Results 51 to 60 of about 17,152 (250)

Recent advances in isatin-derived hybrids: promising multifunctional agents for drug development [PDF]

Makedonsko Farmacevtski Bilten
Isatin-based hybrids have emerged as promising candidates in medicinal chemistry due to their broad biological activities and structural versatility. This review outlines recent developments (2020–2025) in the design of isatin hybrids targeting cancer ...
Aleksandar Dimkovski, Evgenija Mihajloska, Ana Poceva Panovska   +2 more
doaj   +1 more source

(E)-3-Heteroarylidenechroman-4-ones as potent and selective monoamine oxidase-B inhibitors [PDF]

, 2016
A series of (E)-3-heteroarylidenechroman-4-ones (1a-r) was designed, synthesized and investigated in vitro for their ability to inhibit the enzymatic activity of both human monoamine oxidase (hMAO) isoforms, hMAO-A and hMAO-B.
Alcaro, Stefano, BIAVA, Mariangela, DESIDERI, Nicoletta, FIORAVANTI, Rossella, Ortuso, Francesco, PROIETTI MONACO, LUCA, Yáñez, Matilde   +6 more
core   +1 more source

1-Tetradecylindoline-2,3-dione

Acta Crystallographica Section E, 2010
In the title N-alkyl isatin, C22H33NO2, the isatin moiety is planar (r.m.s. deviation = 0.03 Å). The tetradecyl substituent has all torsion angles in an antiperiplanar conformation.
Khalil Mamari, Hafid Zouihri, El Mokhtar Essassi, Seik Weng Ng   +3 more
doaj   +1 more source

Effective Low‐Temperature Oxidative Denitrogenation With Sulfated Titania Supported on Porous Carbon

Small Structures, Volume 7, Issue 1, January 2026.
We report the first synthesis of the novel S‐TiO2/C catalyst on highly porous pANI‐derived carbon. It achieved outstanding oxidative denitrogenation (ODN) performance, completing conversion of 1000 ppm indole in 60 min at 45°C. This is due to well‐dispersed S‐TiO2 facilitating H2O2 activation and •OH radical generation, and it proved highly reusable ...
Imteaz Ahmed, Minyoung Yoon, Sung Hwa Jhung   +2 more
wiley   +1 more source

Facile synthesis of Schiff and Mannich bases of isatin derivatives [PDF]

, 2015
We report herein on the synthesis of some isatin Schiff’s bases (1–11), which were prepared from the reaction of isatin and some aromatic amines. These in turn were converted to the corresponding Mannich bases (12-23) by reaction with a number of ...
Al-azzawi, Nuhad K. E., Al-kadhimi, Ahmed A. H., Khalaf, Abedawn I.   +2 more
core  

Syntheses and Characterizations of Some New N-alkyl, Isoxazole and Dioxazole Derivatives of 5-Chloroisatin [PDF]

, 2017
N-alkyl and cycloadducts derivatives of 5-Chloroisatin were synthesized in good to excellent yields. The method evidences a selective N-alkylation when using 1,2-bis (2-chloroethoxy) ethane as efficient spacer at room temperature on the 5-Chloroisatin ...
Rodi, Y. K. (Y), Senhaji, O. (O), Skalli, M. K. (M), Tribak, Z. (Z)   +3 more
core   +1 more source

Discovery of Some New Heterocyclic Systems from Carbene‐Based Reactions of Indigo and N‐Methyl Derivatives

European Journal of Organic Chemistry, Volume 28, Issue 46, December 12, 2025.
Accessing new heterocyclic structural space on exposure of indigo‐based substrates to carbene or carbenoid reactive intermediates is the key focus of this work. A number of unprecedented heterocyclic products have been discovered and their structures characterized.
Sarfaraz Ali Ghumro, Matthew J. Perry, Christopher Richardson, Stephen G. Pyne, John B. Bremner, Paul A. Keller   +5 more
wiley   +1 more source

Textile technology in Nepal in the 5th-7th centuries CE: the case of Samdzong [PDF]

, 2016
The first results of textile and dye analyses of cloth remains recovered in Samdzong, Upper Mustang, Nepal, are presented. The site consists of ten shaft tombs, dated between the 400-650 CE, cut into a high cliff face at an elevation of 4000 m asl.
Aldenderfer, M, Gleba, M, Vanden Berghe, I   +2 more
core   +2 more sources

Synthesis and Application of Bioactive N‐Functionalized Aziridines

Angewandte Chemie, Volume 137, Issue 44, October 27, 2025.
This review discusses modern synthetic methods for the preparation of aziridine‐containing small molecules, including biocatalytic, electrocatalytic, and photocatalytic strategies. We highlight the compatibility of various synthetic methods with control of the exocyclic N‐substituent.
Hao Tan, Samya Samanta, Nan Qiu, Alexander Adibekian, David C. Powers   +4 more
wiley   +2 more sources

Pseudomonas aeruginosa Expresses a Functional Human Natriuretic Peptide Receptor Ortholog: Involvement in Biofilm Formation [PDF]

, 2016
This is the final version of the article. Available from the publisher via the DOI in this record.Considerable evidence exists that bacteria detect eukaryotic communication molecules and modify their virulence accordingly.
Bazire, A, Blier, AS, Boireau, W, Bouffartigues, E, Clamens, T, Diaz, S, Dufour, A, Feuilloley, MG, Harmer, NJ, Hoffmann, B, Hulen, C, Lesouhaitier, O, Mijouin, L, Rosay, T, Sergent, JA, Vieillard, J   +15 more
core   +1 more source