Modification of polymer backbone via halogenation and comonomer selection leads to conjugated backbones of different stereoelectronic properties, thin film morphologies, and electrical characteristics. The interplay of conformational isomerism, coplanarity, backbone curvature, backbone orientation, and ordering in thin films, electrical conductivity ...
Diego R. Hinojosa+11 more
wiley +1 more source
Hydrazones as Singular Reagents in Asymmetric Organocatalysis [PDF]
This Minireview summarizes strategies and developments regarding the use of hydrazones as reagents in asymmetric organocatalysis, their distinct roles in nucleophile–electrophile, cycloaddition, and cyclization reactions.
Fernández Fernández, Rosario Fátima+4 more
core +1 more source
Chlorination of isatins with trichloroisocyanuric acid [PDF]
Isatin and its derivatives have been extensively reported in the literature as having range of potential pharmacological compounds. The Sandmeyer method is the most widely used for isatin synthesis and furnishes different substituted isatins, usually with high yields.
Silva, Bárbara V+2 more
openaire +4 more sources
Recent Advances in Isatin–Thiazole Hybrids: Synthesis, Structural Design, and Biological Application
ABSTRACT Isatin–thiazole hybrids are considered privileged chemical scaffolds due to their broad spectrum of pharmacological properties, making them attractive candidates for drug development. As a result, isatin–thiazole derivatives have emerged as a prominent class of hybrid heterocycles and have been the focus of extensive research in recent years ...
Isadora M. G. Andrade+4 more
wiley +1 more source
1-Tetradecylindoline-2,3-dione
In the title N-alkyl isatin, C22H33NO2, the isatin moiety is planar (r.m.s. deviation = 0.03 Å). The tetradecyl substituent has all torsion angles in an antiperiplanar conformation.
Khalil Mamari+3 more
doaj +1 more source
(E)-3-Heteroarylidenechroman-4-ones as potent and selective monoamine oxidase-B inhibitors [PDF]
A series of (E)-3-heteroarylidenechroman-4-ones (1a-r) was designed, synthesized and investigated in vitro for their ability to inhibit the enzymatic activity of both human monoamine oxidase (hMAO) isoforms, hMAO-A and hMAO-B.
Alcaro, Stefano+6 more
core +1 more source
Dimethyl Fumarate Alleviates Dextran Sulfate Sodium-Induced Colitis, through the Activation of Nrf2-Mediated Antioxidant and Anti-inflammatory Pathways. [PDF]
Oxidative stress and chronic inflammation play critical roles in the pathogenesis of ulcerative colitis (UC) and inflammatory bowel diseases (IBD). A previous study has demonstrated that dimethyl fumarate (DMF) protects mice from dextran sulfate sodium ...
Farzaneh, Ted+8 more
core +2 more sources
Advances in Enaminomaleimides Chemistry: Synthesis, Chemical Applications, and Perspectives
Enaminomaleimides are versatile building blocks for the construction of functionalized heterocycles. Their unique nucleophilic character, contrasting with the classical electrophilic nature of maleimides, enables diverse synthetic applications, showing promising potential in both materials science and medicinal chemistry.
Adrián López‐Francés+5 more
wiley +1 more source
An update on the synthesis and reactivity of spiro-fused β-lactams [PDF]
Beta-Lactam ring-containing compounds play a pivotal role in drug design and synthetic chemistry. Spirocyclic beta-lactams, representing an important beta-lactam subclass, have recently attracted considerable interest with respect to new synthetic ...
D'hooghe, Matthias, Dao Thi, Hang
core +1 more source
A Bis‐Thiosemicarbazone Pd(II) SiO2 Nanoparticle Conjugate for CC Coupling Catalysis
The thiosemicarbazone (TSC) Pd complex–SiO2 nanoparticle conjugate [PdL]–APTES–SiO2 (APTES = (3‐aminopropyl)triethoxysilane) was synthesized through covalent binding of the pentadentate bis(N4‐(2‐ethylphenyl)) 2,6‐diacetyl‐pyridine TSC onto monodispersed SiO2, followed by coordination of Pd(II) and used as precatalysts in Suzuki–Miyaura‐type cross ...
Eric Tobechukwu Anthony+5 more
wiley +1 more source