Results 11 to 20 of about 126,560 (317)

Short-chain fatty acid concentrations in the incidence and risk-stratification of colorectal cancer: a systematic review and meta-analysis

BMC Medicine, 2022
Background The beneficial role of gut microbiota and bacterial metabolites, including short-chain fatty acids (SCFAs), is well recognized, although the available literature around their role in colorectal cancer (CRC) has been inconsistent.
Ehsan Alvandi, Wilson K. M. Wong, Mugdha V. Joglekar, Kevin J. Spring, Anandwardhan A. Hardikar   +4 more
doaj   +1 more source

Mitochondrial regulation in human pluripotent stem cells during reprogramming and β cell differentiation

Frontiers in Endocrinology, 2023
Mitochondria are the powerhouse of the cell and dynamically control fundamental biological processes including cell reprogramming, pluripotency, and lineage specification.
Ila Tewari Jasra, Nerea Cuesta-Gomez, Kevin Verhoeff, Braulio A. Marfil-Garza, Braulio A. Marfil-Garza, Nidheesh Dadheech, A. M. James Shapiro   +6 more
doaj   +1 more source

Islet Culture/Preservation before Islet Transplantation [PDF]

Cell Medicine, 2015
Although islet culture prior to transplantation provides flexibility for the evaluation of isolated islets and the pretreatment of patients, it is well known that isolated islets deteriorate rapidly in culture. Human serum albumin (HSA) is used for medium supplementation instead of fetal bovine serum (FBS), which is typically used for islet culture ...
Hirofumi, Noguchi, Chika, Miyagi-Shiohira, Kiyoto, Kurima, Naoya, Kobayashi, Issei, Saitoh, Masami, Watanabe, Yasufumi, Noguchi, Masayuki, Matsushita   +7 more
openaire   +2 more sources

Pancreas and islet morphology in cystic fibrosis: clues to the etiology of cystic fibrosis-related diabetes

Frontiers in Endocrinology, 2023
Cystic fibrosis (CF) is a multi-organ disease caused by loss-of-function mutations in CFTR (which encodes the CF transmembrane conductance regulator ion channel).
Sarah S. Malik, Sarah S. Malik, Diksha Padmanabhan, Diksha Padmanabhan, Rebecca L. Hull-Meichle, Rebecca L. Hull-Meichle, Rebecca L. Hull-Meichle, Rebecca L. Hull-Meichle   +7 more
doaj   +1 more source

Fresh Islets are more Effective for Islet Transplantation than Cultured Islets [PDF]

Cell Transplantation, 2012
For clinical islet transplantation, isolated islets deteriorate rapidly in culture, although culturing islets prior to transplantation provides flexibility for evaluation of isolated islets and pretreatment of patients. In the present study, we compared human fresh islets to cultured islets with in vitro and in vivo assays.
Hirofumi Noguchi M.D., Ph.D., Bashoo Naziruddin, Andrew Jackson, Masayuki Shimoda, Tetsuya Ikemoto, Yasutaka Fujita, Daisuke Chujo, Morihito Takita, Han Peng, Koji Sugimoto, Takeshi Itoh, Naoya Kobayashi, Nicholas Onaca, Marlon F. Levy, Shinichi Matsumoto   +14 more
openaire   +3 more sources

Targeting pancreatic islet NLRP3 improves islet graft revascularization

Diabetes, 2022
<p>  </p> <p>Hypoxia-induced islet cell death, caused by an insufficient revascularization of the grafts, is a major obstacle for successful pancreatic islet transplantation. Recently, it has been reported that the nucleotide-binding oligomerization domain (NOD)-like receptor protein (NLRP)3 inflammasome is expressed in pancreatic ...
Selina Wrublewsky, Thimoteus Speer, Lisa Nalbach, Anne S. Boewe, Mandy Pack, Dalia Alansary, Leticia P. Roma, Markus D.A. Hoffmann, Beate M. Schmitt, Andrea Weinzierl, Michael D. Menger, Matthias W. Laschke, Emmanuel Ampofo   +12 more
openaire   +2 more sources

Intramuscular islet transplantation promotes restored islet vascularity [PDF]

Islets, 2011
In a recent publication, we reported that islets transplanted to mouse striated muscle became revascularized with intra-islet vessel densities comparable to native islets. Revascularization of islet grafts was completely dependent on recruited Gr-1+ leukocytes.
Christoffersson G, Carlsson PO, Phillipson M   +2 more
openaire   +3 more sources

Islet Transplantation in the UK [PDF]

CellR4, 2019
This commentary outlines the development and current status of the UK Islet Transplant Programme in the UK. The author makes the case that it is now time for similar fully funded beta-cell programmes to be made available in many other countries as well.
P. Johnson, On behalf of the UK Islet Transplant Consortium (UKITC)   +1 more
doaj   +1 more source

In depth functional characterization of human induced pluripotent stem cell-derived beta cells in vitro and in vivo

Frontiers in Cell and Developmental Biology, 2022
In vitro differentiation of human induced pluripotent stem cells (iPSCs) into beta cells represents an important cell source for diabetes research. Here, we fully characterized iPSC-derived beta cell function in vitro and in vivo in humanized mice. Using
Federica Fantuzzi, Federica Fantuzzi, Sanna Toivonen, Andrea Alex Schiavo, Heeyoung Chae, Mohammad Tariq, Toshiaki Sawatani, Nathalie Pachera, Ying Cai, Chiara Vinci, Enrico Virgilio, Laurence Ladriere, Mara Suleiman, Piero Marchetti, Jean-Christophe Jonas, Patrick Gilon, Décio L. Eizirik, Mariana Igoillo-Esteve, Miriam Cnop, Miriam Cnop   +19 more
doaj   +1 more source

The ischaemic preconditioning paradox and its implications for islet isolation from heart-beating and non heart-beating donors

Scientific Reports, 2022
The impact of ischaemia can severely damage procured donor organs for transplantation. The pancreas, and pancreatic islets in particular, is one of the most sensitive tissues towards hypoxia.
Daniel Brandhorst, Heide Brandhorst, Samuel Acreman, Paul R. V. Johnson   +3 more
doaj   +1 more source