Results 151 to 160 of about 47,870 (244)

miR‐9 Restricts Insulin Secretion by Targeting Rab34, Which Mediates Lysosomal Degradation of Proinsulin

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Insulin secretion is a complex, vesicular transport process. Rab34 is a key regulator of intracellular vesicle transport; however, its role in insulin secretion has not yet been reported. miRNA‐9 is vital for the development and progression of the diagnosis and treatment of type 2 diabetes. This study aimed to investigate whether miR‐9 targets
Zhen‐Zhen Guo, Ao‐Ying Li, Ting‐Ting Xiang, Zu‐Hao Zhang, Ao Deng, Yang Han   +5 more
wiley   +1 more source

Proteoforms in Disease: Biomedical Applications of Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The proteome is a dynamic landscape of proteoforms arising from genetic mutations, alternative splicing, and post‐translational modifications (PTMs), which collectively drive biological function and disease phenotypes. Mass spectrometry (MS)‐based proteomics has emerged as an essential technique for elucidating this molecular complexity ...
Holden T. Rogers, Zachery R. Gregorich, Megan S. Gant, Zhan Gao, Julia Chamot‐Rooke, Ying Ge   +5 more
wiley   +1 more source

Parkinson's Disease and Retinal Age Gap: A Cross‐Sectional Analysis

Movement Disorders, EarlyView.
Abstract Background Deep‐learning models are capable of predicting age from retinal scans and the difference between this and chronological age, retinal age gap, has been shown to be significantly associated with risk of mortality, cardiovascular diseases, and kidney failure.
Akshay Narayan, Oscar Earle, Yukun Zhou, Axel Petzold, Rimona S. Weil, Alastair K. Denniston, Anthony P. Khawaja, Pearse A. Keane, Zhuoting Zhu, Siegfried K. Wagner   +9 more
wiley   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Bone Adaptation and Labor Organization in Co‐Located Medieval Anatolian Populations

International Journal of Osteoarchaeology, EarlyView.
ABSTRACT Skeletal evidence from geographically co‐located populations offers a rare opportunity to disentangle subsistence‐driven bone adaptation from socially organized labor. This study examines upper limb morphology in two Byzantine communities—the urban center of Tyana (10th–13th c.
Gökhan Çakan, Ahmet G. Erdemir, Adalet E. Yıldız, Üstün Aydıngöz, Osman Doğanay, Ömür Dilek Erdal   +5 more
wiley   +1 more source

Globally widespread weeds show preadaptation to non‐analogue climates: a common garden approach

Oikos, EarlyView.
Climatic niche shifts have been documented for plant species introduced into new regions, however the underlying mechanisms are poorly understood. Niche shifts into novel climates are particularly difficult to predict as previous occurrence data cannot reveal whether these novel climates are within species' fundamental niche limits.
Thomas Frank Carlin, Jennifer L. Bufford, Philip E. Hulme, William K. Godsoe   +3 more
wiley   +1 more source

Experimental and field evidence indicate that islet‐nesting tundra birds experience reduced nest predation and benefit indirectly from high snow goose densities

Oikos, EarlyView.
Landscape features can shape the occurrence and strength of predator–prey interactions by influencing predation risk and prey distribution. In the High Arctic, some bird species select nesting sites with physical features that impede access for their main terrestrial predator, the Arctic fox.
Marylou Beaudoin, Andréanne Beardsell, Éliane Duchesne, Madeleine‐Zoé Corbeil‐Robitaille, Pierre Legagneux, Dominique Berteaux, Joël Bêty   +6 more
wiley   +1 more source

Exploring the Reproductive Toxicity of Bisphenol S Through a Network Toxicology and Molecular Docking Analysis

Pediatric Discovery, EarlyView.
Utilizing network toxicology, molecular docking, and dynamic simulations to investigate the potential reproductive toxicity of bisphenol S (BPS). ABSTRACT The aim of this study was to investigate the potential reproductive toxicity of bisphenol S (BPS) and the related molecular mechanisms through a network toxicology approach.
Siyuan Wang, Yan Fu, Xu Huang, Qitong Guo, Xiangqin Zheng, Shengde Wu, Lianju Shen, Guanghui Wei   +7 more
wiley   +1 more source

Insect pests in Brassica napus crops: toward ecologically optimized integrated pest management

Pest Management Science, EarlyView.
Ecologically optimized IPM: Integrating landscape, biological, and chemical strategies for enhanced pest management. Key findings: Optimizing canola IPM requires the deliberate alignment of habitat diversification, behavioral conditioning, and evolutionary processes.
Jhon Alexander Avellaneda Nieto, Wei Xu, Shovon Chandra Sarkar   +2 more
wiley   +1 more source

Immunomodulatory Properties of Withania somnifera: Regulation of Innate Immune Cells and Clinical Implications

Phytotherapy Research, EarlyView.
ABSTRACT Withania somnifera (L.) Dunal (WS), commonly known as Ashwagandha, is a prominent medicinal herb in Ayurveda, with extensive therapeutic potential attributed to its diverse phytochemical profile. This review critically examines the immunomodulatory properties of WS, focusing on innate immune cell populations, including neutrophils, eosinophils,
Rana Yukta, Sonalika Gupta, Gagandeep Kaur, Partha Sarathi Mondal, Milirani Das, Anagha Ranade, Alok Kumar Srivastava, Sachin Kumar, Manoj Kumar Barthwal, Madhu Dikshit   +9 more
wiley   +1 more source