Results 171 to 180 of about 192,930 (304)

Nanopore Electroporation: A New Delivery Method Within the Field of Epigenetic Editing

Small, EarlyView.
Nanopore‐mediated electroporation was used to deliver a CRISPRi system to clonal β‐cells. This enabled targeted downregulation of insulin expression while maintaining high cell viability. ABSTRACT Epigenetic modifications influence gene expression and contribute to type 2 diabetes (T2D), but establishing causality requires targeted modulation of ...
Frida Ekstrand, Sabrina Ruhrmann, Karl Bacos, Sabine Bartel, Pytrick Jellema, Marianne G. Rots, Charlotte Ling, Christelle N. Prinz   +7 more
wiley   +1 more source

Donor-Derived Cell-Free DNA (dd-cfDNA) as an Early Noninvasive Biomarker of Graft Injury in Pig-to-Monkey Islet Xenotransplantation. [PDF]

Xenotransplantation
Yan JJ, Kim JM, Cho SI, Kim H, Kwak K, Kim H, Oh EJ, Yang J, Park CG, Jeong JC, Kim BS.   +10 more
europepmc   +1 more source

The clashing of in situ and pre‐cast technologies—Western trends and local traditions in concrete engineering shaping shell construction in 20th‐century Hungary

Structural Concrete, EarlyView.
Abstract After a blossoming pre‐World War II (WWII) period, the concrete construction industry in then‐socialist Hungary existed in a relative isolation from the Western World during the mid‐20th century. In this paper, we focus on the body of work of one of the then newly established state‐owned design offices, IPARTERV, to show how the isolation ...
Orsolya Gáspár, Péter Haba
wiley   +1 more source

Activation of the Pancreatic "Metabolic Synapse" Aggravates Type 2 Diabetes Mellitus by Inducing PANoptosis in β-Cells. [PDF]

Diabetes
Xiang Z, Zitian L, Guangwei Y, Shuohui D, Kexin W.   +4 more
europepmc   +1 more source

Land and Water Pedagogy in TESOL: Centering Indigenous Knowledges

TESOL Quarterly, EarlyView.
Abstract The intersection of English Language Teaching (ELT), TESOL, and Indigenous knowledges is an important yet often neglected area of inquiry. This paper explores the importance of including Indigenous knowledges – specifically land and water pedagogies – in ELT, TESOL, and broader language education practices. Through duoethnographic inquiry, we –
Paul J. Meighan, Madoka Hammine
wiley   +1 more source

Reuniting diabetes through the islet coordinate framework. [PDF]

Lancet Diabetes Endocrinol
Jagannathan R, Staimez LR, Narayan KMV.
europepmc   +1 more source

Contrasting the synoptic drivers of the UK heatwaves of 1976, 2003, 2018 and 2022

Weather, EarlyView.
UK summer heatwaves are dictated by the polar jet stream position and sea surface temperature (SST) variability, affecting the Summer North Atlantic Oscillation (SNAO) index. The SNAO can determine and influence the Central England Precipitation (CEP) and Central England Temperature (CET).
Nedim Sladić, Richard P. Allan, Tim Trent, Adam C. Povey, Dan Suri   +4 more
wiley   +1 more source

Fatal lightning strikes in Ireland from newspaper records 1900–2024

Weather, EarlyView.
This study presents a chronology of fatal lightning strikes in Ireland (1900–2024) derived from digitised newspaper archives. Analysis provides insights into the seasonality, location, victim activity and synoptic conditions (from Lamb weather types) of 94 fatal events causing 113 deaths.
Rory Moore, Conor Murphy, Rowan Fealy
wiley   +1 more source

Mechanisms inducing differentiation of adult islet progenitor-like cells into functional islet-like organoids. [PDF]

Front Transplant
Darden CM, Kuncha J, Kirkland JT, Mattke J, Vasu S, Saravanan PB, Naziruddin B, Lawrence MC.   +7 more
europepmc   +1 more source

An international consensus on screening and monitoring early-stage type 1 diabetes: A roadmap to European implementation. [PDF]

Diabetes Obes Metab
Hussain S, Tree T, Mathieu C, Klupa T, Tuomaala AK, de Wit M, Kordonouri O, Braune K, Pall J, Castano L, Besser REJ, Galhardo J, Ulivi F, Bosi E, Bogdanovic U, Alabert C, Battelino T.   +16 more
europepmc   +1 more source