   +2 more sources

Encapsulation of an anticancer drug Isatin inside a host nano-vehicle SWCNT: a molecular dynamics simulation

Scientific Reports, 2021
The use of carbon nanotubes as anticancer drug delivery cargo systems is a promising modality as they are able to perforate cellular membranes and transport the carried therapeutic molecules into the cellular components.
Maryam Zarghami Dehaghani, Farrokh Yousefi, Farzad Seidi, Babak Bagheri, Amin Hamed Mashhadzadeh, Ghasem Naderi, Amin Esmaeili, Otman Abida, Sajjad Habibzadeh, Mohammad Reza Saeb, Maksym Rybachuk   +10 more
doaj   +2 more sources

Therapeutic Outcomes of Isatin and Its Derivatives against Multiple Diseases: Recent Developments in Drug Discovery

Pharmaceuticals, 2022
Isatin (1H indole 2, 3-dione) is a heterocyclic, endogenous lead molecule recognized in humans and different plants. The isatin nucleus and its derivatives are owed the attention of researchers due to their diverse pharmacological activities such as ...
Rameshwar S. Cheke, Vaishali M. Patil, Sandip D. Firke, Jaya P. Ambhore, Iqrar A. Ansari, Harun M. Patel, Sachin D. Shinde, Visweswara Rao Pasupuleti, Md Imtaiyaz Hassan, Mohd Adnan, Adel Kadri, Mejdi Snoussi   +11 more
doaj   +2 more sources

Ueber Isatin. Vorläufige Mittheilung [PDF]

Journal für Praktische Chemie, 1884
n ...
H. Kolbe
openalex   +5 more sources

Development of Novel Isatin-Tethered Quinolines as Anti-Tubercular Agents against Multi and Extensively Drug-Resistant Mycobacterium tuberculosis

Molecules, 2022
We describe the design and synthesis of two isatin-tethered quinolines series (Q6a–h and Q8a–h), in connection with our research interest in developing novel isatin-bearing anti-tubercular candidates.
Mohamed A. Abdelrahman, Hadia Almahli, Tarfah Al-Warhi, Taghreed A. Majrashi, Marwa M. Abdel-Aziz, Wagdy M. Eldehna, Mohamed A. Said   +6 more
doaj   +2 more sources

A survey of isatin hybrids and their biological properties. [PDF]

Mol Divers
The emergence of diverse infections worldwide, which is a serious global threat to human existence, necessitates the urgent development of novel therapeutic candidates that can combat these diseases with efficacy.
Shu VA, Eni DB, Ntie-Kang F.
europepmc   +2 more sources

Ueber Condensationsproducte des Isatins [PDF]

Berichte der deutschen chemischen Gesellschaft, 1885
n ...
Adolf Baeyer, M. J. Lazarus
openalex   +4 more sources