Results 11 to 20 of about 16,503 (251)

Integrating Catalysis and Analysis: Accelerated Asymmetric Reaction Development With a Multitasking Reactivity Umpolung/Chiroptical Reporter Auxiliary. [PDF]

Chemistry
A readily available isatin molecule serves as amine protecting group, reagent for reactivity Umpolung, and as chiroptical yield and enantioselectivity reporter to enable chromatography‐free high‐throughput optimization of an organocatalytic asymmetric Michael addition solely based on the analysis of UV and circular dichroism inductions that are ...
Kariapper FS, Bouda M, Wolf C.
europepmc   +2 more sources

In Vitro and In Silico Evaluation of Isatin-Derived Spirooxindoles as Antituberculosis Drug Candidates. [PDF]

Chem Biol Drug Des
Two compounds, A16 and A17, were active against multidrug‐resistant Mycobacterium tuberculosis isolates (PT‐12 and PT‐20), overcoming key resistance mutations in katG and rpoB, while cytotoxicity assays confirmed that they are non‐toxic. A17 exhibited the highest antituberculosis activity, with molecular docking suggesting enoyl‐[acyl‐carrier‐protein ...
de Lima FR, de Oliveira Viana J, de Castro AC, Cristiano R, Perelló MA, Czeczot AM, Bizarro CV, Machado P, Basso LA, Lima-Junior CG, Rodrigues-Junior VDS, Weber KC.   +11 more
europepmc   +2 more sources

Encapsulation of an anticancer drug Isatin inside a host nano-vehicle SWCNT: a molecular dynamics simulation

Scientific Reports, 2021
The use of carbon nanotubes as anticancer drug delivery cargo systems is a promising modality as they are able to perforate cellular membranes and transport the carried therapeutic molecules into the cellular components.
Maryam Zarghami Dehaghani, Farrokh Yousefi, Farzad Seidi, Babak Bagheri, Amin Hamed Mashhadzadeh, Ghasem Naderi, Amin Esmaeili, Otman Abida, Sajjad Habibzadeh, Mohammad Reza Saeb, Maksym Rybachuk   +10 more
doaj   +1 more source

Estimation of isatin in spiked plasma samples using high performance liquid chromatography [PDF]

Chemical Industry and Chemical Engineering Quarterly, 2013
An isocratic analytical method based on liquid chromatographic determination with UV detection is described for the determination of isatin in spiked plasma and in its synthetic mixture.
Alothman Zeid A., Siddiqui Masoom R., Wabaidur Saikh M.   +2 more
doaj   +1 more source

Synthese des Isatins [PDF]

Berichte der deutschen chemischen Gesellschaft, 1879
n ...
Claisen, L., Shadwell, J.
openaire   +2 more sources

Isatin Counteracts Diethylnitrosamine/2-Acetylaminofluorene-Induced Hepatocarcinogenesis in Male Wistar Rats by Upregulating Anti-Inflammatory, Antioxidant, and Detoxification Pathways

Antioxidants, 2022
Hepatocellular carcinoma (HCC) represents around 85% of all known types of liver cancers and is estimated to be the fifth most common cause of cancer-related death worldwide.
Nagwa G. Tawfik, Wafaa R. Mohamed, Hanan S. Mahmoud, Mohammed A. Alqarni, Ibrahim A. Naguib, Alzhraa M. Fahmy, Osama M. Ahmed   +6 more
doaj   +1 more source

A Mini Review on Isatin, an Anticancer Scaffold with Potential Activities against Neglected Tropical Diseases (NTDs)

Pharmaceuticals, 2022
Isatin, chemically an indole-1H-2,3-dione, is recognised as one of the most attractive therapeutic fragments in drug design and development. The template has turned out to be exceptionally useful for developing new anticancer scaffolds, as evidenced by ...
Shefali Chowdhary, Shalini, Amandeep Arora, Vipan Kumar   +3 more
doaj   +1 more source

Synthesis of substituted isatins [PDF]

Tetrahedron Letters, 2013
AbstractAcid‐promoted cyclization of alkoximinoacetanilides is developed to provide a convenient synthesis of a broad spectrum of isatins bearing lipophilic substituents.
Michael D. Tufano, Larry L. Klein
openaire   +4 more sources

Imide and isatin derivatives as β-lactam mimics of β-lactam antibiotics [PDF]

, 2002
Activated γ-lactams, which are derivatives of succinimide, phthalimide and isatin with suitable elements of molecular recognition, have been synthesised as mimics of the ß-lactam antibiotics and their chemical and biological reactivity ...
Casey, Lorraine A., Galt, Ronald H. B., Hadfield, Peter S., Page, Michael I., Vilanova, Bartholomew   +4 more
core   +1 more source

5-(Trifluoromethoxy)isatin [PDF]

Acta Crystallographica Section E Structure Reports Online, 2012
THE TITLE COMPOUND [SYSTEMATIC NAME: 5-(trifluoro-meth-oxy)-1H-indole-2,3-dione], C9H4F3NO3, crystallized with two mol-ecules in the asymmetric unit. Inter-molecular N-H⋯O hydrogen bonds link the mol-ecules to form layers parallel to the ab plane. In addition, π-π stacking inter-actions are observed with a centroid-centroid distance of 3.721 (1) Å. The
Andreas Roodt, Carla Pretorius, Hendrik G. Visser, Marietjie Schutte   +3 more
openaire   +4 more sources