Results 51 to 60 of about 9,186 (209)

Iodine-catalyzed Synthesis, Antibacterial, and Antioxidant Activity of Isatin Derivatives

Indonesian Journal of Chemistry
Isatin is a unique compound with many bioactivities such as antiviral, anti-HIV, antitumor, anti-inflammatory, anticonvulsant, and antifungal. In this study, isatin derivatives were synthesized with an iodine catalyst and tested for antibacterial and ...
Antonius Herry Cahyana, Agus Rimus Liandi, Yosua Ongkowidjawa   +2 more
doaj   +1 more source

Condensation of Indole with Isatin over AlCl₃/Mesoporous Aluminosilicate

Indonesian Journal of Chemistry, 2015
Aluminium chloride immobilized on mesoporous aluminosilicate was investigated as catalysts in the condensation of isatin with indole. AlCl3/mesoporous aluminosilicate (AlCl3/AM) catalysts were prepared by impregnation of 1, 5, 10 and 15 wt% AlCl3 on the ...
Tri Esti Purbaningtias, Didik Prasetyoko, Hasliza Bahruji, Yusuf Muhammad Zein, Sugeng Triwahyono, Arief Fadlan, Imroatul Qoniah   +6 more
doaj   +1 more source

New s‐Triazine–Hydrazone Hybrids Targeting EGFR: Design and Anticancer Activity Against A549 Lung Adenocarcinoma

Journal of Chemistry, Volume 2026, Issue 1, 2026.
A new series of pyridine–s‐triazine–hydrazone derivatives was designed, synthesized via an efficient two‐step route, and fully characterized by 1H‐NMR, 13C‐NMR, and elemental analyses. The compounds were evaluated for antiproliferative activity against A549 lung cancer cells and cytotoxicity toward WI‐38 fibroblasts.
Hessa H. Al-Rasheed, Sarah A. Al-Khamis, Assem Barakat, Aliaa A. Masoud, Ahmed A. Sobhy, Maha El Demellawy, Doaa A. Ghareeb, Anamika Sharma, Beatriz G. de la Torre, Fernando Albericio, Ayman El-Faham, Sohini Basu Roy   +11 more
wiley   +1 more source

1-Benzyl-5-methylindoline-2,3-dione

IUCrData, 2016
The title compound, C16H13NO2, is an isatin (indole-2,3-dione) derivative. The isatin moiety is almost planar with an r.m.s. deviation of 0.022 Å, and its mean plane makes a dihedral angle of 74.19 (12)° with the benzyl ring.
N. Sharmila, T. V. Sundar, G. Satish, P. Venkatesan   +3 more
doaj   +1 more source

Development of novel benzofuran-isatin conjugates as potential antiproliferative agents with apoptosis inducing mechanism in Colon cancer [PDF]

, 2021
Wagdy M. Eldehna, Rofaida Salem, Zainab M. Elsayed, Tarfah Al‐Warhi, Hamada R. Knany, Rezk R. Ayyad, Thamer Bin Traiki, Maha‐Hamadien Abdulla, Rehan Ahmad, Hatem A. Abdel‐Aziz, Radwan El‐Haggar   +10 more
openalex   +1 more source

Discovery of Some New Heterocyclic Systems from Carbene‐Based Reactions of Indigo and N‐Methyl Derivatives

European Journal of Organic Chemistry, Volume 28, Issue 46, December 12, 2025.
Accessing new heterocyclic structural space on exposure of indigo‐based substrates to carbene or carbenoid reactive intermediates is the key focus of this work. A number of unprecedented heterocyclic products have been discovered and their structures characterized.
Sarfaraz Ali Ghumro, Matthew J. Perry, Christopher Richardson, Stephen G. Pyne, John B. Bremner, Paul A. Keller   +5 more
wiley   +1 more source

Síntese e caracterização estrutural do ligante isatina-3-(N4-benziltiossemicarbazona) e do seu complexo de mercúrio(II) Synthesis and structural characterization of the ligand isatin-3-(N4-benzylthiosemicarbazone) and its mercury(II) complex

Química Nova, 2010
The reaction of 4-(phenyl)thiosemicarbazide with isatin yielded a new ligand, isatin-3-(N4-benzylthiosemicarbazone). Isatin-3-(N4-benzylthiosemicarbazone) deprotonated in ethanol/KOH reacts with an ethanolic solution of Hg(NO3)2 to give a mercury complex.
Alexandra de Souza Fonseca, Gisele Louro Peres, Tomás Garcia Storino, Leandro Bresolin, Vanessa Santana Carratu, Vinícius F. Giglio, Estela dos Reis Crespan, Manfredo Hörner   +7 more
doaj   +1 more source

Next‐Generation Proteolysis‐Targeting Chimeras in Precision Oncology: Multifunctional Designs, Emerging Modalities, and Translational Prospects in Targeted Protein Degradation

Drug Development Research, Volume 86, Issue 8, December 2025.
ABSTRACT Proteolysis‐targeting chimeras (PROTACs)‐mediated protein degradation has been recently developed as a game‐changing approach in oncology drug development. It represents a paradigm shift from traditional enzyme inhibition to selective protein degradation.
Mohamed S. Nafie, Mohamed K. Diab, Asmaa S. A. Yassen, Amany M. Elshamy, Mohamed R. El Tohamy, Haytham O. Tawfik, Sherif Ashraf Fahmy   +6 more
wiley   +1 more source

Isatin-Derived Compounds as Carbon Steel Corrosion Inhibitors in Highly Saline Media

International Journal of Electrochemical Science, 2013
Carbon steel corrosion in CO2-saturated solutions, simulating the produced water generated in oil and gas extraction, was investigated using weight loss, electrochemical measurements and surface characterization. The effectiveness of two isatin compounds,
A.B. da Silva, J.A.C.P. Gomes, E. D’Elia, M.J.C. Rezende, A.C. Pinto, B.N.M. Silva, B.V. Silva   +6 more
doaj   +1 more source

Synthesis of Poly(p‐Terphenyl N,N‐Dimethylpiperidinium)s Using Asymmetric Ketone‐Based Branching Agent

Macromolecular Materials and Engineering, Volume 310, Issue 12, December 2025.
4‐Biphenylyl trifluoromethyl ketone is used as an asymmetric branching agent in the synthesis of aryl ether‐free poly(p‐terphenyl‐N,N‐dimethylpiperidinium)s via optimized superacid‐catalyzed Friedel‐Crafts polyhydroxyalkylation. The resulting quaternized polymers, with varying branching degrees, show high molecular weights (∼70 kDa) as determined by ...
Ihor Tkachenko, Tetiana Samoilenko, Mariana Gumenna, David Kalabis, Ruslan Kravchuk, Vassili Nazarenko, Iva Matolínová, Valery Shevchenko   +7 more
wiley   +1 more source