Results 131 to 140 of about 3,281 (176)

Survival Kinases in Ischemic Preconditioning and Postconditioning. [PDF]

Cardiovascular Research, 2006
Despite nearly twenty years of research into the field of ischemic preconditioning, the actual mechanism of protection remains unclear. However, much progress has been made in elucidating the signal transduction pathways that convey the extracellular signal initiated by the preconditioning stimulus to the intracellular targets of cardioprotection, with
Derek Hausenloy
exaly   +3 more sources

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Postconditioning and Remote Postconditioning of Ischemic Rat Cardiac Grafts

European Surgical Research, 2010
<i>Background:</i> Global warm ischemia of transplanted cardiac grafts is associated with apoptosis and subsequent tissue necrosis. It is suggested that postconditioning (PostC) may ameliorate the early outcome of cardiac grafts after ischemia-reperfusion.
Y, Tang, A, Mennander, N, Oksala, M, Atalay, H, Syvala, A, Lagerstedt, M, Kuuslahti, R, Nieminen, N, Anas, E, Moilanen, M, Tarkka   +10 more
openaire   +2 more sources

Connexin 43 in ischemic pre- and postconditioning

Heart Failure Reviews, 2007
Connexin 43 (Cx43) is the predominant protein forming gap junctions and non-junctional hemichannels in ventricular myocardium, but Cx43 is also localized at the inner membrane of cardiomyocyte mitochondria. In cardiomyocytes, Cx43 is involved in the formation of reactive oxygen species, which are central to the signal transduction cascade of ischemic ...
Rainer, Schulz, Kerstin, Boengler, Andreas, Totzeck, Yukun, Luo, David, Garcia-Dorado, Gerd, Heusch   +5 more
openaire   +2 more sources

Ischemic Postconditioning: Not Giving Up Yet

Catheterization and Cardiovascular Interventions, 2016
Key Points Ischemic postconditioning protects against reperfusion injury. Adjunctive use of manual thrombus aspiration improves reperfusion results in patients undergoing primary angioplasty. Combining both strategies (ischemic postconditioning and thrombus aspiration) may have additive effects in terms of myocardial salvage. The PORT trial will study
Jorge A, Belardi, Mariano, Albertal
openaire   +2 more sources

Ischemic Postconditioning Prevents Ischemic Acute Renal Failure

Transplantation Proceedings, 2007
Delayed graft function (DGF), a frequent complication after kidney transplantation, decreases graft survival. Ischemia/reperfusion (I/R) injuries play a major role in DGF pathophysiology. Because ischemic postconditioning (IP) is efficient to prevent myocardial I/R injuries and reduce infarct size, we sought to describe renal effects of IP.Swiss mice ...
I, Szwarc, S, Soullier, N, Gayrard, C, Mejean, G, Mourad, A, Argiles   +5 more
openaire   +2 more sources

Cerebral mechanisms of hypoxic/ischemic postconditioning

Biochemistry (Moscow), 2017
This review analyzes recent data on mechanisms of cerebral hypoxia and the protective methods of hypoxic and ischemic postconditioning, as well as their interrelationship with the key mechanisms responsible for neuroprotection and neuroplasticity.
O V, Vetrovoy, E A, Rybnikova, M O, Samoilov   +2 more
openaire   +2 more sources

Mitochondrial Injury and Protection in Ischemic Pre- and Postconditioning

Antioxidants & Redox Signaling, 2011
Mitochondrial damage is a determining factor in causing loss of cardiomyocyte function and viability, yet a mild degree of mitochondrial dysfunction appears to underlie cardioprotection against injury caused by postischemic reperfusion. This review is focused on two major mechanisms of mitochondrial dysfunction, namely, oxidative stress and opening of ...
Di Lisa, Fabio, Canton, Marcella, Carpi, Andrea, Kaludercic, Nina, Menabò, Roberta, Menazza, Sara, Semenzato, Martina   +6 more
openaire   +2 more sources

The Phenomenon of Ischemic Postconditioning of the Heart

Neuroscience and Behavioral Physiology, 2014
This review analyzes reports on the question of ischemic postconditioning of the heart. The review shows that postconditioning decreases infarct size, prevents cardiomyocyte apoptosis, improves cardiac contractility during the reperfusion period, increases the tolerance of the heart to the arrhythmogenic action of reperfusion, prevents invasion of ...
L. N. Maslov, A. G. Mrochek, L. Hanus, J.-M. Pei, Y. Zhang, H. Wang, N. V. Naryzhnaya   +6 more
openaire   +1 more source

Determining the optimal time to introduce ischemic postconditioning

Expert Review of Cardiovascular Therapy, 2011
ST-segment elevation myocardial infarction (STEMI) is a major cause of death and heart failure in Western society [1].
Lønborg, Jacob, Engstrøm, Thomas
openaire   +3 more sources

Hes1 is upregulated by ischemic postconditioning and contributes to cardioprotection

Cell Biochemistry and Function, 2014
The expression of Hes1 is increased following myocardial infarct and other ischemic cardiomyopathies, but the role of Hes1 in cardioprotection provided by ischemic postconditioning (IPost) remains unclear. In this study, we used gain and loss of function approaches to investigate the role of Hes1 in cardioprotection during IPost.
Xue-liang, Zhou, Yong, Zhao, Yi-hu, Fang, Qi-rong, Xu, Ji-chun, Liu   +4 more
openaire   +2 more sources