Results 201 to 210 of about 47,870 (244)

Cyclosporine and Islet Mass—Implications for Islet Transplantation

Journal of Surgical Research, 1993
Cyclosporine (CsA) is an inhibitor of ornithine decarboxylase (ODC), a key enzymatic step in cell proliferation. The purpose of this study was to determine the effect of CsA on islet cell mass. Partial obstruction (PDO) of the hamster pancreas is an established model of islet cell differentiation and proliferation in which regeneration is mediated by ...
P, Metrakos, L, Hornby, L, Rosenberg
openaire   +2 more sources

Superiority of Fresh Islets Compared With Cultured Islets

Transplantation Proceedings, 2009
It has recently been reported that the outcomes of islet transplantation with short periods of culture are comparable with those of freshly isolated islets. To clarify the influence of culture, fresh islets were compared with cultured islets in terms of quality.The quality of freshly isolated islets was compared with that of cultured islets with CMRL ...
H, Takahashi, M, Goto, N, Ogawa, Y, Saito, K, Fujimori, Y, Kurokawa, H, Doi, S, Satomi   +7 more
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Influence of the Numbers of Islets on the Models of Rat Syngeneic-Islet and Allogeneic-Islet Transplantations

Transplantation Proceedings, 2006
One of the main barriers to widespread application of islet transplantation is the limited availability of human pancreatic islets. The reduction of graft islet mass for transplantation to a recipient is one of the strategies in islet transplantation. However, transplantation of only a small number of islets may result in primary nonfunction.
Y, Hara, M, Fujino, K, Nakada, K, Kimura, K, Adachi, X-K, Li   +5 more
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Regulation of Islet Amyloid Polypeptide in Human Pancreatic Islets

Diabetes, 1993
This study investigated the effect of glucose on islet amyloid polypeptide secretion, content, and mRNA synthesis of human pancreatic islets. The release of islet amyloid polypeptide from fresh isolated islets in response to glucose was parallel to that of insulin.
A, Novials, Y, Sarri, R, Casamitjana, F, Rivera, R, Gomis   +4 more
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Islet Cell Transplantation

Current Molecular Medicine, 2006
Islet cell transplantation is an attractive alternative therapy to conventional insulin treatment or vascularized whole pancreas transplantation for type 1 diabetic patients. It represents a successful example of somatic cell therapy in humans based on complex procedures for islet isolation from whole pancreas. The islets, that are only 1% of the total
Bertuzzi F, MArzorati S, SECCHI , ANTONIO   +2 more
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Porcine Islets as an Alternative to Human Islets for Transplantation

Journal of Investigative Medicine, 2001
My discussion will focus on the use of porcine islets as an alternative to human islets for transplantation. In my opinion, allotransplantation (human-to-human) will remain the gold standard. I hope to convince you by the end of this talk, however, that in the future, there may be a need to consider alternative sources of organs.
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Islet Transplantation: Factors in Short-Term Islet Survival

Archivum Immunologiae et Therapiae Experimentalis, 2011
Islet transplantation has the potential to cure type 1 diabetes. In recent years, the proportion of patients achieving initial insulin independence has improved, but longer term outcomes remain poor compared to those for whole pancreas transplants.
Natasha A, Deters, Rebecca A, Stokes, Jenny E, Gunton   +2 more
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Islet Function in Diabetics with Persistent Islet Cell Antibodies

Diabetes, 1978
Seventeen (14 per cent) of 121 long-term insulin-treated diabetics were found to be positive for islet cell antibodies. Their duration of diabetes ranged between five and 45 years. Thirteen of these 17 patients were tested for the persistence of islet cell function by measurement of C-peptide.
C G, Theophanides, D A, Pyke, P J, Watkins   +2 more
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Islet Macroencapsulation: Strategies to Boost Islet Graft Oxygenation

2023
Islet transplantation is a valid therapy for patients with type 1 diabetes. However, a widespread application is hampered by mandatory requirement of life-long immunosuppression, the shortage of cadaveric donor organs, and the limited long-term efficacy.
Ludwig, B., Heller, C., Sarangova, V., Welzel, P.B.   +3 more
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Rapamycin Induces Autophagy in Islets: Relevance in Islet Transplantation

Transplantation Proceedings, 2009
Islet transplantation can provide insulin independence in patients with type 1 diabetes mellitus. However, islet allograft recipients exhibit a gradual decline in insulin independence, and only 10% do not require insulin at 5 years. This decline may reflect drug toxicity to islet beta cells.
M, Tanemura, A, Saga, K, Kawamoto, T, Machida, T, Deguchi, T, Nishida, Y, Sawa, Y, Doki, M, Mori, T, Ito   +9 more
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