Results 21 to 30 of about 23,803 (294)
ACS Omega, 2022 Monoamine oxidase (MAO) is a protein with a key function in the catabolism of neuroamines in both central and peripheral parts of the body. MAO-A and -B are two isozymes of this enzyme which have emerged to be considered as a drug target for the ...
S. Sushanth Kumar +3 more
semanticscholar +1 more source
A green synthesis of isatoic anhydrides from isatins with urea–hydrogen peroxide complex and ultrasound [PDF]
, 2007 The oxidation of isatins at room temperature, using the cheap and environmentally friendly urea-hydrogen peroxide complex and ultrasonic irradiation, has been investigated. The ultrasonic irradiation dramatically reduces the reaction time.
Todor Deligeorgiev +3 more
openalex +5 more sources
Estimation of isatin in spiked plasma samples using high performance liquid chromatography [PDF]
Chemical Industry and Chemical Engineering Quarterly, 2013 An isocratic analytical method based on liquid chromatographic determination with UV detection is described for the determination of isatin in spiked plasma and in its synthetic mixture.
Alothman Zeid A. +2 more
doaj +1 more source
Berichte der deutschen chemischen Gesellschaft, 1879 n ...
Claisen, L., Shadwell, J.
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Isatin Bis-Indole and Bis-Imidazothiazole Hybrids: Synthesis and Antimicrobial Activity
Molecules, 2022 Isatin and its derivatives are important heterocycles found in nature and present in numerous bioactive compounds which possess various biological activities. Moreover, it is an essential building block in organic synthesis.
F. Bonvicini +4 more
semanticscholar +1 more source
Synthesis of substituted isatins [PDF]
Tetrahedron Letters, 2013 AbstractAcid‐promoted cyclization of alkoximinoacetanilides is developed to provide a convenient synthesis of a broad spectrum of isatins bearing lipophilic substituents.
Michael D. Tufano, Larry L. Klein
openaire +4 more sources
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 Joining the global fight against Tuberculosis, the world's most deadly infectious disease, herein we present the design and synthesis of novel isatin-nicotinohydrazide hybrids (5a–m and 9a–c) as promising anti-tubercular and antibacterial agents.
Zainab M. Elsayed +8 more
semanticscholar +1 more source
Imide and isatin derivatives as β-lactam mimics of β-lactam antibiotics [PDF]
, 2002 Activated γ-lactams, which are derivatives of succinimide, phthalimide and isatin with suitable elements of molecular recognition, have been synthesised as mimics of the ß-lactam antibiotics and their chemical and biological reactivity ...
Casey, Lorraine A. +4 more
core +1 more source
5-(Trifluoromethoxy)isatin [PDF]
Acta Crystallographica Section E Structure Reports Online, 2012 THE TITLE COMPOUND [SYSTEMATIC NAME: 5-(trifluoro-meth-oxy)-1H-indole-2,3-dione], C9H4F3NO3, crystallized with two mol-ecules in the asymmetric unit. Inter-molecular N-H⋯O hydrogen bonds link the mol-ecules to form layers parallel to the ab plane. In addition, π-π stacking inter-actions are observed with a centroid-centroid distance of 3.721 (1) Å. The
Andreas Roodt +3 more
openaire +4 more sources
Life Sciences, 2016 There has been growing interest in the synthesis of new derivatives from isatin, found in Isatis genus. Our objectives were to characterize the antinociceptive mechanism of action of isatin, N-methyl-isatin (MI) and N-methyl-3-(2-oxopropyl)-3-hydroxy-2-oxindole (MOI).Substances (0.1-10mg/kg, p.o.) were studied in chemical (paw licking induced by ...
Thais Biondino Sardella Giorno +3 more
openaire +3 more sources