Results 11 to 20 of about 235,553 (209)
Abnormal infant islet morphology precedes insulin resistance in PCOS-like monkeys. [PDF]
, 2014 Polycystic ovary syndrome (PCOS) is prevalent in reproductive-aged women and confounded by metabolic morbidities, including insulin resistance and type 2 diabetes.
Abbott, David H +5 more
core +12 more sources
Islet isolation assessment in man and large animals [PDF]
, 1990 Recent progress in islet isolation from the pancreas of large mammals including man, accentuated the need for the development of precise and reproducible techniques to assess islet yield.
Alejandro, R +25 more
core +1 more source
Human monoclonal islet specific autoantibodies share features of islet cell and 64 kDa antibodies [PDF]
, 1993 The first human monoclonal islet cell antibodies of the IgG class (MICA 1-6) obtained from an individual with Type 1 (insulin-dependent) diabetes mellitus were cytoplasmic islet cell antibodies selected by the indirect immunofluorescence test on pancreas
DJ Garry +19 more
core +1 more source
A role for the extracellular calcium-sensing receptor in cell-cell communication in pancreatic islets of langerhans [PDF]
, 2008 Background: The extracellular calcium-sensing receptor (CaR) is expressed in many tissues that are not associated with Ca2+ homeostasis, including the endocrine cells in pancreatic islets of Langerhans.
Burns, Christopher +4 more
core +1 more source
Outcomes of Islet Autotransplantation in Chronic Pancreatitis Patients with Complete Acinar Atrophy
Cell Transplantation, 2020 Total pancreatectomy with islet autotransplantation (TPIAT) is a promising treatment for refractory chronic pancreatitis (CP). Pathological features of CP include progressive fibrosis in pancreas parenchyma, atrophy, and/or ductal occlusion.
Gumpei Yoshimatsu MD, PhD +8 more
doaj +1 more source
Cyclic AMP signalling in pancreatic islets [PDF]
, 2010 Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in ...
Furman, Brian +2 more
core +1 more source
Frontiers in Genetics, 2022 The dysfunction of islet β-cells is one of the causes of diabetes, and lncRNA Gm10451 is also a participant in the occurrence and the development of various diseases. This study was carried out to reveal the correlation within β-cells and Gm10451.
Jiao Wang +6 more
doaj +1 more source
Profiling of RNAs from Human Islet-Derived Exosomes in a Model of Type 1 Diabetes [PDF]
, 2019 Type 1 diabetes (T1D) is characterized by the immune-mediated destruction of insulin-producing islet β cells. Biomarkers capable of identifying T1D risk and dissecting disease-related heterogeneity represent an unmet clinical need.
Evans-Molina, Carmella +4 more
core +1 more source
A Versatile, Portable Intravital Microscopy Platform for Studying Beta-cell Biology In Vivo [PDF]
, 2019 The pancreatic islet is a complex micro-organ containing numerous cell types, including endocrine, immune, and endothelial cells. The communication of these systems is lost upon isolation of the islets, and therefore the pathogenesis of diabetes can only
Conteh, Abass M. +11 more
core +1 more source
Cells, 2021 The nutrient-sensor O-GlcNAc transferase (Ogt), the sole enzyme that adds an O-GlcNAc-modification onto proteins, plays a critical role for pancreatic β-cell survival and insulin secretion.
Ramkumar Mohan +8 more
doaj +1 more source