Results 201 to 210 of about 184,947,225 (237)

Enoxaparin Does Not Ameliorate Limb Ischemia-Reperfusion Injury

Journal of Surgical Research, 2008
Since low molecular weight heparin has greater bioavailability and sustained serum levels in vivo than unfractionated heparin, it has been used to supplant unfractionated heparin to achieve therapeutic anticoagulation in humans. These studies were designed to determine whether treatment with enoxaparin could protect murine skeletal muscle from ischemia
Thomas A, Abbruzzese, Hassan, Albadawi, Jeanwan, Kang, Virendra I, Patel, Jin-Hyung, Yoo, Glenn M, Lamuraglia, Michael T, Watkins   +6 more
openaire   +2 more sources

Assessment of microvascular dysfunction in acute limb ischemia‐reperfusion injury

Journal of Magnetic Resonance Imaging, 2018
Background Ischemia‐reperfusion (I/R) injury involves damage to the microvessel structure (eg, increased permeability) and function (blunted vasomodulation). While microstructural damage can be detected with dynamic contrast‐enhanced (DCE) MRI, there is no diagnostic to detect deficits in microvascular function.
Ganesh, Tameshwar, Zakher, Eric, Estrada, Marvin, Cheng, Hai-Ling Margaret   +3 more
openaire   +3 more sources

Basic Control of Reperfusion Effectively Protects Against Reperfusion Injury in a Realistic Rodent Model of Acute Limb Ischemia

Circulation, 2008
BACKGROUND: Reperfusion injury is insufficiently addressed in current clinical management of acute limb ischemia. Controlled reperfusion carries an enormous clinical potential and was tested in a new reality-driven rodent model.
Hendrik T Tevaearai Stahel, Jian-Hui Li, Florian Dick   +2 more
exaly   +2 more sources

Cepharanthine mitigates lung injury in lower limb ischemia–reperfusion

Journal of Surgical Research, 2015
Oxidation and inflammation caused by lower limb ischemia-reperfusion (I/R) readily induce lung injury. We elucidated whether cepharanthine, a potent antioxidative and anti-inflammatory drug, can mitigate lung injury induced by lower limb I/R. Role of heme oxygenase 1 (HO-1) was also investigated.Adult male Sprague-Dawley rats were randomized to receive
Ming-Chang, Kao, Chen-Hsien, Yang, Wei-Chih, Chou, Joen-Rong, Sheu, Chun-Jen, Huang   +4 more
openaire   +2 more sources

The protective efficacy of magnolol in hind limb ischemia-reperfusion injury

Phytomedicine, 2009
We investigated the protective effects of magnolol, an active antioxidant and free radical scavenger extracted from Magnolia officinalis, in a hind limb ischemic-reperfusion animal model. Adult male Sprague-Dawley rats were subjected to hind limb ischemic insult for 2 hours and were intravenously treated with magnolol at 0.01 mg/kg (n=8), 0.3 mg/kg (n ...
Hung-Yi Chena, Yu-Chang Hung, E-Jian Leea, Tsung-Ying Chen, I-Chuan Chuang, Tian-Shung Wu   +5 more
openaire   +3 more sources

A noninvasive murine model of hind limb ischemia-reperfusion injury

Journal of Surgical Research, 2004
This study describes a novel murine method of the Controlled Tension Tourniquet (CTT). The CTT applies a measured circumferential tension to hind limbs using a tourniquet attached to digital strain gauges, and is useful for investigating hind limb ischemia reperfusion (IR).Mice were subjected to 1, 3, or 6 h of unilateral hind limb ischemia followed by
James A, Bonheur, Hassan, Albadawi, George M, Patton, Michael T, Watkins   +3 more
openaire   +2 more sources

Limb ischemia–reperfusion differentially affects the periosteal and synovial microcirculation

Journal of Surgical Research, 2012
Joints are privileged compartments that enjoy increased protection against the inflammatory reactions affecting the extremities. We hypothesized that the functional characteristics of the microvasculature would contribute to the differential defensive potential of the synovial membrane.We investigated the synovial microcirculatory reactions and ...
Petra, Hartmann, Gábor, Erős, Renáta, Varga, József, Kaszaki, Dénes, Garab, István, Németh, Zsolt, Rázga, Mihály, Boros, Andrea, Szabó   +8 more
openaire   +2 more sources

Limb ischemic postconditioning protects myocardium from ischemia-reperfusion injury

Scandinavian Cardiovascular Journal, 2006
To test the hypothesis that limb ischemic postconditioning protects the myocardium from reperfusion injury, and examine the mechanism involved.Forty rabbits were randomly divided into four groups: Control, Ischemic Preconditioning, Ischemic Postconditioning and Remote Postconditioning.
Chun-Mei, Li, Xing-Hua, Zhang, Xiao-Jing, Ma, Man, Luo   +3 more
openaire   +2 more sources

Strategies to Reduce Ischemia Reperfusion Injury in Vascularized Composite Allotransplantation of the Limb

The Journal of Hand Surgery, 2017
An important and often underinvestigated contributor to solid organ transplant rejection is ischemia reperfusion injury. This pathophysiological response releases damaging reactive oxygen species and cell stress signals that initiate inflammation, which has a critical role in priming the immune system for allorecognition.
Kavit R, Amin, Jason K F, Wong, James E, Fildes   +2 more
openaire   +2 more sources

Protective Effect of Hydrogen Gas on Mouse Hind Limb Ischemia-Reperfusion Injury

Journal of Surgical Research, 2021
The aim of this study was to investigate the mechanism of hydrogen gas on hind limb IR injury.Male C57BL/6 mice were randomly divided into three groups: sham group (Sham), ischemia-reperfusion group (IR), IR plus H2 inhalation group (IR + H2). IR was induced by interrupting hind limb blood flow for 3h, followed by 4h of reperfusion, and H2 was ...
Jian Tong, Yu Zhang, Pan Yu, Jie Liu, XiaoLiang Mei, Jia Meng   +5 more
openaire   +2 more sources