Results 81 to 90 of about 17,152 (250)

Synthesis, Antimicrobial, and Anticancer Activities of Novel Nitrofuran Derivatives

Journal of Chemistry, 2023
Keeping in view the varying therapeutic attributes of 5-nitrofuran and isatin derivatives, novel 5-nitrofuran‒isatin molecular hybrids (2, 5–7) were synthesized by standard protocols, characterized by various spectroscopic techniques, and eventually ...
Malik Suliman Mohamed, Khaled M. Elamin, Rawaf Alenazy, Eyman Mohamed Eltayib, Mona Timan Idriss, Noura A. A. Alhudaib, Tilal Elsaman, Magdi Awadalla Mohamed   +7 more
doaj   +1 more source

Cannabinoid CB2 receptor‐mediated analgesia: mechanism‐based insights and therapeutic potential

British Journal of Pharmacology, Volume 182, Issue 21, Page 5090-5118, November 2025.
Agonists of the cannabinoid 2 (CB2) receptor have shown promise for the treatment of pain in a variety of animal models. However, despite current preclinical evidence supporting the use of CB2 agonists for pain, successful translation of findings from preclinical models to human patients is lacking.
Kelsey G. Guenther, Andrea G. Hohmann
wiley   +1 more source

Organocatalytic Enantioselective Friedel-Crafts Aminoalkylation of Indoles in the Carbocyclic Ring [PDF]

, 2016
The first general catalytic method for the, so far elusive, enantioselective Friedel−Crafts functionalization of indoles in the carbocyclic ring is presented.
Blay Llinares, Gonzalo, Fernández Picot, Isabel, Montesinos Magraner, Marc, Muñoz, M. Carmen, Pedro, José Ramón, Rendón-Patiño, Alejandra, Vila Descals, Carlos   +6 more
core   +6 more sources

Natural variation of the wheat root exudate metabolome and its influence on biological nitrification inhibition activity

Plant Biotechnology Journal, Volume 23, Issue 11, Page 4755-4772, November 2025.
Summary Excessive nitrogen use and low nitrogen use efficiency (NUE) in current agroecosystems are disrupting the global nitrogen cycle. Chemical inhibitors offer only temporary relief, while plant‐derived biological nitrification inhibitors (BNIs) remain safer but underexplored.
Arindam Ghatak, Alexandros E. Kanellopoulos, Cristina López‐Hidalgo, Andrea Malits, Yuhang Meng, Florian Schindler, Shuang Zhang, Jiahang Li, Steffen Waldherr, Hugo Ribeiro, Melina Kerou, Logan H. Hodgskiss, Maximilian Dreer, Reyazul Rouf Mir, Sandeep Sharma, Gert Bachmann, Dimitrios G. Karpouzas, Christa Schleper, Evangelia S. Papadopoulou, Palak Chaturvedi, Wolfram Weckwerth   +20 more
wiley   +1 more source

Daganatos sejtek rezisztenciáját gátló vegyületek fejlesztése = Development of compounds targeting multidrug resistant cancer [PDF]

, 2009
A korszerű daganatellenes terápia jelentős sikerei ellenére a kemoterápiával szemben fellépő rezisztencia (multidrog rezisztencia, MDR) továbbra is megoldásra váró klinikai kihívás.
Szakács, Gergely
core  

Development of Synergetic Combinations of a Novel Apoptosis Inducer with AKT and Hsp90 Selective Inhibitors Targeting Hormone-Sensitive and Hormone-Resistant Breast Cancer Cells

Proceedings
Introduction: The design and development of antitumor compounds based on an isatin core led to the synthesis of 1-substituted isatin-5-sulfonamides with potent antiproliferative activity [...]
Diana I. Salnikova, Stepan K. Krymov, Danila V. Sorokin, Fedor B. Bogdanov, Olga E. Andreeva, Alvina I. Khamidullina, Andrey E. Shchekotikhin, Alexander M. Scherbakov   +7 more
doaj   +1 more source

Multistep Reactions Initiated by Amine‐Based Organometallic Methods

European Journal of Organic Chemistry, Volume 28, Issue 40, October 29, 2025.
The advent of C–H activation and other organometallic methodologies making use of transient directing groups or free amines themselves for the elaboration of amine substrates provides unique access to cascade‐type reactions that can generate significant molecular complexity in one pot. The pursuit of atom‐ and step‐economical pathways to access complex
Victoria D. Ho, Olutayo N. Farinde, Kendra K. Shrestha, Michael C. Young   +3 more
wiley   +1 more source

A Modified Indigo Method for the Determination of Ozone in Nonaqueous Solvents [PDF]

, 2013
The indigo method for the analysis of aqueous ozone was modified to allow analysis of dissolved ozone in nonaqueous liquid phases. The method was tested using the solvent decamethylcyclopentasiloxane 245 and a vegetable oil. The molar absorptivity at 600
Chedly Tizaoui
core   +1 more source

A green synthesis of isatoic anhydrides from isatins with urea-hydrogen peroxide complex and ultrasound [PDF]

, 2007
The oxidation of isatins at room temperature, using the cheap and environmentally friendly urea-hydrogen peroxide complex and ultrasonic irradiation, has been investigated. The ultrasonic irradiation dramatically reduces the reaction time.
Deligeorgiev, Todor, Vaquero López, Juan José, Vasilev, Aleksey, Álvarez-Builla Gómez, Julio   +3 more
core   +2 more sources